ARID3B — 74 ClinVar variants
All ClinVar germline ARID3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
3 Benign · 1 Likely benign · 70 Uncertain significance
Full ARID3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARID3B p.Ala164Thr Uncertain significance Single submitter
- ARID3B p.Ala342Val Uncertain significance Single submitter
- ARID3B p.Ala348Thr Uncertain significance Single submitter
- ARID3B p.Ala410Gly Uncertain significance Single submitter
- ARID3B p.Ala419Thr Uncertain significance Single submitter
- ARID3B p.Ala531Thr Uncertain significance Single submitter
- ARID3B p.Ala552Thr Uncertain significance Single submitter
- ARID3B p.Arg129His Uncertain significance Single submitter
- ARID3B p.Arg133Gly Uncertain significance Single submitter
- ARID3B p.Arg200Gly Uncertain significance Single submitter
- ARID3B p.Arg204Gln Uncertain significance Single submitter
- ARID3B p.Arg328Trp Uncertain significance Single submitter
- ARID3B p.Arg361Cys Uncertain significance Single submitter
- ARID3B p.Arg402Cys Uncertain significance Single submitter
- ARID3B p.Arg417Gly Uncertain significance Single submitter
- ARID3B p.Arg417Trp Uncertain significance Single submitter
- ARID3B p.Arg427Gln Uncertain significance Single submitter
- ARID3B p.Arg462Gln Uncertain significance Single submitter
- ARID3B p.Arg476Lys Uncertain significance Single submitter
- ARID3B p.Arg71Thr Uncertain significance Single submitter
- ARID3B p.Asn485Asp Uncertain significance Single submitter
- ARID3B p.Asp100Asn Uncertain significance Single submitter
- ARID3B p.Asp179Glu Uncertain significance Single submitter
- ARID3B p.Asp320Val Uncertain significance Single submitter
- ARID3B p.Gln130Glu Uncertain significance Single submitter
- ARID3B p.Gln17Glu Uncertain significance Single submitter
- ARID3B p.Gln17His Uncertain significance Single submitter
- ARID3B p.Gln5Glu Uncertain significance Single submitter
- ARID3B p.Gln5Lys Uncertain significance Single submitter
- ARID3B p.Glu435Lys Uncertain significance Single submitter
- ARID3B p.Glu94Lys Uncertain significance Single submitter
- ARID3B p.Gly350Ala Uncertain significance Single submitter
- ARID3B p.Gly350Arg Uncertain significance Single submitter
- ARID3B p.Gly372Ser Uncertain significance Single submitter
- ARID3B p.Gly472Ser Uncertain significance Single submitter
- ARID3B p.Ile236Thr Uncertain significance Single submitter
- ARID3B p.Ile491Ser Uncertain significance Single submitter
- ARID3B p.Leu182Pro Uncertain significance Single submitter
- ARID3B p.Leu355Pro Uncertain significance Single submitter
- ARID3B p.Leu518Val Uncertain significance Single submitter
- ARID3B p.Leu52Phe Uncertain significance Single submitter
- ARID3B p.Lys159Glu Uncertain significance Single submitter
- ARID3B p.Lys306Thr Uncertain significance Single submitter
- ARID3B p.Lys45Asn Uncertain significance Single submitter
- ARID3B p.Met466Thr Uncertain significance Single submitter
- ARID3B p.Phe226Ile Uncertain significance Single submitter
- ARID3B p.Pro136Leu Uncertain significance Single submitter
- ARID3B p.Pro147Ser Uncertain significance Single submitter
- ARID3B p.Pro166Ala Uncertain significance Single submitter
- ARID3B p.Pro166Leu Uncertain significance Single submitter
- ARID3B p.Pro329Ser Uncertain significance Single submitter
- ARID3B p.Pro393Thr Uncertain significance Single submitter
- ARID3B p.Pro91Leu Uncertain significance Single submitter
- ARID3B p.Ser167Phe Uncertain significance Single submitter
- ARID3B p.Ser430Leu Uncertain significance Single submitter
- ARID3B p.Ser439Leu Uncertain significance Single submitter
- ARID3B p.Ser532Gly Uncertain significance Single submitter
- ARID3B p.Ser54Phe Uncertain significance Single submitter
- ARID3B p.Ser551Gly Uncertain significance Single submitter
- ARID3B p.Thr549Ile Uncertain significance Single submitter
- ARID3B p.Val124Gly Uncertain significance Single submitter
- ARID3B p.Val168Ala Uncertain significance Single submitter
- ARID3B p.Val407Leu Uncertain significance Single submitter
- ARID3B p.Val407Met Uncertain significance Single submitter
- ARID3B p.Val449Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARID3B variants
Likely benign 1
- p.Val227Ile Single submitter
Uncertain significance 70
- p.Ala164Thr Single submitter ⚠
- p.Ala342Val Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala410Gly Single submitter ⚠
- p.Ala419Thr Single submitter ⚠
- p.Ala531Thr Single submitter ⚠
- p.Ala552Thr Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg133Gly Single submitter ⚠
- p.Arg200Gly Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg328Trp Single submitter ⚠
- p.Arg361Cys Single submitter ⚠
- p.Arg402Cys Single submitter ⚠
- p.Arg417Gly Single submitter ⚠
- p.Arg417Trp Single submitter ⚠
- p.Arg427Gln Single submitter ⚠
- p.Arg447Cys Single submitter
- p.Arg462Gln Single submitter ⚠
- p.Arg476Lys Single submitter ⚠
- p.Arg71Thr Single submitter ⚠
- p.Asn485Asp Single submitter ⚠
- p.Asp100Asn Single submitter ⚠
- p.Asp179Glu Single submitter ⚠
- p.Asp320Val Single submitter ⚠
- p.Gln130Glu Single submitter ⚠
- p.Gln17Glu Single submitter ⚠
- p.Gln17His Single submitter ⚠
- p.Gln5Glu Single submitter ⚠
- p.Gln5Lys Single submitter ⚠
- p.Glu258Lys Single submitter
- p.Glu435Lys Single submitter ⚠
- p.Glu94Lys Single submitter ⚠
- p.Gly350Ala Single submitter ⚠
- p.Gly350Arg Single submitter ⚠
- p.Gly372Ser Single submitter ⚠
- p.Gly472Ser Single submitter ⚠
- p.Ile236Thr Single submitter ⚠
- p.Ile270Asn Single submitter ⚠
- p.Ile491Ser Single submitter ⚠
- p.Leu182Pro Single submitter ⚠
- p.Leu355Pro Single submitter ⚠
- p.Leu518Val Single submitter ⚠
- p.Leu52Phe Single submitter ⚠
- p.Lys159Glu Single submitter ⚠
- p.Lys208Glu Single submitter ⚠
- p.Lys306Thr Single submitter ⚠
- p.Lys45Asn Single submitter ⚠
- p.Met466Thr Single submitter ⚠
- p.Phe226Ile Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro147Ser Single submitter ⚠
- p.Pro166Ala Single submitter ⚠
- p.Pro166Leu Single submitter ⚠
- p.Pro329Ser Single submitter ⚠
- p.Pro393Thr Single submitter ⚠
- p.Pro91Leu Single submitter ⚠
- p.Ser167Phe Single submitter ⚠
- p.Ser430Leu Single submitter ⚠
- p.Ser439Leu Single submitter ⚠
- p.Ser532Gly Single submitter ⚠
- p.Ser54Phe Single submitter ⚠
- p.Ser551Gly Single submitter ⚠
- p.Thr549Ile Single submitter ⚠
- p.Trp190Arg Single submitter ⚠
- p.Val124Gly Single submitter ⚠
- p.Val168Ala Single submitter ⚠
- p.Val407Leu Single submitter ⚠
- p.Val407Met Single submitter ⚠
- p.Val449Met Single submitter ⚠