ARID4B — 135 ClinVar variants

All ClinVar germline ARID4B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 126 flagged for review →

1 Conflicting · 1 Benign · 5 Likely benign · 128 Uncertain significance

Full ARID4B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 126

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

ARID4B p.Thr1182Ile Conflicting Single submitter

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 17

The independent predictors disagree with each other — read with care.

All ARID4B variants

Conflicting classifications of pathogenicity 1

p.Thr1182Ile Single submitter ⚠

Benign 1

p.Val807= Multiple submitters

Likely benign 5

p.Glu553del Single submitter
p.Gly840Ser Single submitter
p.Ile1164Val Single submitter
p.Ile491Met Single submitter
p.Lys473= Single submitter

Uncertain significance 128

p.Ala1009Thr Single submitter ⚠
p.Ala1075Val Single submitter ⚠
p.Ala1160Thr Single submitter ⚠
p.Ala1186Thr Single submitter ⚠
p.Ala709Val Single submitter ⚠
p.Ala725Ser Single submitter ⚠
p.Ala78Pro Single submitter ⚠
p.Ala846Pro Single submitter ⚠
p.Ala951Val Single submitter ⚠
p.Arg1007Gly Single submitter ⚠
p.Arg1059Gln Single submitter ⚠
p.Arg1059Gly Single submitter ⚠
p.Arg1134Ile Single submitter ⚠
p.Arg1210Gln Single submitter ⚠
p.Arg145Gly Single submitter ⚠
p.Arg309Met Single submitter ⚠
p.Arg445Lys Single submitter ⚠
p.Arg461Thr Single submitter ⚠
p.Arg638Gln Single submitter ⚠
p.Arg663Trp Single submitter ⚠
p.Arg664His Single submitter ⚠
p.Arg822Cys Single submitter ⚠
p.Arg822His Single submitter ⚠
p.Arg886Lys Single submitter ⚠
p.Arg890Gln Single submitter ⚠
p.Asn1142Lys Single submitter ⚠
p.Asn1197Lys Single submitter ⚠
p.Asn1226Ser Single submitter ⚠
p.Asn211Ser Single submitter ⚠
p.Asn464Asp Single submitter ⚠
p.Asn497Ser Single submitter ⚠
p.Asn561Ile Single submitter ⚠
p.Asn584fs Single submitter
p.Asn659Ser Single submitter ⚠
p.Asn880Ser Single submitter ⚠
p.Asp1258Asn Single submitter ⚠
p.Asp210Asn Single submitter ⚠
p.Asp272Glu Single submitter ⚠
p.Asp501Gly Single submitter ⚠
p.Asp539Glu Single submitter ⚠
p.Asp646Asn Single submitter ⚠
p.Asp785Gly Single submitter ⚠
p.Asp993Asn Single submitter ⚠
p.Cys201Tyr Single submitter ⚠
p.Cys417Arg Single submitter ⚠
p.Cys660Ser Single submitter ⚠
p.Cys828Ser Single submitter ⚠
p.Gln1082Pro Single submitter ⚠
p.Gln1189Arg Single submitter ⚠
p.Gln168His Single submitter ⚠
p.Gln585Lys Single submitter ⚠
p.Gln708Pro Single submitter ⚠
p.Gln917Arg Single submitter ⚠
p.Glu1056Gly Single submitter ⚠
p.Glu1064Val Single submitter ⚠
p.Glu116Ala Single submitter ⚠
p.Glu1231Lys Single submitter ⚠
p.Glu301Asp Single submitter ⚠
p.Glu403Asp Single submitter ⚠
p.Glu410Lys Single submitter ⚠
p.Glu451Gly Single submitter ⚠
p.Glu486Asp Single submitter ⚠
p.Glu521Asp Single submitter ⚠
p.Glu534Gln Single submitter ⚠
p.Glu555Lys Single submitter ⚠
p.Glu564Asp Single submitter ⚠
p.Glu735Lys Single submitter ⚠
p.Glu797Asp Single submitter ⚠
p.Glu950Asp Single submitter ⚠
p.Gly1124Arg Single submitter ⚠
p.Gly963Trp Single submitter ⚠
p.Ile169Thr Single submitter ⚠
p.Ile455Phe Single submitter ⚠
p.Ile455Val Single submitter ⚠
p.Ile491Leu Single submitter ⚠
p.Ile624Val Single submitter ⚠
p.Leu184Ser Single submitter ⚠
p.Leu665Ser Single submitter ⚠
p.Leu759Ser Single submitter ⚠
p.Leu83Val Single submitter ⚠
p.Lys1062Arg Single submitter ⚠
p.Lys1193Gln Single submitter ⚠
p.Lys1216Gln Single submitter ⚠
p.Lys291Asn Single submitter ⚠
p.Lys318Arg Single submitter
p.Lys37Arg Single submitter ⚠
p.Lys647Arg Single submitter ⚠
p.Lys835Arg Single submitter ⚠
p.Lys845Asn Single submitter ⚠
p.Met873Val Single submitter ⚠
p.Phe566Ser Single submitter ⚠
p.Pro1104Gln Single submitter ⚠
p.Pro467His Single submitter ⚠
p.Pro494Ala Single submitter ⚠
p.Pro59Ala Single submitter ⚠
p.Pro657Ser Single submitter ⚠
p.Pro674Thr Single submitter ⚠
p.Pro774Thr Single submitter ⚠
p.Pro779Ser Single submitter ⚠
p.Pro996Thr Single submitter ⚠
p.Ser1016Arg Single submitter ⚠
p.Ser1088Leu Single submitter ⚠
p.Ser1095Asn Single submitter ⚠
p.Ser1128Leu Single submitter ⚠
p.Ser1159Pro Single submitter ⚠
p.Ser1181Asn Single submitter ⚠
p.Ser1208Asn Single submitter ⚠
p.Ser158Pro Single submitter
p.Ser468Pro Single submitter ⚠
p.Ser513Tyr Single submitter ⚠
p.Ser656Cys Single submitter ⚠
p.Ser778Tyr Single submitter ⚠
p.Thr1036Ile Single submitter ⚠
p.Thr1114Ile Single submitter ⚠
p.Thr1188Met Single submitter ⚠
p.Thr234Pro Single submitter ⚠
p.Thr481Ile Single submitter ⚠
p.Thr531Met Single submitter ⚠
p.Thr793Ala Single submitter ⚠
p.Thr836Ser Single submitter ⚠
p.Thr892Pro Single submitter ⚠
p.Tyr9Cys Single submitter ⚠
p.Val1004Ala Single submitter ⚠
p.Val1140Gly Single submitter ⚠
p.Val1173Leu Single submitter ⚠
p.Val413Ala Single submitter ⚠
p.Val428Leu Single submitter ⚠
p.Val597Ile Single submitter ⚠