ARHGEF35 — 81 ClinVar variants
All ClinVar germline ARHGEF35 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
13 Likely benign · 68 Uncertain significance
Full ARHGEF35 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF35 p.Ala126Thr Uncertain significance Single submitter
- ARHGEF35 p.Ala199Thr Uncertain significance Single submitter
- ARHGEF35 p.Ala447Thr Uncertain significance Single submitter
- ARHGEF35 p.Ala448Thr Uncertain significance Single submitter
- ARHGEF35 p.Arg286Thr Uncertain significance Single submitter
- ARHGEF35 p.Arg290Thr Uncertain significance Single submitter
- ARHGEF35 p.Arg328Met Uncertain significance Single submitter
- ARHGEF35 p.Arg392Ser Uncertain significance Single submitter
- ARHGEF35 p.Arg440Thr Uncertain significance Single submitter
- ARHGEF35 p.Asp142Asn Uncertain significance Single submitter
- ARHGEF35 p.Asp66Asn Uncertain significance Single submitter
- ARHGEF35 p.Gln130Glu Uncertain significance Single submitter
- ARHGEF35 p.Gln219Glu Uncertain significance Single submitter
- ARHGEF35 p.Glu187Gln Uncertain significance Single submitter
- ARHGEF35 p.Glu187Lys Uncertain significance Single submitter
- ARHGEF35 p.Glu298Val Uncertain significance Single submitter
- ARHGEF35 p.Glu329Asp Uncertain significance Single submitter
- ARHGEF35 p.Glu343Lys Uncertain significance Single submitter
- ARHGEF35 p.Glu378Gly Uncertain significance Single submitter
- ARHGEF35 p.Glu380Asp Uncertain significance Single submitter
- ARHGEF35 p.Gly164Arg Uncertain significance Single submitter
- ARHGEF35 p.Gly178Val Uncertain significance Single submitter
- ARHGEF35 p.Gly198Ser Uncertain significance Single submitter
- ARHGEF35 p.Gly207Arg Uncertain significance Single submitter
- ARHGEF35 p.Gly244Glu Uncertain significance Single submitter
- ARHGEF35 p.Gly288Ala Uncertain significance Single submitter
- ARHGEF35 p.Gly316Arg Uncertain significance Single submitter
- ARHGEF35 p.Gly467Asp Uncertain significance Single submitter
- ARHGEF35 p.His223Asn Uncertain significance Single submitter
- ARHGEF35 p.Ile262Val Uncertain significance Single submitter
- ARHGEF35 p.Ile364Met Uncertain significance Single submitter
- ARHGEF35 p.Ile411Thr Uncertain significance Single submitter
- ARHGEF35 p.Leu452Val Uncertain significance Single submitter
- ARHGEF35 p.Lys273Glu Uncertain significance Single submitter
- ARHGEF35 p.Lys327Thr Uncertain significance Single submitter
- ARHGEF35 p.Lys377Gln Uncertain significance Single submitter
- ARHGEF35 p.Met136Leu Uncertain significance Single submitter
- ARHGEF35 p.Met407Val Uncertain significance Single submitter
- ARHGEF35 p.Pro154Ser Uncertain significance Single submitter
- ARHGEF35 p.Pro408Ser Uncertain significance Single submitter
- ARHGEF35 p.Pro46Thr Uncertain significance Single submitter
- ARHGEF35 p.Pro76Leu Uncertain significance Single submitter
- ARHGEF35 p.Ser372Thr Uncertain significance Single submitter
- ARHGEF35 p.Ser381Ile Uncertain significance Single submitter
- ARHGEF35 p.Ser395Gly Uncertain significance Single submitter
- ARHGEF35 p.Ser416Ala Uncertain significance Single submitter
- ARHGEF35 p.Thr100Pro Uncertain significance Single submitter
- ARHGEF35 p.Thr172Asn Uncertain significance Single submitter
- ARHGEF35 p.Thr172Pro Uncertain significance Single submitter
- ARHGEF35 p.Thr245Ala Uncertain significance Single submitter
- ARHGEF35 p.Thr294Ser Uncertain significance Single submitter
- ARHGEF35 p.Thr437Ala Uncertain significance Single submitter
- ARHGEF35 p.Thr74Met Uncertain significance Single submitter
- ARHGEF35 p.Trp125Arg Uncertain significance Single submitter
- ARHGEF35 p.Val86Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- ARHGEF35 p.Asp253Tyr Uncertain significance Single submitter
- ARHGEF35 p.Glu148Lys Uncertain significance Single submitter
- ARHGEF35 p.Glu271Gln Uncertain significance Single submitter
- ARHGEF35 p.Glu324Lys Uncertain significance Single submitter
- ARHGEF35 p.Glu397Gln Uncertain significance Single submitter
- ARHGEF35 p.Glu399Lys Uncertain significance Single submitter
- ARHGEF35 p.Gly295Trp Uncertain significance Single submitter
- ARHGEF35 p.Leu444Met Uncertain significance Single submitter
- ARHGEF35 p.Leu452Phe Uncertain significance Single submitter
- ARHGEF35 p.Phe152Leu Likely benign Single submitter
- ARHGEF35 p.Ser30Asn Uncertain significance Single submitter
- ARHGEF35 p.Trp382Cys Uncertain significance Single submitter
- ARHGEF35 p.Val279Ile Uncertain significance Single submitter
- ARHGEF35 p.Val429Met Uncertain significance Single submitter
All ARHGEF35 variants
Likely benign 13
- p.Ala393Val Single submitter
- p.Arg114Gln Single submitter
- p.Arg241Gln Single submitter
- p.Arg457= Single submitter
- p.Gln219Arg Single submitter
- p.Gly292Arg Single submitter
- p.Leu421Val Single submitter
- p.Leu428= Single submitter
- p.Phe152Leu Single submitter ⚠
- p.Pro185Ser Single submitter
- p.Ser184Pro Single submitter
- p.Thr347Ser Single submitter
- p.Val227Ala Single submitter
Uncertain significance 68
- p.Ala126Thr Single submitter ⚠
- p.Ala199Thr Single submitter ⚠
- p.Ala447Thr Single submitter ⚠
- p.Ala448Thr Single submitter ⚠
- p.Arg286Thr Single submitter ⚠
- p.Arg290Thr Single submitter ⚠
- p.Arg328Met Single submitter ⚠
- p.Arg392Ser Single submitter ⚠
- p.Arg440Thr Single submitter ⚠
- p.Asp142Asn Single submitter ⚠
- p.Asp253Tyr Single submitter ⚠
- p.Asp66Asn Single submitter ⚠
- p.Gln130Glu Single submitter ⚠
- p.Gln219Glu Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Glu187Gln Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu271Gln Single submitter ⚠
- p.Glu298Val Single submitter ⚠
- p.Glu324Lys Single submitter ⚠
- p.Glu329Asp Single submitter ⚠
- p.Glu343Lys Single submitter ⚠
- p.Glu378Gly Single submitter ⚠
- p.Glu380Asp Single submitter ⚠
- p.Glu397Gln Single submitter ⚠
- p.Glu399Lys Single submitter ⚠
- p.Gly164Arg Single submitter ⚠
- p.Gly178Val Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Gly207Arg Single submitter ⚠
- p.Gly244Glu Single submitter ⚠
- p.Gly288Ala Single submitter ⚠
- p.Gly295Trp Single submitter ⚠
- p.Gly316Arg Single submitter ⚠
- p.Gly467Asp Single submitter ⚠
- p.His223Asn Single submitter ⚠
- p.Ile262Val Single submitter ⚠
- p.Ile364Met Single submitter ⚠
- p.Ile411Thr Single submitter ⚠
- p.Leu444Met Single submitter ⚠
- p.Leu452Phe Single submitter ⚠
- p.Leu452Val Single submitter ⚠
- p.Lys273Glu Single submitter ⚠
- p.Lys327Thr Single submitter ⚠
- p.Lys377Gln Single submitter ⚠
- p.Met136Leu Single submitter ⚠
- p.Met407Val Single submitter ⚠
- p.Pro154Ser Single submitter ⚠
- p.Pro408Ser Single submitter ⚠
- p.Pro46Thr Single submitter ⚠
- p.Pro76Leu Single submitter ⚠
- p.Ser30Asn Single submitter ⚠
- p.Ser372Thr Single submitter ⚠
- p.Ser381Ile Single submitter ⚠
- p.Ser395Gly Single submitter ⚠
- p.Ser416Ala Single submitter ⚠
- p.Thr100Pro Single submitter ⚠
- p.Thr172Asn Single submitter ⚠
- p.Thr172Pro Single submitter ⚠
- p.Thr245Ala Single submitter ⚠
- p.Thr294Ser Single submitter ⚠
- p.Thr437Ala Single submitter ⚠
- p.Thr74Met Single submitter ⚠
- p.Trp125Arg Single submitter ⚠
- p.Trp382Cys Single submitter ⚠
- p.Val279Ile Single submitter ⚠
- p.Val429Met Single submitter ⚠
- p.Val86Met Single submitter ⚠