ARL5B — 7 ClinVar variants
All ClinVar germline ARL5B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
7 Uncertain significance
Full ARL5B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL5B p.Ala136Thr Uncertain significance Single submitter
- ARL5B p.Arg175Gln Uncertain significance Single submitter
- ARL5B p.Gly68Ser Uncertain significance Single submitter
- ARL5B p.Met129Leu Uncertain significance Single submitter
- ARL5B p.Ser139Trp Uncertain significance Single submitter
- ARL5B p.Ser76Ala Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All ARL5B variants
Uncertain significance 7
- p.Ala136Thr Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Asn14Tyr Single submitter ⚠
- p.Gly68Ser Single submitter ⚠
- p.Met129Leu Single submitter ⚠
- p.Ser139Trp Single submitter ⚠
- p.Ser76Ala Single submitter ⚠