ARL4C — 12 ClinVar variants
All ClinVar germline ARL4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Benign · 11 Uncertain significance
Full ARL4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL4C p.Arg183Gly Uncertain significance Single submitter
- ARL4C p.Glu177Asp Uncertain significance Single submitter
- ARL4C p.Ile150Thr Uncertain significance Single submitter
- ARL4C p.Leu54Pro Uncertain significance Single submitter
- ARL4C p.Lys113Arg Uncertain significance Single submitter
- ARL4C p.Phe38Leu Uncertain significance Single submitter
- ARL4C p.Val124Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All ARL4C variants
Benign 1
- c.575+8G>T Single submitter
Uncertain significance 11
- p.Arg183Gly Single submitter ⚠
- p.Glu177Asp Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Leu54Pro Single submitter ⚠
- p.Lys113Arg Single submitter ⚠
- p.Lys53Arg Single submitter ⚠
- p.Lys53Asn Single submitter ⚠
- p.Lys53Gln Single submitter ⚠
- p.Phe38Leu Single submitter ⚠
- p.Thr58Met Single submitter ⚠
- p.Val124Ile Single submitter ⚠