ARL16 — 37 ClinVar variants
All ClinVar germline ARL16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Likely pathogenic · 1 Likely benign · 35 Uncertain significance
Full ARL16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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ARL16 c.-41G>T
Likely pathogenic
Single submitter
childhood-onset schizophrenia
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL16 c.-20C>A Uncertain significance Single submitter
- ARL16 c.-3G>A Uncertain significance Single submitter
- ARL16 p.Ala7Pro Uncertain significance Single submitter
- ARL16 p.Arg57Trp Uncertain significance Single submitter
- ARL16 p.Arg75Leu Uncertain significance Single submitter
- ARL16 p.Arg75Pro Uncertain significance Single submitter
- ARL16 p.Asp47Tyr Uncertain significance Single submitter
- ARL16 p.Gln20Glu Uncertain significance Single submitter
- ARL16 p.Glu58Val Uncertain significance Single submitter
- ARL16 p.Gly42Val Uncertain significance Single submitter
- ARL16 p.Gly9Asp Uncertain significance Single submitter
- ARL16 p.Leu100Phe Uncertain significance Single submitter
- ARL16 p.Leu3Phe Uncertain significance Single submitter
- ARL16 p.Leu3Pro Uncertain significance Single submitter
- ARL16 p.Leu45Arg Uncertain significance Single submitter
- ARL16 p.Lys12Arg Uncertain significance Single submitter
- ARL16 p.Met123Thr Uncertain significance Single submitter
- ARL16 p.Met81Val Uncertain significance Single submitter
- ARL16 p.Phe114Leu Uncertain significance Single submitter
- ARL16 p.Ser69Asn Uncertain significance Single submitter
- ARL16 p.Ser84Tyr Uncertain significance Single submitter
- ARL16 p.Thr13Met Uncertain significance Single submitter
- ARL16 p.Thr46Ala Uncertain significance Single submitter
- ARL16 p.Thr46Ile Uncertain significance Single submitter
- ARL16 p.Trp67Cys Uncertain significance Single submitter
- ARL16 p.Trp67Ser Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ARL16 p.Ala108Gly Uncertain significance Single submitter
- ARL16 p.Ala152Thr Uncertain significance Single submitter
- ARL16 p.Ala167Val Uncertain significance Single submitter
- ARL16 p.Arg153Cys Uncertain significance Single submitter
- ARL16 p.Pro34Gln Uncertain significance Single submitter
- ARL16 p.Ser76Phe Uncertain significance Single submitter
- ARL16 p.Thr146Ile Uncertain significance Single submitter
- ARL16 p.Tyr71Cys Uncertain significance Single submitter
- ARL16 p.Val10Ala Uncertain significance Single submitter
All ARL16 variants
Likely benign 1
- p.Thr125Met Single submitter
Uncertain significance 35
- c.-20C>A Single submitter ⚠
- c.-3G>A Single submitter ⚠
- p.Ala108Gly Single submitter ⚠
- p.Ala152Thr Single submitter ⚠
- p.Ala167Val Single submitter ⚠
- p.Ala7Pro Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg57Trp Single submitter ⚠
- p.Arg75Leu Single submitter ⚠
- p.Arg75Pro Single submitter ⚠
- p.Asp47Tyr Single submitter ⚠
- p.Gln20Glu Single submitter ⚠
- p.Glu58Val Single submitter ⚠
- p.Gly42Val Single submitter ⚠
- p.Gly9Asp Single submitter ⚠
- p.Leu100Phe Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Leu3Pro Single submitter ⚠
- p.Leu45Arg Single submitter ⚠
- p.Lys12Arg Single submitter ⚠
- p.Met123Thr Single submitter ⚠
- p.Met81Val Single submitter ⚠
- p.Phe114Leu Single submitter ⚠
- p.Pro34Gln Single submitter ⚠
- p.Ser69Asn Single submitter ⚠
- p.Ser76Phe Single submitter ⚠
- p.Ser84Tyr Single submitter ⚠
- p.Thr13Met Single submitter ⚠
- p.Thr146Ile Single submitter ⚠
- p.Thr46Ala Single submitter ⚠
- p.Thr46Ile Single submitter ⚠
- p.Trp67Cys Single submitter ⚠
- p.Trp67Ser Single submitter ⚠
- p.Tyr71Cys Single submitter ⚠
- p.Val10Ala Single submitter ⚠