ARL11 — 34 ClinVar variants
All ClinVar germline ARL11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Benign/Likely benign · 3 Likely benign · 30 Uncertain significance
Full ARL11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL11 p.Ala23Val Uncertain significance Single submitter
- ARL11 p.Arg138Gly Uncertain significance Single submitter
- ARL11 p.Arg176Cys Uncertain significance Single submitter
- ARL11 p.Asn111Asp Uncertain significance Single submitter
- ARL11 p.Asp192Gly Uncertain significance Single submitter
- ARL11 p.Glu39Asp Uncertain significance Single submitter
- ARL11 p.Gly24Ser Uncertain significance Single submitter
- ARL11 p.Leu32Arg Uncertain significance Single submitter
- ARL11 p.Lys134Thr Uncertain significance Single submitter
- ARL11 p.Lys194Arg Uncertain significance Single submitter
- ARL11 p.Met18Val Uncertain significance Single submitter
- ARL11 p.Pro69Leu Uncertain significance Single submitter
- ARL11 p.Pro69Ser Uncertain significance Single submitter
- ARL11 p.Ser168Asn Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ARL11 p.Ala100Val Likely benign Single submitter
- ARL11 p.Ala129Val Uncertain significance Single submitter
- ARL11 p.Ala68Asp Uncertain significance Single submitter
- ARL11 p.Ala68Thr Likely benign Single submitter
- ARL11 p.Arg190Cys Uncertain significance Single submitter
- ARL11 p.Arg95Cys Uncertain significance Single submitter
- ARL11 p.Arg95His Uncertain significance Single submitter
- ARL11 p.Leu157Phe Uncertain significance Single submitter
- ARL11 p.Leu84Phe Uncertain significance Single submitter
- ARL11 p.Met112Val Uncertain significance Single submitter
- ARL11 p.Pro110Thr Uncertain significance Single submitter
- ARL11 p.Ser99Leu Uncertain significance Single submitter
- ARL11 p.Tyr77Cys Uncertain significance Single submitter
- ARL11 p.Val115Ile Uncertain significance Single submitter
- ARL11 p.Val16Ala Uncertain significance Single submitter
- ARL11 p.Val16Met Uncertain significance Single submitter
- ARL11 p.Val4Glu Uncertain significance Single submitter
- ARL11 p.Val57Met Uncertain significance Single submitter
All ARL11 variants
Benign/Likely benign 1
- p.Trp149Ter Multiple submitters
Likely benign 3
- p.Ala100Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Pro42= Single submitter
Uncertain significance 30
- p.Ala129Val Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala68Asp Single submitter ⚠
- p.Arg138Gly Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg190Cys Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn111Asp Single submitter ⚠
- p.Asp192Gly Single submitter ⚠
- p.Glu39Asp Single submitter ⚠
- p.Gly24Ser Single submitter ⚠
- p.Leu157Phe Single submitter ⚠
- p.Leu32Arg Single submitter ⚠
- p.Leu84Phe Single submitter ⚠
- p.Lys134Thr Single submitter ⚠
- p.Lys194Arg Single submitter ⚠
- p.Met112Val Single submitter ⚠
- p.Met18Val Single submitter ⚠
- p.Pro110Thr Single submitter ⚠
- p.Pro69Leu Single submitter ⚠
- p.Pro69Ser Single submitter ⚠
- p.Ser168Asn Single submitter ⚠
- p.Ser99Leu Single submitter ⚠
- p.Tyr77Cys Single submitter ⚠
- p.Val115Ile Single submitter ⚠
- p.Val16Ala Single submitter ⚠
- p.Val16Met Single submitter ⚠
- p.Val4Glu Single submitter ⚠
- p.Val57Met Single submitter ⚠