ARL5C — 28 ClinVar variants
All ClinVar germline ARL5C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
3 Likely benign · 25 Uncertain significance
Full ARL5C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL5C p.Ala167Thr Uncertain significance Single submitter
- ARL5C p.Arg103Gln Uncertain significance Single submitter
- ARL5C p.Arg98Gln Uncertain significance Single submitter
- ARL5C p.Glu163Lys Uncertain significance Single submitter
- ARL5C p.Glu40Asp Uncertain significance Single submitter
- ARL5C p.Glu54Asp Uncertain significance Single submitter
- ARL5C p.Gly156Asp Uncertain significance Single submitter
- ARL5C p.Ile11Asn Uncertain significance Single submitter
- ARL5C p.Ile154Met Uncertain significance Single submitter
- ARL5C p.Leu100Pro Uncertain significance Single submitter
- ARL5C p.Lys130Arg Uncertain significance Single submitter
- ARL5C p.Phe141Leu Uncertain significance Single submitter
- ARL5C p.Ser145Asn Uncertain significance Single submitter
- ARL5C p.Ser151Leu Uncertain significance Single submitter
- ARL5C p.Ser74Thr Uncertain significance Single submitter
- ARL5C p.Ser82Thr Uncertain significance Single submitter
- ARL5C p.Thr79Ile Uncertain significance Single submitter
- ARL5C p.Tyr34His Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ARL5C p.Ala159Val Uncertain significance Single submitter
- ARL5C p.Arg96Gln Uncertain significance Single submitter
- ARL5C p.Arg96Trp Uncertain significance Single submitter
- ARL5C p.Arg98Trp Likely benign Single submitter
- ARL5C p.Asp92Gly Uncertain significance Single submitter
- ARL5C p.Glu16Gly Uncertain significance Single submitter
- ARL5C p.Met133Thr Uncertain significance Single submitter
All ARL5C variants
Likely benign 3
- p.Arg35Gln Single submitter
- p.Arg98Trp Single submitter ⚠
- p.Thr94Met Single submitter
Uncertain significance 25
- p.Ala159Val Single submitter ⚠
- p.Ala167Thr Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Asp92Gly Single submitter ⚠
- p.Glu163Lys Single submitter ⚠
- p.Glu16Gly Single submitter ⚠
- p.Glu40Asp Single submitter ⚠
- p.Glu54Asp Single submitter ⚠
- p.Gly156Asp Single submitter ⚠
- p.Ile11Asn Single submitter ⚠
- p.Ile154Met Single submitter ⚠
- p.Ile154Thr Single submitter
- p.Leu100Pro Single submitter ⚠
- p.Lys130Arg Single submitter ⚠
- p.Met133Thr Single submitter ⚠
- p.Phe141Leu Single submitter ⚠
- p.Ser145Asn Single submitter ⚠
- p.Ser151Leu Single submitter ⚠
- p.Ser74Thr Single submitter ⚠
- p.Ser82Thr Single submitter ⚠
- p.Thr79Ile Single submitter ⚠
- p.Tyr34His Single submitter ⚠