ARHGEF25 — 83 ClinVar variants

All ClinVar germline ARHGEF25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →

1 Likely pathogenic · 1 Benign · 1 Likely benign · 80 Uncertain significance

Full ARHGEF25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 62

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

ARHGEF25 p.Arg443Cys Likely pathogenic No assertion criteria
Moyamoya angiopathy

Predictors lean, ClinVar uncertain 50

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All ARHGEF25 variants

Likely pathogenic 1

p.Arg443Cys No assertion criteria Moyamoya angiopathy ⚠

Benign 1

p.Gln506= Single submitter

Likely benign 1

p.Glu129= Single submitter

Uncertain significance 80

p.Ala192Val Single submitter ⚠
p.Ala25Pro Single submitter
p.Ala462Val Single submitter ⚠
p.Ala68Ser Single submitter
p.Ala68Val Single submitter
p.Arg14Leu Single submitter
p.Arg14Trp Single submitter
p.Arg294Gln Single submitter ⚠
p.Arg332His Single submitter ⚠
p.Arg375Gln Single submitter ⚠
p.Arg377Gln Single submitter ⚠
p.Arg377Leu Single submitter ⚠
p.Arg399Ile Single submitter ⚠
p.Arg429His Single submitter ⚠
p.Arg443His Single submitter ⚠
p.Arg443Leu Single submitter ⚠
p.Arg469Trp Single submitter
p.Arg484Gln Single submitter ⚠
p.Arg484Trp Single submitter ⚠
p.Arg493Trp Single submitter ⚠
p.Asp219Asn Single submitter ⚠
p.Cys253Arg Single submitter ⚠
p.Cys88Tyr Single submitter ⚠
p.Gln136Lys Single submitter ⚠
p.Gln181Lys Single submitter ⚠
p.Gln352Leu Single submitter ⚠
p.Gln424Glu Single submitter ⚠
p.Gln476Arg Single submitter ⚠
p.Glu116Lys Single submitter ⚠
p.Glu224Gly Single submitter
p.Glu273Asp Single submitter ⚠
p.Glu32Asp Single submitter
p.Glu385Asp Single submitter ⚠
p.Glu46Lys Single submitter
p.Gly21Cys Single submitter
p.Gly21Val Single submitter
p.Gly279Arg Single submitter
p.Gly33Glu Single submitter
p.Gly405Val Single submitter ⚠
p.Gly418Ala Single submitter ⚠
p.Gly439Val Single submitter ⚠
p.Gly51Cys Single submitter ⚠
p.Gly51Ser Single submitter ⚠
p.Gly73Glu Single submitter ⚠
p.His516Pro Single submitter ⚠
p.Ile15Met Single submitter
p.Ile458Phe Single submitter ⚠
p.Ile519Val Single submitter ⚠
p.Leu128Ser Single submitter ⚠
p.Leu28Pro Single submitter
p.Leu302Ile Single submitter ⚠
p.Leu423Ile Single submitter ⚠
p.Leu82Ser Single submitter ⚠
p.Lys459Arg Single submitter ⚠
p.Met19Thr Single submitter
p.Met22Ile Single submitter
p.Met336Ile Single submitter ⚠
p.Phe271Ser Single submitter ⚠
p.Phe328Leu Single submitter ⚠
p.Pro102Ser Single submitter ⚠
p.Pro257Ser Single submitter ⚠
p.Pro291His Single submitter ⚠
p.Pro3Thr Single submitter
p.Pro404Ser Single submitter ⚠
p.Pro427Thr Single submitter ⚠
p.Pro518Arg Single submitter ⚠
p.Pro66Ala Single submitter ⚠
p.Pro72Gln Single submitter ⚠
p.Ser166Asn Single submitter ⚠
p.Ser198Arg Single submitter ⚠
p.Ser522Phe Single submitter ⚠
p.Ser560Tyr Single submitter ⚠
p.Ser64Cys Single submitter ⚠
p.Thr135Met Single submitter ⚠
p.Thr338Met Single submitter ⚠
p.Tyr35Cys Single submitter ⚠
p.Val263Leu Single submitter ⚠
p.Val381Ile Single submitter ⚠
p.Val91Ala Single submitter ⚠
c.657-7C>A No assertion criteria prostate cancer