ARID3A — 122 ClinVar variants
All ClinVar germline ARID3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →
5 Benign · 1 Benign/Likely benign · 8 Likely benign · 108 Uncertain significance
Full ARID3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 106
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 85
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARID3A p.Ala171Thr Uncertain significance Single submitter
- ARID3A p.Ala182Val Uncertain significance Single submitter
- ARID3A p.Ala209Thr Uncertain significance Single submitter
- ARID3A p.Ala384Thr Uncertain significance Single submitter
- ARID3A p.Ala394Val Uncertain significance Single submitter
- ARID3A p.Ala418Val Uncertain significance Single submitter
- ARID3A p.Ala42Pro Uncertain significance Single submitter
- ARID3A p.Ala443Thr Uncertain significance Single submitter
- ARID3A p.Ala487Thr Uncertain significance Single submitter
- ARID3A p.Arg104Gln Uncertain significance Single submitter
- ARID3A p.Arg175Gln Uncertain significance Single submitter
- ARID3A p.Arg175Leu Uncertain significance Single submitter
- ARID3A p.Arg184Cys Uncertain significance Single submitter
- ARID3A p.Arg197Gln Uncertain significance Single submitter
- ARID3A p.Arg197Trp Uncertain significance Single submitter
- ARID3A p.Arg330Trp Uncertain significance Single submitter
- ARID3A p.Arg38Trp Uncertain significance Single submitter
- ARID3A p.Arg40Gln Uncertain significance Single submitter
- ARID3A p.Arg40Trp Uncertain significance Single submitter
- ARID3A p.Arg412Cys Uncertain significance Single submitter
- ARID3A p.Arg412His Uncertain significance Single submitter
- ARID3A p.Arg472Gln Uncertain significance Single submitter
- ARID3A p.Arg476His Uncertain significance Single submitter
- ARID3A p.Arg494Gln Uncertain significance Single submitter
- ARID3A p.Arg53Gln Uncertain significance Single submitter
- ARID3A p.Arg95Trp Uncertain significance Single submitter
- ARID3A p.Asn514Ser Uncertain significance Single submitter
- ARID3A p.Asp30Asn Uncertain significance Single submitter
- ARID3A p.Asp44Asn Uncertain significance Single submitter
- ARID3A p.Asp468His Uncertain significance Single submitter
- ARID3A p.Glu121Lys Uncertain significance Single submitter
- ARID3A p.Glu128Lys Uncertain significance Single submitter
- ARID3A p.Glu501Lys Uncertain significance Single submitter
- ARID3A p.Glu50Lys Uncertain significance Single submitter
- ARID3A p.Glu91Gly Uncertain significance Single submitter
- ARID3A p.Glu96Gln Uncertain significance Single submitter
- ARID3A p.Gly137Arg Uncertain significance Single submitter
- ARID3A p.Gly193Trp Uncertain significance Single submitter
- ARID3A p.Gly206Arg Uncertain significance Single submitter
- ARID3A p.Gly221Cys Uncertain significance Single submitter
- ARID3A p.Gly37Ser Uncertain significance Single submitter
- ARID3A p.Gly388Ser Uncertain significance Single submitter
- ARID3A p.Gly515Ser Uncertain significance Single submitter
- ARID3A p.Gly572Ser Uncertain significance Single submitter
- ARID3A p.Gly79Cys Uncertain significance Single submitter
- ARID3A p.Gly80Ser Uncertain significance Single submitter
- ARID3A p.Ile391Leu Uncertain significance Single submitter
- ARID3A p.Ile391Val Uncertain significance Single submitter
- ARID3A p.Leu417Arg Uncertain significance Single submitter
- ARID3A p.Lys176Glu Uncertain significance Single submitter
- ARID3A p.Lys242Arg Uncertain significance Single submitter
- ARID3A p.Met117Leu Uncertain significance Single submitter
- ARID3A p.Met123Val Uncertain significance Single submitter
- ARID3A p.Pro109Arg Uncertain significance Single submitter
- ARID3A p.Pro174Ser Uncertain significance Single submitter
- ARID3A p.Pro174Thr Uncertain significance Single submitter
- ARID3A p.Pro179Leu Uncertain significance Single submitter
- ARID3A p.Pro198Leu Uncertain significance Single submitter
- ARID3A p.Pro200Leu Uncertain significance Single submitter
- ARID3A p.Pro217Leu Uncertain significance Single submitter
- ARID3A p.Pro28Leu Uncertain significance Single submitter
- ARID3A p.Pro28Ser Uncertain significance Single submitter
- ARID3A p.Pro373Ser Uncertain significance Single submitter
- ARID3A p.Pro43Ser Uncertain significance Single submitter
- ARID3A p.Pro459Leu Uncertain significance Single submitter
- ARID3A p.Pro49Ser Uncertain significance Single submitter
- ARID3A p.Pro538Leu Uncertain significance Single submitter
- ARID3A p.Pro539Leu Uncertain significance Single submitter
- ARID3A p.Pro577Ser Uncertain significance Single submitter
- ARID3A p.Pro75Leu Uncertain significance Single submitter
- ARID3A p.Pro86Ser Uncertain significance Single submitter
- ARID3A p.Pro99Leu Uncertain significance Single submitter
- ARID3A p.Ser362Leu Uncertain significance Single submitter
- ARID3A p.Ser557Asn Uncertain significance Single submitter
- ARID3A p.Ser88Leu Uncertain significance Single submitter
- ARID3A p.Thr542Lys Uncertain significance Single submitter
- ARID3A p.Thr542Met Uncertain significance Single submitter
- ARID3A p.Thr568Ile Uncertain significance Single submitter
- ARID3A p.Val188Ile Uncertain significance Single submitter
- ARID3A p.Val191Leu Uncertain significance Single submitter
- ARID3A p.Val211Ile Uncertain significance Single submitter
- ARID3A p.Val211Leu Uncertain significance Single submitter
- ARID3A p.Val422Gly Uncertain significance Single submitter
- ARID3A p.Val430Leu Uncertain significance Single submitter
- ARID3A p.Val523Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- ARID3A p.Ala68Thr Uncertain significance Single submitter
- ARID3A p.Arg24Trp Uncertain significance Single submitter
- ARID3A p.Arg330Gln Uncertain significance Single submitter
- ARID3A p.Arg472Trp Uncertain significance Single submitter
- ARID3A p.Arg476Cys Uncertain significance Single submitter
- ARID3A p.Arg503Cys Uncertain significance Single submitter
- ARID3A p.Arg56Trp Uncertain significance Single submitter
- ARID3A p.Asn290Lys Uncertain significance Single submitter
- ARID3A p.Asp155Asn Uncertain significance Single submitter
- ARID3A p.Gln253Glu Uncertain significance Single submitter
- ARID3A p.Gln479Arg Uncertain significance Single submitter
- ARID3A p.Gln537His Uncertain significance Single submitter
- ARID3A p.Glu141Lys Uncertain significance Single submitter
- ARID3A p.Glu148Lys Uncertain significance Single submitter
- ARID3A p.Gly137Trp Uncertain significance Single submitter
- ARID3A p.Gly221Asp Uncertain significance Single submitter
- ARID3A p.Gly551Asp Uncertain significance Single submitter
- ARID3A p.Gly551Cys Uncertain significance Single submitter
- ARID3A p.Phe482Ser Uncertain significance Single submitter
- ARID3A p.Thr511Met Uncertain significance Single submitter
- ARID3A p.Tyr361Cys Uncertain significance Single submitter
All ARID3A variants
Benign 5
- c.950+3G>A Multiple submitters
- p.Ala486= Multiple submitters
- p.Glu447= Multiple submitters
- p.Gly551= Multiple submitters
- p.Gly79Ser Single submitter
Benign/Likely benign 1
- p.Ser522= Multiple submitters
Likely benign 8
- p.Ala17= Single submitter
- p.Ala93Thr Single submitter
- p.Arg95Gln Single submitter
- p.Asp155Glu Single submitter
- p.Gly368Ser Single submitter
- p.Gly555Ser Single submitter
- p.Pro205Ser Single submitter
- p.Arg38Gln No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 108
- p.Ala171Thr Single submitter ⚠
- p.Ala182Val Single submitter ⚠
- p.Ala209Thr Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Ala394Val Single submitter ⚠
- p.Ala418Val Single submitter ⚠
- p.Ala42Pro Single submitter ⚠
- p.Ala443Thr Single submitter ⚠
- p.Ala487Thr Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg175Leu Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg197Trp Single submitter ⚠
- p.Arg24Trp Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg38Trp Single submitter ⚠
- p.Arg40Gln Single submitter ⚠
- p.Arg40Trp Single submitter ⚠
- p.Arg412Cys Single submitter ⚠
- p.Arg412His Single submitter ⚠
- p.Arg472Gln Single submitter ⚠
- p.Arg472Trp Single submitter ⚠
- p.Arg476Cys Single submitter ⚠
- p.Arg476His Single submitter ⚠
- p.Arg494Gln Single submitter ⚠
- p.Arg503Cys Single submitter ⚠
- p.Arg53Gln Single submitter ⚠
- p.Arg56Trp Single submitter ⚠
- p.Arg95Trp Single submitter ⚠
- p.Asn290Lys Single submitter ⚠
- p.Asn514Ser Single submitter ⚠
- p.Asp155Asn Single submitter ⚠
- p.Asp30Asn Single submitter ⚠
- p.Asp44Asn Single submitter ⚠
- p.Asp468His Single submitter ⚠
- p.Gln253Glu Single submitter ⚠
- p.Gln479Arg Single submitter ⚠
- p.Gln537His Single submitter ⚠
- p.Glu121Lys Single submitter ⚠
- p.Glu128Lys Single submitter ⚠
- p.Glu141Lys Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Glu226Ter Single submitter
- p.Glu469Lys Single submitter
- p.Glu501Lys Single submitter ⚠
- p.Glu50Lys Single submitter ⚠
- p.Glu91Gly Single submitter ⚠
- p.Glu96Gln Single submitter ⚠
- p.Gly137Arg Single submitter ⚠
- p.Gly137Trp Single submitter ⚠
- p.Gly193Trp Single submitter ⚠
- p.Gly206Arg Single submitter ⚠
- p.Gly221Asp Single submitter ⚠
- p.Gly221Cys Single submitter ⚠
- p.Gly37Ser Single submitter ⚠
- p.Gly388Ser Single submitter ⚠
- p.Gly515Ser Single submitter ⚠
- p.Gly551Asp Single submitter ⚠
- p.Gly551Cys Single submitter ⚠
- p.Gly572Ser Single submitter ⚠
- p.Gly79Cys Single submitter ⚠
- p.Gly80Ser Single submitter ⚠
- p.Ile391Leu Single submitter ⚠
- p.Ile391Val Single submitter ⚠
- p.Leu417Arg Single submitter ⚠
- p.Lys176Glu Single submitter ⚠
- p.Lys242Arg Single submitter ⚠
- p.Met117Leu Single submitter ⚠
- p.Met123Val Single submitter ⚠
- p.Phe482Ser Single submitter ⚠
- p.Pro109Arg Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro174Thr Single submitter ⚠
- p.Pro179Leu Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro200Leu Single submitter ⚠
- p.Pro217Leu Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Pro373Ser Single submitter ⚠
- p.Pro43Ser Single submitter ⚠
- p.Pro459Leu Single submitter ⚠
- p.Pro49Ser Single submitter ⚠
- p.Pro538Leu Single submitter ⚠
- p.Pro539Leu Single submitter ⚠
- p.Pro577Ser Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Pro99Leu Single submitter ⚠
- p.Ser362Leu Single submitter ⚠
- p.Ser557Asn Single submitter ⚠
- p.Ser88Leu Single submitter ⚠
- p.Thr511Met Single submitter ⚠
- p.Thr542Lys Single submitter ⚠
- p.Thr542Met Single submitter ⚠
- p.Thr568Ile Single submitter ⚠
- p.Tyr361Cys Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val191Leu Single submitter ⚠
- p.Val211Ile Single submitter ⚠
- p.Val211Leu Single submitter ⚠
- p.Val422Gly Single submitter ⚠
- p.Val430Leu Single submitter ⚠
- p.Val523Met Single submitter ⚠