ARHGEF37 — 109 ClinVar variants
All ClinVar germline ARHGEF37 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
7 Likely benign · 102 Uncertain significance
Full ARHGEF37 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 82
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF37 p.Ala353Thr Uncertain significance Single submitter
- ARHGEF37 p.Ala397Pro Uncertain significance Single submitter
- ARHGEF37 p.Ala534Gly Uncertain significance Single submitter
- ARHGEF37 p.Ala53Asp Uncertain significance Single submitter
- ARHGEF37 p.Ala573Gly Uncertain significance Single submitter
- ARHGEF37 p.Ala610Thr Uncertain significance Single submitter
- ARHGEF37 p.Arg136Gln Uncertain significance Single submitter
- ARHGEF37 p.Arg143Trp Uncertain significance Single submitter
- ARHGEF37 p.Arg234Gln Uncertain significance Single submitter
- ARHGEF37 p.Arg249Gln Uncertain significance Single submitter
- ARHGEF37 p.Arg249Trp Uncertain significance Single submitter
- ARHGEF37 p.Arg263Met Uncertain significance Single submitter
- ARHGEF37 p.Arg364His Uncertain significance Single submitter
- ARHGEF37 p.Arg392Gln Uncertain significance Single submitter
- ARHGEF37 p.Arg496Cys Uncertain significance Single submitter
- ARHGEF37 p.Arg587Gln Uncertain significance Single submitter
- ARHGEF37 p.Arg59Cys Uncertain significance Single submitter
- ARHGEF37 p.Arg59Leu Uncertain significance Single submitter
- ARHGEF37 p.Arg664Trp Uncertain significance Single submitter
- ARHGEF37 p.Asn239Ser Uncertain significance Single submitter
- ARHGEF37 p.Asn239Tyr Uncertain significance Single submitter
- ARHGEF37 p.Asn309His Uncertain significance Single submitter
- ARHGEF37 p.Asn605Ile Uncertain significance Single submitter
- ARHGEF37 p.Asp77Asn Uncertain significance Single submitter
- ARHGEF37 p.Asp7Asn Uncertain significance Single submitter
- ARHGEF37 p.Gln387Lys Uncertain significance Single submitter
- ARHGEF37 p.Gln434His Uncertain significance Single submitter
- ARHGEF37 p.Gln635Arg Uncertain significance Single submitter
- ARHGEF37 p.Glu138Lys Uncertain significance Single submitter
- ARHGEF37 p.Glu140Lys Uncertain significance Single submitter
- ARHGEF37 p.Glu268Gly Uncertain significance Single submitter
- ARHGEF37 p.Glu314Gln Uncertain significance Single submitter
- ARHGEF37 p.Glu461Asp Uncertain significance Single submitter
- ARHGEF37 p.Gly493Arg Uncertain significance Single submitter
- ARHGEF37 p.Gly543Val Uncertain significance Single submitter
- ARHGEF37 p.Gly653Arg Uncertain significance Single submitter
- ARHGEF37 p.Gly66Arg Uncertain significance Single submitter
- ARHGEF37 p.His241Arg Uncertain significance Single submitter
- ARHGEF37 p.His30Tyr Uncertain significance Single submitter
- ARHGEF37 p.His450Gln Uncertain significance Single submitter
- ARHGEF37 p.His555Gln Uncertain significance Single submitter
- ARHGEF37 p.Ile106Val Uncertain significance Single submitter
- ARHGEF37 p.Ile238Phe Uncertain significance Single submitter
- ARHGEF37 p.Leu141Val Uncertain significance Single submitter
- ARHGEF37 p.Leu243Phe Uncertain significance Single submitter
- ARHGEF37 p.Leu260Arg Uncertain significance Single submitter
- ARHGEF37 p.Leu281Val Uncertain significance Single submitter
- ARHGEF37 p.Leu329Ile Uncertain significance Single submitter
- ARHGEF37 p.Leu354Pro Uncertain significance Single submitter
- ARHGEF37 p.Leu355Phe Uncertain significance Single submitter
- ARHGEF37 p.Lys267Glu Uncertain significance Single submitter
- ARHGEF37 p.Lys377Arg Uncertain significance Single submitter
- ARHGEF37 p.Lys95Gln Uncertain significance Single submitter
- ARHGEF37 p.Phe269Ser Uncertain significance Single submitter
- ARHGEF37 p.Pro305Leu Uncertain significance Single submitter
- ARHGEF37 p.Pro484Ser Uncertain significance Single submitter
- ARHGEF37 p.Pro571Arg Uncertain significance Single submitter
- ARHGEF37 p.Pro656Leu Uncertain significance Single submitter
- ARHGEF37 p.Ser10Thr Uncertain significance Single submitter
- ARHGEF37 p.Ser13Leu Uncertain significance Single submitter
- ARHGEF37 p.Ser221Phe Uncertain significance Single submitter
- ARHGEF37 p.Ser27Leu Uncertain significance Single submitter
- ARHGEF37 p.Ser622Asn Uncertain significance Single submitter
- ARHGEF37 p.Ser83Asn Uncertain significance Single submitter
- ARHGEF37 p.Thr247Asn Uncertain significance Single submitter
- ARHGEF37 p.Thr41Pro Uncertain significance Single submitter
- ARHGEF37 p.Thr426Ile Uncertain significance Single submitter
- ARHGEF37 p.Thr467Met Uncertain significance Single submitter
- ARHGEF37 p.Thr487Ile Uncertain significance Single submitter
- ARHGEF37 p.Thr541Ser Uncertain significance Single submitter
- ARHGEF37 p.Thr552Ser Uncertain significance Single submitter
- ARHGEF37 p.Tyr175Phe Uncertain significance Single submitter
- ARHGEF37 p.Tyr308His Uncertain significance Single submitter
- ARHGEF37 p.Tyr386His Uncertain significance Single submitter
- ARHGEF37 p.Val195Ala Uncertain significance Single submitter
- ARHGEF37 p.Val226Ile Uncertain significance Single submitter
- ARHGEF37 p.Val283Leu Uncertain significance Single submitter
- ARHGEF37 p.Val290Met Uncertain significance Single submitter
- ARHGEF37 p.Val425Ala Uncertain significance Single submitter
- ARHGEF37 p.Val435Met Uncertain significance Single submitter
- ARHGEF37 p.Val614Ala Uncertain significance Single submitter
- ARHGEF37 p.Val667Asp Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ARHGEF37 p.Ala34Gly Uncertain significance Single submitter
- ARHGEF37 p.Arg136Trp Uncertain significance Single submitter
- ARHGEF37 p.Arg216Cys Uncertain significance Single submitter
- ARHGEF37 p.Arg216His Uncertain significance Single submitter
- ARHGEF37 p.Arg216Ser Uncertain significance Single submitter
- ARHGEF37 p.Arg36Trp Uncertain significance Single submitter
- ARHGEF37 p.Arg547His Uncertain significance Single submitter
- ARHGEF37 p.Asp77Gly Uncertain significance Single submitter
- ARHGEF37 p.Gln50Pro Uncertain significance Single submitter
- ARHGEF37 p.Glu340Lys Uncertain significance Single submitter
- ARHGEF37 p.His328Pro Uncertain significance Single submitter
- ARHGEF37 p.Leu38Phe Uncertain significance Single submitter
- ARHGEF37 p.Phe424Leu Uncertain significance Single submitter
- ARHGEF37 p.Pro64Leu Uncertain significance Single submitter
- ARHGEF37 p.Ser44Phe Uncertain significance Single submitter
- ARHGEF37 p.Thr264Lys Uncertain significance Single submitter
- ARHGEF37 p.Trp548Leu Uncertain significance Single submitter
- ARHGEF37 p.Trp643Arg Uncertain significance Single submitter
All ARHGEF37 variants
Likely benign 7
- p.Ala610= Single submitter
- p.Ala610Val Single submitter
- p.Arg143Gln Single submitter
- p.Arg26Lys Single submitter
- p.Arg466Gln Single submitter
- p.His306= Single submitter
- p.Tyr223= Single submitter
Uncertain significance 102
- p.Ala34Gly Single submitter ⚠
- p.Ala353Thr Single submitter ⚠
- p.Ala397Pro Single submitter ⚠
- p.Ala534Gly Single submitter ⚠
- p.Ala53Asp Single submitter ⚠
- p.Ala573Gly Single submitter ⚠
- p.Ala610Thr Single submitter ⚠
- p.Arg136Gln Single submitter ⚠
- p.Arg136Trp Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg216Cys Single submitter ⚠
- p.Arg216His Single submitter ⚠
- p.Arg216Ser Single submitter ⚠
- p.Arg234Gln Single submitter ⚠
- p.Arg249Gln Single submitter ⚠
- p.Arg249Trp Single submitter ⚠
- p.Arg263Met Single submitter ⚠
- p.Arg364His Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Arg392Gln Single submitter ⚠
- p.Arg496Cys Single submitter ⚠
- p.Arg547His Single submitter ⚠
- p.Arg587Gln Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Arg59Leu Single submitter ⚠
- p.Arg664Trp Single submitter ⚠
- p.Asn207Asp Single submitter
- p.Asn239Ser Single submitter ⚠
- p.Asn239Tyr Single submitter ⚠
- p.Asn309His Single submitter ⚠
- p.Asn605Ile Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Asp77Gly Single submitter ⚠
- p.Asp7Asn Single submitter ⚠
- p.Gln387Lys Single submitter ⚠
- p.Gln434His Single submitter ⚠
- p.Gln50Pro Single submitter ⚠
- p.Gln635Arg Single submitter ⚠
- p.Glu138Lys Single submitter ⚠
- p.Glu140Lys Single submitter ⚠
- p.Glu268Gly Single submitter ⚠
- p.Glu314Gln Single submitter ⚠
- p.Glu340Lys Single submitter ⚠
- p.Glu461Asp Single submitter ⚠
- p.Gly493Arg Single submitter ⚠
- p.Gly543Val Single submitter ⚠
- p.Gly653Arg Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.His241Arg Single submitter ⚠
- p.His30Tyr Single submitter ⚠
- p.His328Pro Single submitter ⚠
- p.His450Gln Single submitter ⚠
- p.His555Gln Single submitter ⚠
- p.Ile106Val Single submitter ⚠
- p.Ile238Phe Single submitter ⚠
- p.Leu141Val Single submitter ⚠
- p.Leu243Phe Single submitter ⚠
- p.Leu260Arg Single submitter ⚠
- p.Leu281Val Single submitter ⚠
- p.Leu329Ile Single submitter ⚠
- p.Leu354Pro Single submitter ⚠
- p.Leu355Phe Single submitter ⚠
- p.Leu38Phe Single submitter ⚠
- p.Lys267Glu Single submitter ⚠
- p.Lys377Arg Single submitter ⚠
- p.Lys95Gln Single submitter ⚠
- p.Phe269Ser Single submitter ⚠
- p.Phe424Leu Single submitter ⚠
- p.Pro305Leu Single submitter ⚠
- p.Pro484Ser Single submitter ⚠
- p.Pro571Arg Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Pro656Leu Single submitter ⚠
- p.Ser10Thr Single submitter ⚠
- p.Ser13Leu Single submitter ⚠
- p.Ser221Phe Single submitter ⚠
- p.Ser27Leu Single submitter ⚠
- p.Ser44Phe Single submitter ⚠
- p.Ser622Asn Single submitter ⚠
- p.Ser83Asn Single submitter ⚠
- p.Thr247Asn Single submitter ⚠
- p.Thr264Lys Single submitter ⚠
- p.Thr41Pro Single submitter ⚠
- p.Thr426Ile Single submitter ⚠
- p.Thr467Met Single submitter ⚠
- p.Thr487Ile Single submitter ⚠
- p.Thr541Ser Single submitter ⚠
- p.Thr552Ser Single submitter ⚠
- p.Trp548Leu Single submitter ⚠
- p.Trp643Arg Single submitter ⚠
- p.Tyr175Phe Single submitter ⚠
- p.Tyr308His Single submitter ⚠
- p.Tyr386His Single submitter ⚠
- p.Val195Ala Single submitter ⚠
- p.Val226Ile Single submitter ⚠
- p.Val283Leu Single submitter ⚠
- p.Val290Met Single submitter ⚠
- p.Val425Ala Single submitter ⚠
- p.Val435Met Single submitter ⚠
- p.Val513Met Single submitter
- p.Val614Ala Single submitter ⚠
- p.Val667Asp Single submitter ⚠