ARK2C — 22 ClinVar variants
All ClinVar germline ARK2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Likely benign · 21 Uncertain significance
Full ARK2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARK2C p.Ala157Thr Uncertain significance Single submitter
- ARK2C p.Arg211Gln Uncertain significance Single submitter
- ARK2C p.Asn227Thr Uncertain significance Single submitter
- ARK2C p.Gln147His Uncertain significance Single submitter
- ARK2C p.Gln174Glu Uncertain significance Single submitter
- ARK2C p.Gln46Pro Uncertain significance Single submitter
- ARK2C p.His29Gln Uncertain significance Single submitter
- ARK2C p.Ile180Met Uncertain significance Single submitter
- ARK2C p.Pro84Ser Uncertain significance Single submitter
- ARK2C p.Ser165Thr Uncertain significance Single submitter
- ARK2C p.Ser65Thr Uncertain significance Single submitter
- ARK2C p.Ser75Arg Uncertain significance Single submitter
- ARK2C p.Val134Leu Uncertain significance Single submitter
- ARK2C p.Val207Ile Uncertain significance Single submitter
- ARK2C p.Val235Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ARK2C p.Arg138Cys Uncertain significance Single submitter
- ARK2C p.Arg236Gln Uncertain significance Single submitter
- ARK2C p.Asp345Asn Uncertain significance Single submitter
- ARK2C p.Gly278Cys Uncertain significance Single submitter
- ARK2C p.Leu114Met Uncertain significance Single submitter
- ARK2C p.Leu221Val Uncertain significance Single submitter
All ARK2C variants
Likely benign 1
- p.Leu9= Single submitter
Uncertain significance 21
- p.Ala157Thr Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg211Gln Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Asn227Thr Single submitter ⚠
- p.Asp345Asn Single submitter ⚠
- p.Gln147His Single submitter ⚠
- p.Gln174Glu Single submitter ⚠
- p.Gln46Pro Single submitter ⚠
- p.Gly278Cys Single submitter ⚠
- p.His29Gln Single submitter ⚠
- p.Ile180Met Single submitter ⚠
- p.Leu114Met Single submitter ⚠
- p.Leu221Val Single submitter ⚠
- p.Pro84Ser Single submitter ⚠
- p.Ser165Thr Single submitter ⚠
- p.Ser65Thr Single submitter ⚠
- p.Ser75Arg Single submitter ⚠
- p.Val134Leu Single submitter ⚠
- p.Val207Ile Single submitter ⚠
- p.Val235Ile Single submitter ⚠