ARHGEF38 — 113 ClinVar variants
All ClinVar germline ARHGEF38 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
4 Likely benign · 109 Uncertain significance
Full ARHGEF38 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 91
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF38 p.Ala165Thr Uncertain significance Single submitter
- ARHGEF38 p.Ala165Val Uncertain significance Single submitter
- ARHGEF38 p.Ala194Val Uncertain significance Single submitter
- ARHGEF38 p.Ala404Thr Uncertain significance Single submitter
- ARHGEF38 p.Ala484Thr Uncertain significance Single submitter
- ARHGEF38 p.Ala545Thr Uncertain significance Single submitter
- ARHGEF38 p.Ala595Thr Uncertain significance Single submitter
- ARHGEF38 p.Ala595Val Uncertain significance Single submitter
- ARHGEF38 p.Ala653Gly Uncertain significance Single submitter
- ARHGEF38 p.Ala777Val Uncertain significance Single submitter
- ARHGEF38 p.Arg23Ser Uncertain significance Single submitter
- ARHGEF38 p.Arg243Cys Uncertain significance Single submitter
- ARHGEF38 p.Arg255Trp Uncertain significance Single submitter
- ARHGEF38 p.Arg32Lys Uncertain significance Single submitter
- ARHGEF38 p.Arg417Gly Uncertain significance Single submitter
- ARHGEF38 p.Arg453Gln Uncertain significance Single submitter
- ARHGEF38 p.Arg485Trp Uncertain significance Single submitter
- ARHGEF38 p.Arg574His Uncertain significance Single submitter
- ARHGEF38 p.Arg672Gln Uncertain significance Single submitter
- ARHGEF38 p.Asn111Ser Uncertain significance Single submitter
- ARHGEF38 p.Asn18Ser Uncertain significance Single submitter
- ARHGEF38 p.Asn340Ser Uncertain significance Single submitter
- ARHGEF38 p.Asn470Lys Uncertain significance Single submitter
- ARHGEF38 p.Asn538Ser Uncertain significance Single submitter
- ARHGEF38 p.Asn543Lys Uncertain significance Single submitter
- ARHGEF38 p.Asn602His Uncertain significance Single submitter
- ARHGEF38 p.Asn630Ser Uncertain significance Single submitter
- ARHGEF38 p.Asn703Ser Uncertain significance Single submitter
- ARHGEF38 p.Asp135Asn Uncertain significance Single submitter
- ARHGEF38 p.Asp301Asn Uncertain significance Single submitter
- ARHGEF38 p.Asp306Val Uncertain significance Single submitter
- ARHGEF38 p.Asp392Val Uncertain significance Single submitter
- ARHGEF38 p.Asp393Asn Uncertain significance Single submitter
- ARHGEF38 p.Asp460Val Uncertain significance Single submitter
- ARHGEF38 p.Asp660Asn Uncertain significance Single submitter
- ARHGEF38 p.Asp688Glu Uncertain significance Single submitter
- ARHGEF38 p.Cys366Ser Uncertain significance Single submitter
- ARHGEF38 p.Cys658Arg Uncertain significance Single submitter
- ARHGEF38 p.Cys74Phe Uncertain significance Single submitter
- ARHGEF38 p.Gln368Arg Uncertain significance Single submitter
- ARHGEF38 p.Gln416Leu Uncertain significance Single submitter
- ARHGEF38 p.Glu206Gly Uncertain significance Single submitter
- ARHGEF38 p.Glu253Lys Uncertain significance Single submitter
- ARHGEF38 p.Glu30Gly Uncertain significance Single submitter
- ARHGEF38 p.Glu39Val Uncertain significance Single submitter
- ARHGEF38 p.Glu5Gly Uncertain significance Single submitter
- ARHGEF38 p.Glu73Asp Uncertain significance Single submitter
- ARHGEF38 p.Glu753Asp Uncertain significance Single submitter
- ARHGEF38 p.Glu753Lys Uncertain significance Single submitter
- ARHGEF38 p.Gly432Arg Uncertain significance Single submitter
- ARHGEF38 p.Gly633Val Uncertain significance Single submitter
- ARHGEF38 p.His210Gln Uncertain significance Single submitter
- ARHGEF38 p.His86Arg Uncertain significance Single submitter
- ARHGEF38 p.Ile215Val Uncertain significance Single submitter
- ARHGEF38 p.Ile282Val Uncertain significance Single submitter
- ARHGEF38 p.Leu26Val Uncertain significance Single submitter
- ARHGEF38 p.Leu418His Uncertain significance Single submitter
- ARHGEF38 p.Leu427Pro Uncertain significance Single submitter
- ARHGEF38 p.Leu732Phe Uncertain significance Single submitter
- ARHGEF38 p.Lys97Thr Uncertain significance Single submitter
- ARHGEF38 p.Met237Ile Uncertain significance Single submitter
- ARHGEF38 p.Met237Thr Uncertain significance Single submitter
- ARHGEF38 p.Met382Lys Uncertain significance Single submitter
- ARHGEF38 p.Met68Val Uncertain significance Single submitter
- ARHGEF38 p.Pro515Gln Uncertain significance Single submitter
- ARHGEF38 p.Pro82Arg Uncertain significance Single submitter
- ARHGEF38 p.Ser449Arg Uncertain significance Single submitter
- ARHGEF38 p.Ser449Asn Uncertain significance Single submitter
- ARHGEF38 p.Ser449Gly Uncertain significance Single submitter
- ARHGEF38 p.Ser728Asn Uncertain significance Single submitter
- ARHGEF38 p.Thr160Ile Uncertain significance Single submitter
- ARHGEF38 p.Thr455Met Uncertain significance Single submitter
- ARHGEF38 p.Thr512Ala Uncertain significance Single submitter
- ARHGEF38 p.Thr546Ile Uncertain significance Single submitter
- ARHGEF38 p.Thr596Ala Uncertain significance Single submitter
- ARHGEF38 p.Thr681Ile Uncertain significance Single submitter
- ARHGEF38 p.Thr775Asn Uncertain significance Single submitter
- ARHGEF38 p.Thr79Ser Uncertain significance Single submitter
- ARHGEF38 p.Tyr397Cys Uncertain significance Single submitter
- ARHGEF38 p.Tyr450Cys Uncertain significance Single submitter
- ARHGEF38 p.Tyr466Asn Uncertain significance Single submitter
- ARHGEF38 p.Val121Ile Uncertain significance Single submitter
- ARHGEF38 p.Val144Leu Uncertain significance Single submitter
- ARHGEF38 p.Val144Met Uncertain significance Single submitter
- ARHGEF38 p.Val168Leu Uncertain significance Single submitter
- ARHGEF38 p.Val275Leu Uncertain significance Single submitter
- ARHGEF38 p.Val337Phe Uncertain significance Single submitter
- ARHGEF38 p.Val38Ala Uncertain significance Single submitter
- ARHGEF38 p.Val514Met Uncertain significance Single submitter
- ARHGEF38 p.Val530Gly Uncertain significance Single submitter
- ARHGEF38 p.Val560Gly Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ARHGEF38 p.Arg125Gly Uncertain significance Single submitter
- ARHGEF38 p.Arg623Lys Uncertain significance Single submitter
- ARHGEF38 p.Asp182Tyr Uncertain significance Single submitter
- ARHGEF38 p.Asp607Asn Uncertain significance Single submitter
- ARHGEF38 p.Glu204Gly Uncertain significance Single submitter
- ARHGEF38 p.Ile183Phe Uncertain significance Single submitter
- ARHGEF38 p.Leu174Phe Uncertain significance Single submitter
- ARHGEF38 p.Leu552Pro Uncertain significance Single submitter
- ARHGEF38 p.Lys289Asn Uncertain significance Single submitter
- ARHGEF38 p.Ser364Pro Uncertain significance Single submitter
- ARHGEF38 p.Ser544Arg Uncertain significance Single submitter
- ARHGEF38 p.Tyr643Cys Uncertain significance Single submitter
All ARHGEF38 variants
Likely benign 4
- p.Glu542Asp Single submitter
- p.His195Arg Single submitter
- p.Leu327= Single submitter
- p.Ser24Pro Single submitter
Uncertain significance 109
- p.Ala165Thr Single submitter ⚠
- p.Ala165Val Single submitter ⚠
- p.Ala194Val Single submitter ⚠
- p.Ala404Thr Single submitter ⚠
- p.Ala484Thr Single submitter ⚠
- p.Ala545Thr Single submitter ⚠
- p.Ala595Thr Single submitter ⚠
- p.Ala595Val Single submitter ⚠
- p.Ala653Gly Single submitter ⚠
- p.Ala777Thr Single submitter
- p.Ala777Val Single submitter ⚠
- p.Arg125Gly Single submitter ⚠
- p.Arg23Ser Single submitter ⚠
- p.Arg243Cys Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg32Lys Single submitter ⚠
- p.Arg417Gly Single submitter ⚠
- p.Arg453Gln Single submitter ⚠
- p.Arg485Trp Single submitter ⚠
- p.Arg574His Single submitter ⚠
- p.Arg623Lys Single submitter ⚠
- p.Arg672Gln Single submitter ⚠
- p.Asn111Ser Single submitter ⚠
- p.Asn18Ser Single submitter ⚠
- p.Asn340Ser Single submitter ⚠
- p.Asn470Lys Single submitter ⚠
- p.Asn538Ser Single submitter ⚠
- p.Asn543Lys Single submitter ⚠
- p.Asn602His Single submitter ⚠
- p.Asn630Ser Single submitter ⚠
- p.Asn703Ser Single submitter ⚠
- p.Asn751Ser Single submitter
- p.Asp135Asn Single submitter ⚠
- p.Asp182Tyr Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp306Val Single submitter ⚠
- p.Asp392Val Single submitter ⚠
- p.Asp393Asn Single submitter ⚠
- p.Asp460Val Single submitter ⚠
- p.Asp607Asn Single submitter ⚠
- p.Asp660Asn Single submitter ⚠
- p.Asp688Glu Single submitter ⚠
- p.Cys366Ser Single submitter ⚠
- p.Cys658Arg Single submitter ⚠
- p.Cys74Phe Single submitter ⚠
- p.Gln368Arg Single submitter ⚠
- p.Gln416Leu Single submitter ⚠
- p.Glu204Gly Single submitter ⚠
- p.Glu206Gly Single submitter ⚠
- p.Glu253Lys Single submitter ⚠
- p.Glu30Gly Single submitter ⚠
- p.Glu39Val Single submitter ⚠
- p.Glu5Gly Single submitter ⚠
- p.Glu73Asp Single submitter ⚠
- p.Glu753Asp Single submitter ⚠
- p.Glu753Lys Single submitter ⚠
- p.Gly432Arg Single submitter ⚠
- p.Gly633Val Single submitter ⚠
- p.His191Arg Single submitter
- p.His210Gln Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Ile183Phe Single submitter ⚠
- p.Ile215Val Single submitter ⚠
- p.Ile282Val Single submitter ⚠
- p.Leu174Phe Single submitter ⚠
- p.Leu26Val Single submitter ⚠
- p.Leu418His Single submitter ⚠
- p.Leu423Phe Single submitter
- p.Leu427Pro Single submitter ⚠
- p.Leu552Pro Single submitter ⚠
- p.Leu732Phe Single submitter ⚠
- p.Lys289Asn Single submitter ⚠
- p.Lys435Gln Single submitter
- p.Lys97Thr Single submitter ⚠
- p.Met237Ile Single submitter ⚠
- p.Met237Thr Single submitter ⚠
- p.Met382Lys Single submitter ⚠
- p.Met68Val Single submitter ⚠
- p.Pro515Gln Single submitter ⚠
- p.Pro82Arg Single submitter ⚠
- p.Ser364Pro Single submitter ⚠
- p.Ser449Arg Single submitter ⚠
- p.Ser449Asn Single submitter ⚠
- p.Ser449Gly Single submitter ⚠
- p.Ser544Arg Single submitter ⚠
- p.Ser728Asn Single submitter ⚠
- p.Thr160Ile Single submitter ⚠
- p.Thr455Met Single submitter ⚠
- p.Thr512Ala Single submitter ⚠
- p.Thr546Ile Single submitter ⚠
- p.Thr596Ala Single submitter ⚠
- p.Thr681Ile Single submitter ⚠
- p.Thr775Asn Single submitter ⚠
- p.Thr79Ser Single submitter ⚠
- p.Tyr397Cys Single submitter ⚠
- p.Tyr441Cys Single submitter
- p.Tyr450Cys Single submitter ⚠
- p.Tyr466Asn Single submitter ⚠
- p.Tyr643Cys Single submitter ⚠
- p.Val121Ile Single submitter ⚠
- p.Val144Leu Single submitter ⚠
- p.Val144Met Single submitter ⚠
- p.Val168Leu Single submitter ⚠
- p.Val275Leu Single submitter ⚠
- p.Val337Phe Single submitter ⚠
- p.Val38Ala Single submitter ⚠
- p.Val514Met Single submitter ⚠
- p.Val530Gly Single submitter ⚠
- p.Val560Gly Single submitter ⚠