ARID4A — 136 ClinVar variants
All ClinVar germline ARID4A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 130 flagged for review →
1 Likely pathogenic · 1 Conflicting · 4 Likely benign · 130 Uncertain significance
Full ARID4A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 130
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 94
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARID4A p.Ala1033Ser Uncertain significance Single submitter
- ARID4A p.Ala1046Ser Uncertain significance Single submitter
- ARID4A p.Ala1054Ser Uncertain significance Single submitter
- ARID4A p.Ala1084Ser Uncertain significance Single submitter
- ARID4A p.Ala1096Val Uncertain significance Single submitter
- ARID4A p.Ala1227Val Uncertain significance Single submitter
- ARID4A p.Ala1229Gly Uncertain significance Single submitter
- ARID4A p.Ala1229Thr Uncertain significance Single submitter
- ARID4A p.Ala27Thr Uncertain significance Single submitter
- ARID4A p.Ala786Gly Uncertain significance Single submitter
- ARID4A p.Ala817Gly Uncertain significance Single submitter
- ARID4A p.Ala841Pro Uncertain significance Single submitter
- ARID4A p.Ala916Val Uncertain significance Single submitter
- ARID4A p.Ala994Gly Uncertain significance Single submitter
- ARID4A p.Arg103Cys Uncertain significance Single submitter
- ARID4A p.Arg1065Lys Uncertain significance Single submitter
- ARID4A p.Arg1068Thr Uncertain significance Single submitter
- ARID4A p.Arg1089His Uncertain significance Single submitter
- ARID4A p.Arg1157Thr Uncertain significance Single submitter
- ARID4A p.Arg258Ser Uncertain significance Single submitter
- ARID4A p.Arg475Gly Uncertain significance Single submitter
- ARID4A p.Arg618Ser Uncertain significance Single submitter
- ARID4A p.Asn1079Ser Uncertain significance Single submitter
- ARID4A p.Asn314Ser Uncertain significance Single submitter
- ARID4A p.Asn404Asp Uncertain significance Single submitter
- ARID4A p.Asn728Lys Uncertain significance Single submitter
- ARID4A p.Asn815Ile Uncertain significance Single submitter
- ARID4A p.Asn986Lys Uncertain significance Single submitter
- ARID4A p.Asp262Ala Uncertain significance Single submitter
- ARID4A p.Asp476His Uncertain significance Single submitter
- ARID4A p.Asp491Asn Uncertain significance Single submitter
- ARID4A p.Asp560Asn Uncertain significance Single submitter
- ARID4A p.Asp694Glu Uncertain significance Single submitter
- ARID4A p.Asp888Val Uncertain significance Single submitter
- ARID4A p.Cys1123Arg Uncertain significance Single submitter
- ARID4A p.Cys889Tyr Uncertain significance Single submitter
- ARID4A p.Gln1063Arg Uncertain significance Single submitter
- ARID4A p.Gln1072Arg Uncertain significance Single submitter
- ARID4A p.Gln920His Uncertain significance Single submitter
- ARID4A p.Glu285Lys Uncertain significance Single submitter
- ARID4A p.Glu485Lys Uncertain significance Single submitter
- ARID4A p.Glu655Lys Uncertain significance Single submitter
- ARID4A p.Glu781Val Uncertain significance Single submitter
- ARID4A p.Glu909Ala Uncertain significance Single submitter
- ARID4A p.Glu944Gly Uncertain significance Single submitter
- ARID4A p.Gly520Arg Uncertain significance Single submitter
- ARID4A p.Gly604Arg Uncertain significance Single submitter
- ARID4A p.Gly891Val Uncertain significance Single submitter
- ARID4A p.His1160Arg Uncertain significance Single submitter
- ARID4A p.His1226Arg Uncertain significance Single submitter
- ARID4A p.His130Arg Uncertain significance Single submitter
- ARID4A p.Ile1027Thr Uncertain significance Single submitter
- ARID4A p.Ile1027Val Uncertain significance Single submitter
- ARID4A p.Ile1061Thr Uncertain significance Single submitter
- ARID4A p.Ile1148Val Uncertain significance Single submitter
- ARID4A p.Ile234Val Uncertain significance Single submitter
- ARID4A p.Ile268Val Uncertain significance Single submitter
- ARID4A p.Ile451Asn Uncertain significance Single submitter
- ARID4A p.Ile484Asn Uncertain significance Single submitter
- ARID4A p.Ile869Thr Uncertain significance Single submitter
- ARID4A p.Leu235Val Uncertain significance Single submitter
- ARID4A p.Leu715Val Uncertain significance Single submitter
- ARID4A p.Leu833Ser Uncertain significance Single submitter
- ARID4A p.Lys1122Thr Uncertain significance Single submitter
- ARID4A p.Lys139Arg Uncertain significance Single submitter
- ARID4A p.Lys208Gln Uncertain significance Single submitter
- ARID4A p.Lys492Glu Uncertain significance Single submitter
- ARID4A p.Lys513Thr Uncertain significance Single submitter
- ARID4A p.Lys800Thr Uncertain significance Single submitter
- ARID4A p.Lys943Glu Uncertain significance Single submitter
- ARID4A p.Met1231Thr Uncertain significance Single submitter
- ARID4A p.Met428Arg Uncertain significance Single submitter
- ARID4A p.Met428Val Uncertain significance Single submitter
- ARID4A p.Met679Val Uncertain significance Single submitter
- ARID4A p.Met875Lys Uncertain significance Single submitter
- ARID4A p.Met949Val Uncertain significance Single submitter
- ARID4A p.Phe1172Val Uncertain significance Single submitter
- ARID4A p.Phe772Leu Uncertain significance Single submitter
- ARID4A p.Phe900Cys Uncertain significance Single submitter
- ARID4A p.Phe930Leu Uncertain significance Single submitter
- ARID4A p.Pro1146Leu Uncertain significance Single submitter
- ARID4A p.Pro439Ala Uncertain significance Single submitter
- ARID4A p.Pro680Leu Uncertain significance Single submitter
- ARID4A p.Pro821Thr Uncertain significance Single submitter
- ARID4A p.Ser1031Gly Uncertain significance Single submitter
- ARID4A p.Ser1055Pro Uncertain significance Single submitter
- ARID4A p.Ser863Pro Uncertain significance Single submitter
- ARID4A p.Ser864Leu Uncertain significance Single submitter
- ARID4A p.Thr498Ile Uncertain significance Single submitter
- ARID4A p.Thr674Ala Uncertain significance Single submitter
- ARID4A p.Tyr399Phe Uncertain significance Single submitter
- ARID4A p.Tyr681Cys Uncertain significance Single submitter
- ARID4A p.Val38Ile Uncertain significance Single submitter
- ARID4A p.Val980Ile Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- ARID4A p.Ala225Glu Uncertain significance Single submitter
- ARID4A p.Ala225Thr Uncertain significance Single submitter
- ARID4A p.Ala4Val Uncertain significance Single submitter
- ARID4A p.Arg1089Cys Uncertain significance Single submitter
- ARID4A p.Arg1093Gln Uncertain significance Single submitter
- ARID4A p.Arg857Trp Uncertain significance Single submitter
- ARID4A p.Arg99Gln Uncertain significance Single submitter
- ARID4A p.Asn331Ser Uncertain significance Single submitter
- ARID4A p.Asn342Ser Uncertain significance Single submitter
- ARID4A p.Asn404His Uncertain significance Single submitter
- ARID4A p.Asn724Tyr Uncertain significance Single submitter
- ARID4A p.Asn736His Uncertain significance Single submitter
- ARID4A p.Asp340Val Uncertain significance Single submitter
- ARID4A p.Glu280Val Uncertain significance Single submitter
- ARID4A p.Glu419Gly Uncertain significance Single submitter
- ARID4A p.Glu458Gly Uncertain significance Single submitter
- ARID4A p.Glu761Gln Uncertain significance Single submitter
- ARID4A p.Glu764Ala Uncertain significance Single submitter
- ARID4A p.Glu872Ala Uncertain significance Single submitter
- ARID4A p.Gly794Ala Uncertain significance Single submitter
- ARID4A p.Gly794Arg Uncertain significance Single submitter
- ARID4A p.Leu148Phe Uncertain significance Single submitter
- ARID4A p.Leu336Val Uncertain significance Single submitter
- ARID4A p.Lys207Arg Uncertain significance Single submitter
- ARID4A p.Lys345Arg Uncertain significance Single submitter
- ARID4A p.Lys858Asn Uncertain significance Single submitter
- ARID4A p.Pro238Leu Uncertain significance Single submitter
- ARID4A p.Ser598Arg Uncertain significance Single submitter
- ARID4A p.Ser840Phe Uncertain significance Single submitter
- ARID4A p.Thr1090Ala Uncertain significance Single submitter
- ARID4A p.Thr1124Ile Uncertain significance Single submitter
- ARID4A p.Thr133Ser Uncertain significance Single submitter
- ARID4A p.Thr205Ala Uncertain significance Single submitter
- ARID4A p.Thr68Ser Uncertain significance Single submitter
- ARID4A p.Val1019Ala Uncertain significance Single submitter
- ARID4A p.Val443Leu Uncertain significance Single submitter
All ARID4A variants
Likely pathogenic 1
- p.Glu872Ter No assertion criteria plasma cell myeloma
Conflicting classifications of pathogenicity 1
- c.3211+1G>A Single submitter
Likely benign 4
- p.Ala979Val Single submitter
- p.Asn236Ser Single submitter
- p.Met752Leu Single submitter
- p.Val1019Ile Single submitter
Uncertain significance 130
- p.Ala1033Ser Single submitter ⚠
- p.Ala1046Ser Single submitter ⚠
- p.Ala1054Ser Single submitter ⚠
- p.Ala1084Ser Single submitter ⚠
- p.Ala1096Val Single submitter ⚠
- p.Ala1227Val Single submitter ⚠
- p.Ala1229Gly Single submitter ⚠
- p.Ala1229Thr Single submitter ⚠
- p.Ala225Glu Single submitter ⚠
- p.Ala225Thr Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Ala786Gly Single submitter ⚠
- p.Ala817Gly Single submitter ⚠
- p.Ala841Pro Single submitter ⚠
- p.Ala916Val Single submitter ⚠
- p.Ala994Gly Single submitter ⚠
- p.Arg103Cys Single submitter ⚠
- p.Arg1065Lys Single submitter ⚠
- p.Arg1068Thr Single submitter ⚠
- p.Arg1089Cys Single submitter ⚠
- p.Arg1089His Single submitter ⚠
- p.Arg1093Gln Single submitter ⚠
- p.Arg1157Thr Single submitter ⚠
- p.Arg258Ser Single submitter ⚠
- p.Arg475Gly Single submitter ⚠
- p.Arg618Ser Single submitter ⚠
- p.Arg857Trp Single submitter ⚠
- p.Arg99Gln Single submitter ⚠
- p.Asn1079Ser Single submitter ⚠
- p.Asn314Ser Single submitter ⚠
- p.Asn331Ser Single submitter ⚠
- p.Asn342Ser Single submitter ⚠
- p.Asn404Asp Single submitter ⚠
- p.Asn404His Single submitter ⚠
- p.Asn724Tyr Single submitter ⚠
- p.Asn728Lys Single submitter ⚠
- p.Asn736His Single submitter ⚠
- p.Asn815Ile Single submitter ⚠
- p.Asn986Lys Single submitter ⚠
- p.Asp262Ala Single submitter ⚠
- p.Asp340Val Single submitter ⚠
- p.Asp476His Single submitter ⚠
- p.Asp491Asn Single submitter ⚠
- p.Asp560Asn Single submitter ⚠
- p.Asp694Glu Single submitter ⚠
- p.Asp888Val Single submitter ⚠
- p.Cys1123Arg Single submitter ⚠
- p.Cys889Tyr Single submitter ⚠
- p.Gln1063Arg Single submitter ⚠
- p.Gln1072Arg Single submitter ⚠
- p.Gln920His Single submitter ⚠
- p.Glu280Val Single submitter ⚠
- p.Glu285Lys Single submitter ⚠
- p.Glu419Gly Single submitter ⚠
- p.Glu458Gly Single submitter ⚠
- p.Glu485Lys Single submitter ⚠
- p.Glu655Lys Single submitter ⚠
- p.Glu761Gln Single submitter ⚠
- p.Glu764Ala Single submitter ⚠
- p.Glu781Val Single submitter ⚠
- p.Glu872Ala Single submitter ⚠
- p.Glu909Ala Single submitter ⚠
- p.Glu944Gly Single submitter ⚠
- p.Gly520Arg Single submitter ⚠
- p.Gly604Arg Single submitter ⚠
- p.Gly794Ala Single submitter ⚠
- p.Gly794Arg Single submitter ⚠
- p.Gly891Val Single submitter ⚠
- p.His1160Arg Single submitter ⚠
- p.His1226Arg Single submitter ⚠
- p.His130Arg Single submitter ⚠
- p.Ile1027Thr Single submitter ⚠
- p.Ile1027Val Single submitter ⚠
- p.Ile1061Thr Single submitter ⚠
- p.Ile1148Val Single submitter ⚠
- p.Ile234Val Single submitter ⚠
- p.Ile268Val Single submitter ⚠
- p.Ile451Asn Single submitter ⚠
- p.Ile484Asn Single submitter ⚠
- p.Ile869Thr Single submitter ⚠
- p.Leu148Phe Single submitter ⚠
- p.Leu235Val Single submitter ⚠
- p.Leu336Val Single submitter ⚠
- p.Leu715Val Single submitter ⚠
- p.Leu833Ser Single submitter ⚠
- p.Lys1122Thr Single submitter ⚠
- p.Lys139Arg Single submitter ⚠
- p.Lys207Arg Single submitter ⚠
- p.Lys208Gln Single submitter ⚠
- p.Lys345Arg Single submitter ⚠
- p.Lys492Glu Single submitter ⚠
- p.Lys513Thr Single submitter ⚠
- p.Lys800Thr Single submitter ⚠
- p.Lys858Asn Single submitter ⚠
- p.Lys943Glu Single submitter ⚠
- p.Met1231Thr Single submitter ⚠
- p.Met428Arg Single submitter ⚠
- p.Met428Val Single submitter ⚠
- p.Met679Val Single submitter ⚠
- p.Met875Lys Single submitter ⚠
- p.Met949Val Single submitter ⚠
- p.Phe1172Val Single submitter ⚠
- p.Phe772Leu Single submitter ⚠
- p.Phe900Cys Single submitter ⚠
- p.Phe930Leu Single submitter ⚠
- p.Pro1146Leu Single submitter ⚠
- p.Pro238Leu Single submitter ⚠
- p.Pro439Ala Single submitter ⚠
- p.Pro680Leu Single submitter ⚠
- p.Pro821Thr Single submitter ⚠
- p.Ser1031Gly Single submitter ⚠
- p.Ser1055Pro Single submitter ⚠
- p.Ser598Arg Single submitter ⚠
- p.Ser840Phe Single submitter ⚠
- p.Ser863Pro Single submitter ⚠
- p.Ser864Leu Single submitter ⚠
- p.Thr1090Ala Single submitter ⚠
- p.Thr1124Ile Single submitter ⚠
- p.Thr133Ser Single submitter ⚠
- p.Thr205Ala Single submitter ⚠
- p.Thr498Ile Single submitter ⚠
- p.Thr674Ala Single submitter ⚠
- p.Thr68Ser Single submitter ⚠
- p.Tyr399Phe Single submitter ⚠
- p.Tyr681Cys Single submitter ⚠
- p.Val1019Ala Single submitter ⚠
- p.Val38Ile Single submitter ⚠
- p.Val443Leu Single submitter ⚠
- p.Val980Ile Single submitter ⚠