ARHGEF3 — 67 ClinVar variants
All ClinVar germline ARHGEF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
3 Likely benign · 64 Uncertain significance
Full ARHGEF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF3 p.Ala403Pro Uncertain significance Single submitter
- ARHGEF3 p.Ala92Thr Uncertain significance Single submitter
- ARHGEF3 p.Arg185Gln Uncertain significance Single submitter
- ARHGEF3 p.Arg311Leu Uncertain significance Single submitter
- ARHGEF3 p.Arg316Trp Uncertain significance Single submitter
- ARHGEF3 p.Arg445Cys Uncertain significance Single submitter
- ARHGEF3 p.Arg445His Uncertain significance Single submitter
- ARHGEF3 p.Arg475Gly Uncertain significance Single submitter
- ARHGEF3 p.Asn344Ser Uncertain significance Single submitter
- ARHGEF3 p.Asn518Lys Uncertain significance Single submitter
- ARHGEF3 p.Asn525Lys Uncertain significance Single submitter
- ARHGEF3 p.Asp191His Uncertain significance Single submitter
- ARHGEF3 p.Asp487Glu Uncertain significance Single submitter
- ARHGEF3 p.Asp494His Uncertain significance Single submitter
- ARHGEF3 p.Cys111Ser Uncertain significance Single submitter
- ARHGEF3 p.Cys336Phe Uncertain significance Single submitter
- ARHGEF3 p.Gln355Arg Uncertain significance Single submitter
- ARHGEF3 p.Glu106Val Uncertain significance Single submitter
- ARHGEF3 p.Glu243Lys Uncertain significance Single submitter
- ARHGEF3 p.Glu464Lys Uncertain significance Single submitter
- ARHGEF3 p.Glu464Val Uncertain significance Single submitter
- ARHGEF3 p.Gly296Glu Uncertain significance Single submitter
- ARHGEF3 p.Gly323Ser Uncertain significance Single submitter
- ARHGEF3 p.Gly456Arg Uncertain significance Single submitter
- ARHGEF3 p.Gly473Arg Uncertain significance Single submitter
- ARHGEF3 p.His338Asp Uncertain significance Single submitter
- ARHGEF3 p.Leu163Phe Uncertain significance Single submitter
- ARHGEF3 p.Leu242Ser Uncertain significance Single submitter
- ARHGEF3 p.Leu274Val Uncertain significance Single submitter
- ARHGEF3 p.Leu370Pro Uncertain significance Single submitter
- ARHGEF3 p.Leu385Met Uncertain significance Single submitter
- ARHGEF3 p.Leu385Val Uncertain significance Single submitter
- ARHGEF3 p.Leu468Val Uncertain significance Single submitter
- ARHGEF3 p.Lys314Arg Uncertain significance Single submitter
- ARHGEF3 p.Met497Leu Uncertain significance Single submitter
- ARHGEF3 p.Met509Val Uncertain significance Single submitter
- ARHGEF3 p.Pro199Arg Uncertain significance Single submitter
- ARHGEF3 p.Pro41Ser Uncertain significance Single submitter
- ARHGEF3 p.Pro86Ser Uncertain significance Single submitter
- ARHGEF3 p.Ser118Ala Uncertain significance Single submitter
- ARHGEF3 p.Ser193Leu Uncertain significance Single submitter
- ARHGEF3 p.Ser428Leu Uncertain significance Single submitter
- ARHGEF3 p.Ser489Pro Uncertain significance Single submitter
- ARHGEF3 p.Thr66Asn Uncertain significance Single submitter
- ARHGEF3 p.Thr96Ala Uncertain significance Single submitter
- ARHGEF3 p.Trp87Arg Uncertain significance Single submitter
- ARHGEF3 p.Val112Ile Uncertain significance Single submitter
- ARHGEF3 p.Val347Met Uncertain significance Single submitter
- ARHGEF3 p.Val39Ala Uncertain significance Single submitter
- ARHGEF3 p.Val526Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ARHGEF3 p.Ala403Thr Uncertain significance Single submitter
- ARHGEF3 p.Arg376Cys Uncertain significance Single submitter
- ARHGEF3 p.Arg401Gln Uncertain significance Single submitter
- ARHGEF3 p.Asn217Lys Uncertain significance Single submitter
- ARHGEF3 p.Asn343Asp Uncertain significance Single submitter
- ARHGEF3 p.Gln425Glu Uncertain significance Single submitter
- ARHGEF3 p.Glu408Gly Uncertain significance Single submitter
- ARHGEF3 p.Gly397Arg Uncertain significance Single submitter
- ARHGEF3 p.Leu396Gln Uncertain significance Single submitter
- ARHGEF3 p.Phe435Leu Uncertain significance Single submitter
- ARHGEF3 p.Ser496Arg Uncertain significance Single submitter
All ARHGEF3 variants
Likely benign 3
- p.Thr471Ala Single submitter
- p.Thr66= Single submitter
- p.Val364Ile Single submitter
Uncertain significance 64
- p.Ala403Pro Single submitter ⚠
- p.Ala403Thr Single submitter ⚠
- p.Ala92Thr Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg24Trp Single submitter
- p.Arg311Leu Single submitter ⚠
- p.Arg316Trp Single submitter ⚠
- p.Arg376Cys Single submitter ⚠
- p.Arg401Gln Single submitter ⚠
- p.Arg445Cys Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg475Gly Single submitter ⚠
- p.Asn217Lys Single submitter ⚠
- p.Asn343Asp Single submitter ⚠
- p.Asn344Ser Single submitter ⚠
- p.Asn518Lys Single submitter ⚠
- p.Asn525Lys Single submitter ⚠
- p.Asp191His Single submitter ⚠
- p.Asp487Glu Single submitter ⚠
- p.Asp494His Single submitter ⚠
- p.Cys111Ser Single submitter ⚠
- p.Cys336Phe Single submitter ⚠
- p.Gln324Leu Single submitter
- p.Gln355Arg Single submitter ⚠
- p.Gln425Glu Single submitter ⚠
- p.Glu106Val Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu408Gly Single submitter ⚠
- p.Glu464Lys Single submitter ⚠
- p.Glu464Val Single submitter ⚠
- p.Gly296Glu Single submitter ⚠
- p.Gly323Ser Single submitter ⚠
- p.Gly397Arg Single submitter ⚠
- p.Gly456Arg Single submitter ⚠
- p.Gly473Arg Single submitter ⚠
- p.His338Asp Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Leu242Ser Single submitter ⚠
- p.Leu274Val Single submitter ⚠
- p.Leu370Pro Single submitter ⚠
- p.Leu385Met Single submitter ⚠
- p.Leu385Val Single submitter ⚠
- p.Leu396Gln Single submitter ⚠
- p.Leu468Val Single submitter ⚠
- p.Lys314Arg Single submitter ⚠
- p.Met497Leu Single submitter ⚠
- p.Met509Val Single submitter ⚠
- p.Phe435Leu Single submitter ⚠
- p.Pro199Arg Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser118Ala Single submitter ⚠
- p.Ser193Leu Single submitter ⚠
- p.Ser428Leu Single submitter ⚠
- p.Ser489Pro Single submitter ⚠
- p.Ser496Arg Single submitter ⚠
- p.Thr66Asn Single submitter ⚠
- p.Thr96Ala Single submitter ⚠
- p.Trp87Arg Single submitter ⚠
- p.Tyr319His Single submitter
- p.Val112Ile Single submitter ⚠
- p.Val347Met Single submitter ⚠
- p.Val39Ala Single submitter ⚠
- p.Val526Ile Single submitter ⚠