ARID5A — 99 ClinVar variants
All ClinVar germline ARID5A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
1 Conflicting · 6 Likely benign · 92 Uncertain significance
Full ARID5A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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ARID5A p.Pro432Leu
Conflicting
Single submitter
ARID5A-related disorder
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARID5A p.Ala127Val Uncertain significance Single submitter
- ARID5A p.Ala182Thr Uncertain significance Single submitter
- ARID5A p.Ala288Val Uncertain significance Single submitter
- ARID5A p.Ala329Val Uncertain significance Single submitter
- ARID5A p.Ala393Thr Uncertain significance Single submitter
- ARID5A p.Ala398Val Uncertain significance Single submitter
- ARID5A p.Ala476Val Uncertain significance Single submitter
- ARID5A p.Ala549Ser Uncertain significance Single submitter
- ARID5A p.Ala562Ser Uncertain significance Single submitter
- ARID5A p.Ala584Val Uncertain significance Single submitter
- ARID5A p.Arg108His Uncertain significance Single submitter
- ARID5A p.Arg170Trp Uncertain significance Single submitter
- ARID5A p.Arg241Trp Uncertain significance Single submitter
- ARID5A p.Arg281His Uncertain significance Single submitter
- ARID5A p.Arg395Cys Uncertain significance Single submitter
- ARID5A p.Arg395His Uncertain significance Single submitter
- ARID5A p.Arg395Ser Uncertain significance Single submitter
- ARID5A p.Arg445His Uncertain significance Single submitter
- ARID5A p.Arg460Trp Uncertain significance Single submitter
- ARID5A p.Arg564Cys Uncertain significance Single submitter
- ARID5A p.Arg564His Uncertain significance Single submitter
- ARID5A p.Asp151Val Uncertain significance Single submitter
- ARID5A p.Asp560Asn Uncertain significance Single submitter
- ARID5A p.Cys474Tyr Uncertain significance Single submitter
- ARID5A p.Gln209His Uncertain significance Single submitter
- ARID5A p.Gln274Lys Uncertain significance Single submitter
- ARID5A p.Glu14Lys Uncertain significance Single submitter
- ARID5A p.Glu177Lys Uncertain significance Single submitter
- ARID5A p.Glu350Lys Uncertain significance Single submitter
- ARID5A p.Glu448Lys Uncertain significance Single submitter
- ARID5A p.Glu54Asp Uncertain significance Single submitter
- ARID5A p.Gly174Glu Uncertain significance Single submitter
- ARID5A p.Gly220Ser Uncertain significance Single submitter
- ARID5A p.Gly234Ser Uncertain significance Single submitter
- ARID5A p.Gly283Glu Uncertain significance Single submitter
- ARID5A p.Gly342Ser Uncertain significance Single submitter
- ARID5A p.Gly482Ser Uncertain significance Single submitter
- ARID5A p.Gly489Ser Uncertain significance Single submitter
- ARID5A p.His347Gln Uncertain significance Single submitter
- ARID5A p.Ile254Val Uncertain significance Single submitter
- ARID5A p.Leu206Phe Uncertain significance Single submitter
- ARID5A p.Leu325Pro Uncertain significance Single submitter
- ARID5A p.Leu371Ile Uncertain significance Single submitter
- ARID5A p.Leu459Pro Uncertain significance Single submitter
- ARID5A p.Leu524Pro Uncertain significance Single submitter
- ARID5A p.Leu551Pro Uncertain significance Single submitter
- ARID5A p.Leu563Phe Uncertain significance Single submitter
- ARID5A p.Lys164Gln Uncertain significance Single submitter
- ARID5A p.Lys167Glu Uncertain significance Single submitter
- ARID5A p.Lys181Arg Uncertain significance Single submitter
- ARID5A p.Lys260Arg Uncertain significance Single submitter
- ARID5A p.Lys423Asn Uncertain significance Single submitter
- ARID5A p.Lys519Arg Uncertain significance Single submitter
- ARID5A p.Met421Thr Uncertain significance Single submitter
- ARID5A p.Met421Val Uncertain significance Single submitter
- ARID5A p.Met547Leu Uncertain significance Single submitter
- ARID5A p.Phe526Tyr Uncertain significance Single submitter
- ARID5A p.Pro179Leu Uncertain significance Single submitter
- ARID5A p.Pro211Ala Uncertain significance Single submitter
- ARID5A p.Pro24His Uncertain significance Single submitter
- ARID5A p.Pro290Thr Uncertain significance Single submitter
- ARID5A p.Pro298Leu Uncertain significance Single submitter
- ARID5A p.Pro375Arg Uncertain significance Single submitter
- ARID5A p.Pro375Leu Uncertain significance Single submitter
- ARID5A p.Pro396Ser Uncertain significance Single submitter
- ARID5A p.Pro429Leu Uncertain significance Single submitter
- ARID5A p.Pro429Ser Uncertain significance Single submitter
- ARID5A p.Pro515Ser Uncertain significance Single submitter
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ARID5A p.Pro532Leu
Uncertain significance
Single submitter
ARID5A-related disorder
- ARID5A p.Pro544Ser Uncertain significance Single submitter
- ARID5A p.Pro556Thr Uncertain significance Single submitter
- ARID5A p.Pro569Leu Uncertain significance Single submitter
- ARID5A p.Ser289Phe Uncertain significance Single submitter
- ARID5A p.Ser308Phe Uncertain significance Single submitter
- ARID5A p.Ser419Tyr Uncertain significance Single submitter
- ARID5A p.Ser443Arg Uncertain significance Single submitter
- ARID5A p.Ser545Leu Uncertain significance Single submitter
- ARID5A p.Thr349Ile Uncertain significance Single submitter
- ARID5A p.Thr430Met Uncertain significance Single submitter
- ARID5A p.Thr514Ile Uncertain significance Single submitter
- ARID5A p.Thr557Met Uncertain significance Single submitter
- ARID5A p.Thr580Ala Uncertain significance Single submitter
- ARID5A p.Val227Met Uncertain significance Single submitter
- ARID5A p.Val230Glu Uncertain significance Single submitter
- ARID5A p.Val388Gly Uncertain significance Single submitter
- ARID5A p.Val462Met Uncertain significance Single submitter
- ARID5A p.Val530Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ARID5A variants
Conflicting classifications of pathogenicity 1
- p.Pro432Leu Single submitter ARID5A-related disorder ⚠
Likely benign 6
- p.Ser455Gly Single submitter
- c.571-4C>A No assertion criteria ARID5A-related disorder
- p.Gly194Glu No assertion criteria ARID5A-related disorder
- p.Leu304Pro No assertion criteria ARID5A-related disorder
- p.Pro508= No assertion criteria ARID5A-related disorder
- p.Val484= No assertion criteria ARID5A-related disorder
Uncertain significance 92
- p.Ala127Val Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala288Val Single submitter ⚠
- p.Ala329Val Single submitter ⚠
- p.Ala393Thr Single submitter ⚠
- p.Ala398Val Single submitter ⚠
- p.Ala476Val Single submitter ⚠
- p.Ala549Ser Single submitter ⚠
- p.Ala562Ser Single submitter ⚠
- p.Ala584Val Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg170Trp Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg395Cys Single submitter ⚠
- p.Arg395His Single submitter ⚠
- p.Arg395Ser Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg460Trp Single submitter ⚠
- p.Arg564Cys Single submitter ⚠
- p.Arg564His Single submitter ⚠
- p.Asp151Val Single submitter ⚠
- p.Asp560Asn Single submitter ⚠
- p.Cys474Tyr Single submitter ⚠
- p.Gln209His Single submitter ⚠
- p.Gln274Lys Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu177Lys Single submitter ⚠
- p.Glu350Lys Single submitter ⚠
- p.Glu448Lys Single submitter ⚠
- p.Glu54Asp Single submitter ⚠
- p.Glu57Lys Single submitter
- p.Gly174Glu Single submitter ⚠
- p.Gly220Ser Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly283Glu Single submitter ⚠
- p.Gly342Ser Single submitter ⚠
- p.Gly482Ser Single submitter ⚠
- p.Gly489Ser Single submitter ⚠
- p.His347Gln Single submitter ⚠
- p.His81fs Single submitter
- p.Ile254Val Single submitter ⚠
- p.Leu206Phe Single submitter ⚠
- p.Leu325Pro Single submitter ⚠
- p.Leu371Ile Single submitter ⚠
- p.Leu459Pro Single submitter ⚠
- p.Leu524Pro Single submitter ⚠
- p.Leu551Pro Single submitter ⚠
- p.Leu563Phe Single submitter ⚠
- p.Lys164Gln Single submitter ⚠
- p.Lys167Glu Single submitter ⚠
- p.Lys181Arg Single submitter ⚠
- p.Lys260Arg Single submitter ⚠
- p.Lys423Asn Single submitter ⚠
- p.Lys519Arg Single submitter ⚠
- p.Met421Thr Single submitter ⚠
- p.Met421Val Single submitter ⚠
- p.Met547Leu Single submitter ⚠
- p.Phe526Tyr Single submitter ⚠
- p.Pro179Leu Single submitter ⚠
- p.Pro211Ala Single submitter ⚠
- p.Pro24His Single submitter ⚠
- p.Pro290Thr Single submitter ⚠
- p.Pro298Leu Single submitter ⚠
- p.Pro375Arg Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Pro396Ser Single submitter ⚠
- p.Pro429Leu Single submitter ⚠
- p.Pro429Ser Single submitter ⚠
- p.Pro515Ser Single submitter ⚠
- p.Pro532Gln Single submitter ⚠
- p.Pro532Leu Single submitter ARID5A-related disorder ⚠
- p.Pro544Ser Single submitter ⚠
- p.Pro556Thr Single submitter ⚠
- p.Pro569Leu Single submitter ⚠
- p.Ser268Asn Single submitter
- p.Ser289Phe Single submitter ⚠
- p.Ser308Phe Single submitter ⚠
- p.Ser419Tyr Single submitter ⚠
- p.Ser443Arg Single submitter ⚠
- p.Ser545Leu Single submitter ⚠
- p.Thr349Ile Single submitter ⚠
- p.Thr430Met Single submitter ⚠
- p.Thr514Ile Single submitter ⚠
- p.Thr557Met Single submitter ⚠
- p.Thr580Ala Single submitter ⚠
- p.Trp574Arg Single submitter ⚠
- p.Val227Met Single submitter ⚠
- p.Val230Glu Single submitter ⚠
- p.Val388Gly Single submitter ⚠
- p.Val462Met Single submitter ⚠
- p.Val530Leu Single submitter ⚠