ARL4A — 19 ClinVar variants
All ClinVar germline ARL4A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
19 Uncertain significance
Full ARL4A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL4A p.Arg39Ser Uncertain significance Single submitter
- ARL4A p.Asp7Glu Uncertain significance Single submitter
- ARL4A p.Gln19Arg Uncertain significance Single submitter
- ARL4A p.Glu180Gln Uncertain significance Single submitter
- ARL4A p.Ile11Val Uncertain significance Single submitter
- ARL4A p.Ile131Val Uncertain significance Single submitter
- ARL4A p.Ile170Val Uncertain significance Single submitter
- ARL4A p.Ile187Thr Uncertain significance Single submitter
- ARL4A p.Met192Thr Uncertain significance Single submitter
- ARL4A p.Ser13Cys Uncertain significance Single submitter
- ARL4A p.Ser145Pro Uncertain significance Single submitter
- ARL4A p.Thr113Ser Uncertain significance Single submitter
- ARL4A p.Val46Ile Uncertain significance Single submitter
- ARL4A p.Val49Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARL4A variants
Uncertain significance 19
- p.Arg39Ser Single submitter ⚠
- p.Asp29Ala Single submitter ⚠
- p.Asp7Glu Single submitter ⚠
- p.Cys30Gly Single submitter
- p.Gln19Arg Single submitter ⚠
- p.Glu180Gln Single submitter ⚠
- p.His183Gln Single submitter
- p.Ile11Val Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile170Val Single submitter ⚠
- p.Ile187Thr Single submitter ⚠
- p.Leu138Phe Single submitter ⚠
- p.Met192Thr Single submitter ⚠
- p.Ser13Cys Single submitter ⚠
- p.Ser145Pro Single submitter ⚠
- p.Ser20Cys Single submitter ⚠
- p.Thr113Ser Single submitter ⚠
- p.Val46Ile Single submitter ⚠
- p.Val49Ile Single submitter ⚠