ARHGEF39 — 58 ClinVar variants
All ClinVar germline ARHGEF39 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
3 Likely benign · 55 Uncertain significance
Full ARHGEF39 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARHGEF39 p.Ala107Val Uncertain significance Single submitter
- ARHGEF39 p.Ala27Ser Uncertain significance Single submitter
- ARHGEF39 p.Ala27Val Uncertain significance Single submitter
- ARHGEF39 p.Arg112Met Uncertain significance Single submitter
- ARHGEF39 p.Arg155Leu Uncertain significance Single submitter
- ARHGEF39 p.Arg193Ser Uncertain significance Single submitter
- ARHGEF39 p.Arg209Cys Uncertain significance Single submitter
- ARHGEF39 p.Arg209His Uncertain significance Single submitter
- ARHGEF39 p.Arg217His Uncertain significance Single submitter
- ARHGEF39 p.Arg23His Uncertain significance Single submitter
- ARHGEF39 p.Arg246His Uncertain significance Single submitter
- ARHGEF39 p.Arg261Gly Uncertain significance Single submitter
- ARHGEF39 p.Arg36Cys Uncertain significance Single submitter
- ARHGEF39 p.Arg98His Uncertain significance Single submitter
- ARHGEF39 p.Asn161Ser Uncertain significance Single submitter
- ARHGEF39 p.Asp147Asn Uncertain significance Single submitter
- ARHGEF39 p.Asp315Glu Uncertain significance Single submitter
- ARHGEF39 p.Gln199Arg Uncertain significance Single submitter
- ARHGEF39 p.Gln201His Uncertain significance Single submitter
- ARHGEF39 p.Glu14Asp Uncertain significance Single submitter
- ARHGEF39 p.Glu14Lys Uncertain significance Single submitter
- ARHGEF39 p.Glu317Lys Uncertain significance Single submitter
- ARHGEF39 p.Gly126Ser Uncertain significance Single submitter
- ARHGEF39 p.Gly126Val Uncertain significance Single submitter
- ARHGEF39 p.His177Arg Uncertain significance Single submitter
- ARHGEF39 p.His206Tyr Uncertain significance Single submitter
- ARHGEF39 p.Ile187Val Uncertain significance Single submitter
- ARHGEF39 p.Ile330Val Uncertain significance Single submitter
- ARHGEF39 p.Leu222Val Uncertain significance Single submitter
- ARHGEF39 p.Leu266Gln Uncertain significance Single submitter
- ARHGEF39 p.Leu3Phe Uncertain significance Single submitter
- ARHGEF39 p.Leu72Val Uncertain significance Single submitter
- ARHGEF39 p.Lys308Met Uncertain significance Single submitter
- ARHGEF39 p.Met257Val Uncertain significance Single submitter
- ARHGEF39 p.Met280Thr Uncertain significance Single submitter
- ARHGEF39 p.Phe249Val Uncertain significance Single submitter
- ARHGEF39 p.Pro260Ser Uncertain significance Single submitter
- ARHGEF39 p.Pro263Leu Uncertain significance Single submitter
- ARHGEF39 p.Ser174Cys Uncertain significance Single submitter
- ARHGEF39 p.Ser188Asn Uncertain significance Single submitter
- ARHGEF39 p.Ser8Trp Uncertain significance Single submitter
- ARHGEF39 p.Thr271Ile Uncertain significance Single submitter
- ARHGEF39 p.Val194Leu Uncertain significance Single submitter
- ARHGEF39 p.Val236Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ARHGEF39 p.Arg246Cys Uncertain significance Single submitter
- ARHGEF39 p.Arg261Trp Uncertain significance Single submitter
- ARHGEF39 p.Gln120Arg Uncertain significance Single submitter
- ARHGEF39 p.Gly241Ala Uncertain significance Single submitter
- ARHGEF39 p.Gly297Asp Uncertain significance Single submitter
- ARHGEF39 p.Gly87Val Uncertain significance Single submitter
- ARHGEF39 p.His99Pro Uncertain significance Single submitter
- ARHGEF39 p.Leu256Phe Uncertain significance Single submitter
- ARHGEF39 p.Trp233Cys Uncertain significance Single submitter
All ARHGEF39 variants
Likely benign 3
- p.Gly136Ser Single submitter
- p.Gly7Ser Single submitter
- p.Ser320Leu Single submitter
Uncertain significance 55
- p.Ala107Val Single submitter ⚠
- p.Ala27Ser Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Arg112Met Single submitter ⚠
- p.Arg129Ser Single submitter
- p.Arg155Leu Single submitter ⚠
- p.Arg193Ser Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg23His Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg261Gly Single submitter ⚠
- p.Arg261Trp Single submitter ⚠
- p.Arg36Cys Single submitter ⚠
- p.Arg98His Single submitter ⚠
- p.Asn161Ser Single submitter ⚠
- p.Asp147Asn Single submitter ⚠
- p.Asp315Glu Single submitter ⚠
- p.Gln120Arg Single submitter ⚠
- p.Gln199Arg Single submitter ⚠
- p.Gln201His Single submitter ⚠
- p.Glu14Asp Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Gly126Ser Single submitter ⚠
- p.Gly126Val Single submitter ⚠
- p.Gly241Ala Single submitter ⚠
- p.Gly297Asp Single submitter ⚠
- p.Gly87Val Single submitter ⚠
- p.His177Arg Single submitter ⚠
- p.His206Tyr Single submitter ⚠
- p.His99Pro Single submitter ⚠
- p.Ile187Val Single submitter ⚠
- p.Ile330Val Single submitter ⚠
- p.Leu133Phe Single submitter
- p.Leu222Val Single submitter ⚠
- p.Leu256Phe Single submitter ⚠
- p.Leu266Gln Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Leu72Val Single submitter ⚠
- p.Lys308Met Single submitter ⚠
- p.Met257Val Single submitter ⚠
- p.Met280Thr Single submitter ⚠
- p.Phe249Val Single submitter ⚠
- p.Pro260Ser Single submitter ⚠
- p.Pro263Leu Single submitter ⚠
- p.Ser174Cys Single submitter ⚠
- p.Ser188Asn Single submitter ⚠
- p.Ser8Trp Single submitter ⚠
- p.Thr271Ile Single submitter ⚠
- p.Trp233Cys Single submitter ⚠
- p.Val194Leu Single submitter ⚠
- p.Val236Met Single submitter ⚠