ARL14 — 32 ClinVar variants
All ClinVar germline ARL14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
3 Likely benign · 29 Uncertain significance
Full ARL14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL14 p.Arg149Gly Uncertain significance Single submitter
- ARL14 p.Arg56Ser Uncertain significance Single submitter
- ARL14 p.Asn115Lys Uncertain significance Single submitter
- ARL14 p.Glu53Lys Uncertain significance Single submitter
- ARL14 p.Gly161Glu Uncertain significance Single submitter
- ARL14 p.Gly67Glu Uncertain significance Single submitter
- ARL14 p.Ile113Val Uncertain significance Single submitter
- ARL14 p.Ile45Val Uncertain significance Single submitter
- ARL14 p.Leu18Arg Uncertain significance Single submitter
- ARL14 p.Met179Ile Uncertain significance Single submitter
- ARL14 p.Met179Val Uncertain significance Single submitter
- ARL14 p.Phe47Leu Uncertain significance Single submitter
- ARL14 p.Pro43Ser Uncertain significance Single submitter
- ARL14 p.Thr137Ser Uncertain significance Single submitter
- ARL14 p.Thr44Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- ARL14 p.Ala158Val Uncertain significance Single submitter
- ARL14 p.Arg149Trp Uncertain significance Single submitter
- ARL14 p.Asp83Glu Uncertain significance Single submitter
- ARL14 p.Asp93Glu Uncertain significance Single submitter
- ARL14 p.Glu162Gly Uncertain significance Single submitter
- ARL14 p.Glu162Lys Uncertain significance Single submitter
- ARL14 p.Gly167Val Uncertain significance Single submitter
- ARL14 p.Ile42Asn Uncertain significance Single submitter
- ARL14 p.Leu145Ile Uncertain significance Single submitter
- ARL14 p.Leu186Trp Uncertain significance Single submitter
- ARL14 p.Leu35Phe Uncertain significance Single submitter
- ARL14 p.Pro128Ser Uncertain significance Single submitter
- ARL14 p.Thr132Ile Uncertain significance Single submitter
- ARL14 p.Tyr31Phe Uncertain significance Single submitter
All ARL14 variants
Likely benign 3
- p.Ser177= Single submitter
- p.Ser3Leu Single submitter
- p.Thr11Ala Single submitter
Uncertain significance 29
- p.Ala158Val Single submitter ⚠
- p.Arg149Gly Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg56Ser Single submitter ⚠
- p.Asn115Lys Single submitter ⚠
- p.Asp83Glu Single submitter ⚠
- p.Asp93Glu Single submitter ⚠
- p.Glu162Gly Single submitter ⚠
- p.Glu162Lys Single submitter ⚠
- p.Glu53Lys Single submitter ⚠
- p.Gly161Glu Single submitter ⚠
- p.Gly167Val Single submitter ⚠
- p.Gly67Glu Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile42Asn Single submitter ⚠
- p.Ile45Val Single submitter ⚠
- p.Leu145Ile Single submitter ⚠
- p.Leu186Trp Single submitter ⚠
- p.Leu18Arg Single submitter ⚠
- p.Leu35Phe Single submitter ⚠
- p.Met179Ile Single submitter ⚠
- p.Met179Val Single submitter ⚠
- p.Phe47Leu Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro43Ser Single submitter ⚠
- p.Thr132Ile Single submitter ⚠
- p.Thr137Ser Single submitter ⚠
- p.Thr44Ile Single submitter ⚠
- p.Tyr31Phe Single submitter ⚠