ARID3C — 72 ClinVar variants
All ClinVar germline ARID3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Likely benign · 71 Uncertain significance
Full ARID3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARID3C p.Ala13Val Uncertain significance Single submitter
- ARID3C p.Ala228Val Uncertain significance Single submitter
- ARID3C p.Ala249Val Uncertain significance Single submitter
- ARID3C p.Ala258Val Uncertain significance Single submitter
- ARID3C p.Ala323Val Uncertain significance Single submitter
- ARID3C p.Ala391Asp Uncertain significance Single submitter
- ARID3C p.Ala40Asp Uncertain significance Single submitter
- ARID3C p.Ala56Asp Uncertain significance Single submitter
- ARID3C p.Arg11Gly Uncertain significance Single submitter
- ARID3C p.Arg11Trp Uncertain significance Single submitter
- ARID3C p.Arg136Ser Uncertain significance Single submitter
- ARID3C p.Arg205Pro Uncertain significance Single submitter
- ARID3C p.Arg310Trp Uncertain significance Single submitter
- ARID3C p.Arg343His Uncertain significance Single submitter
- ARID3C p.Arg352Gln Uncertain significance Single submitter
- ARID3C p.Arg352Trp Uncertain significance Single submitter
- ARID3C p.Arg385Cys Uncertain significance Single submitter
- ARID3C p.Arg386Cys Uncertain significance Single submitter
- ARID3C p.Arg63Gln Uncertain significance Single submitter
- ARID3C p.Asn135Asp Uncertain significance Single submitter
- ARID3C p.Asn295Lys Uncertain significance Single submitter
- ARID3C p.Asp218Asn Uncertain significance Single submitter
- ARID3C p.Cys278Gly Uncertain significance Single submitter
- ARID3C p.Gln260His Uncertain significance Single submitter
- ARID3C p.Glu311Lys Uncertain significance Single submitter
- ARID3C p.Glu97Lys Uncertain significance Single submitter
- ARID3C p.Gly131Glu Uncertain significance Single submitter
- ARID3C p.Gly17Arg Uncertain significance Single submitter
- ARID3C p.Gly17Val Uncertain significance Single submitter
- ARID3C p.Gly394Ser Uncertain significance Single submitter
- ARID3C p.His35Tyr Uncertain significance Single submitter
- ARID3C p.Leu176Phe Uncertain significance Single submitter
- ARID3C p.Leu234His Uncertain significance Single submitter
- ARID3C p.Leu300Pro Uncertain significance Single submitter
- ARID3C p.Met140Thr Uncertain significance Single submitter
- ARID3C p.Phe126Leu Uncertain significance Single submitter
- ARID3C p.Pro24Leu Uncertain significance Single submitter
- ARID3C p.Pro27Arg Uncertain significance Single submitter
- ARID3C p.Pro28Leu Uncertain significance Single submitter
- ARID3C p.Pro328Ser Uncertain significance Single submitter
- ARID3C p.Pro398Ser Uncertain significance Single submitter
- ARID3C p.Pro400Ser Uncertain significance Single submitter
- ARID3C p.Pro401Ser Uncertain significance Single submitter
- ARID3C p.Pro406Ala Uncertain significance Single submitter
- ARID3C p.Pro412Ser Uncertain significance Single submitter
- ARID3C p.Pro41His Uncertain significance Single submitter
- ARID3C p.Pro41Ser Uncertain significance Single submitter
- ARID3C p.Pro78Ser Uncertain significance Single submitter
- ARID3C p.Pro90Ala Uncertain significance Single submitter
- ARID3C p.Ser184Trp Uncertain significance Single submitter
- ARID3C p.Ser362Arg Uncertain significance Single submitter
- ARID3C p.Ser365Cys Uncertain significance Single submitter
- ARID3C p.Ser85Leu Uncertain significance Single submitter
- ARID3C p.Thr270Ile Uncertain significance Single submitter
- ARID3C p.Thr37Asn Uncertain significance Single submitter
- ARID3C p.Thr37Ser Uncertain significance Single submitter
- ARID3C p.Tyr200His Uncertain significance Single submitter
- ARID3C p.Tyr229His Uncertain significance Single submitter
- ARID3C p.Tyr378Cys Uncertain significance Single submitter
- ARID3C p.Val161Leu Uncertain significance Single submitter
- ARID3C p.Val324Met Uncertain significance Single submitter
- ARID3C p.Val48Ala Uncertain significance Single submitter
- ARID3C p.Val48Gly Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ARID3C p.Arg226His Uncertain significance Single submitter
- ARID3C p.Asp121Asn Uncertain significance Single submitter
- ARID3C p.Glu101Lys Uncertain significance Single submitter
- ARID3C p.Gly159Ser Uncertain significance Single submitter
- ARID3C p.Thr99Asn Uncertain significance Single submitter
- ARID3C p.Val137Leu Uncertain significance Single submitter
All ARID3C variants
Likely benign 1
- p.Pro256Ser No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 71
- p.Ala13Val Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala249Val Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala323Val Single submitter ⚠
- p.Ala391Asp Single submitter ⚠
- p.Ala40Asp Single submitter ⚠
- p.Ala56Asp Single submitter ⚠
- p.Arg11Gly Single submitter ⚠
- p.Arg11Trp Single submitter ⚠
- p.Arg136Ser Single submitter ⚠
- p.Arg205Pro Single submitter ⚠
- p.Arg226His Single submitter ⚠
- p.Arg310Trp Single submitter ⚠
- p.Arg343His Single submitter ⚠
- p.Arg352Gln Single submitter ⚠
- p.Arg352Trp Single submitter ⚠
- p.Arg385Cys Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Asn135Asp Single submitter ⚠
- p.Asn295Lys Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp218Asn Single submitter ⚠
- p.Cys278Gly Single submitter ⚠
- p.Gln260His Single submitter ⚠
- p.Glu101Lys Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Glu97Lys Single submitter ⚠
- p.Gly131Glu Single submitter ⚠
- p.Gly159Ser Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly17Val Single submitter ⚠
- p.Gly394Ser Single submitter ⚠
- p.His35Tyr Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Leu234His Single submitter ⚠
- p.Leu300Pro Single submitter ⚠
- p.Met140Thr Single submitter ⚠
- p.Met194Val Single submitter
- p.Phe126Leu Single submitter ⚠
- p.Pro210Ala Single submitter
- p.Pro24Leu Single submitter ⚠
- p.Pro27Arg Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro328Ser Single submitter ⚠
- p.Pro398Ser Single submitter ⚠
- p.Pro400Ser Single submitter ⚠
- p.Pro401Ser Single submitter ⚠
- p.Pro406Ala Single submitter ⚠
- p.Pro412Ser Single submitter ⚠
- p.Pro41His Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Pro78Ser Single submitter ⚠
- p.Pro90Ala Single submitter ⚠
- p.Ser184Trp Single submitter ⚠
- p.Ser362Arg Single submitter ⚠
- p.Ser365Cys Single submitter ⚠
- p.Ser85Leu Single submitter ⚠
- p.Thr270Ile Single submitter ⚠
- p.Thr37Asn Single submitter ⚠
- p.Thr37Ser Single submitter ⚠
- p.Thr99Asn Single submitter ⚠
- p.Tyr200His Single submitter ⚠
- p.Tyr229His Single submitter ⚠
- p.Tyr378Cys Single submitter ⚠
- p.Val137Leu Single submitter ⚠
- p.Val161Leu Single submitter ⚠
- p.Val324Met Single submitter ⚠
- p.Val48Ala Single submitter ⚠
- p.Val48Gly Single submitter ⚠