ARL4D — 27 ClinVar variants
All ClinVar germline ARL4D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
2 Likely benign · 25 Uncertain significance
Full ARL4D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL4D p.Ala104Val Uncertain significance Single submitter
- ARL4D p.Ala12Gly Uncertain significance Single submitter
- ARL4D p.Ala160Thr Uncertain significance Single submitter
- ARL4D p.Ala21Thr Uncertain significance Single submitter
- ARL4D p.Ala9Val Uncertain significance Single submitter
- ARL4D p.Arg155Gln Uncertain significance Single submitter
- ARL4D p.Arg155Pro Uncertain significance Single submitter
- ARL4D p.Arg40Ser Uncertain significance Single submitter
- ARL4D p.Arg61Gln Uncertain significance Single submitter
- ARL4D p.Arg68His Uncertain significance Single submitter
- ARL4D p.Arg84Pro Uncertain significance Single submitter
- ARL4D p.Gln48Glu Uncertain significance Single submitter
- ARL4D p.Gly96Ser Uncertain significance Single submitter
- ARL4D p.His18Asn Uncertain significance Single submitter
- ARL4D p.Leu162Phe Uncertain significance Single submitter
- ARL4D p.Lys44Asn Uncertain significance Single submitter
- ARL4D p.Ser49Gly Uncertain significance Single submitter
- ARL4D p.Thr163Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARL4D variants
Likely benign 2
- p.Ser13Ala Single submitter
- p.His117Arg No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 25
- p.Ala104Val Single submitter ⚠
- p.Ala12Gly Single submitter ⚠
- p.Ala160Thr Single submitter ⚠
- p.Ala21Thr Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg155Pro Single submitter ⚠
- p.Arg40Ser Single submitter ⚠
- p.Arg61Gln Single submitter ⚠
- p.Arg68His Single submitter ⚠
- p.Arg84Pro Single submitter ⚠
- p.Arg88His Single submitter
- p.Gln48Glu Single submitter ⚠
- p.Gly96Ser Single submitter ⚠
- p.His18Asn Single submitter ⚠
- p.Leu162Phe Single submitter ⚠
- p.Leu38Val Single submitter ⚠
- p.Leu64Phe Single submitter ⚠
- p.Lys113Glu Single submitter
- p.Lys44Asn Single submitter ⚠
- p.Phe46Leu Single submitter ⚠
- p.Ser31Phe Single submitter
- p.Ser49Gly Single submitter ⚠
- p.Thr163Ile Single submitter ⚠
- p.Val128Met Single submitter