ARL6IP4 — 89 ClinVar variants
All ClinVar germline ARL6IP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
4 Likely benign · 85 Uncertain significance
Full ARL6IP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL6IP4 c.103G>T Uncertain significance Single submitter
- ARL6IP4 c.136A>G Uncertain significance Single submitter
- ARL6IP4 c.164G>A Uncertain significance Single submitter
- ARL6IP4 c.167C>G Uncertain significance Single submitter
- ARL6IP4 c.191G>C Uncertain significance Single submitter
- ARL6IP4 c.203C>G Uncertain significance Single submitter
- ARL6IP4 c.205C>G Uncertain significance Single submitter
- ARL6IP4 c.260G>A Uncertain significance Single submitter
- ARL6IP4 c.265G>A Uncertain significance Single submitter
- ARL6IP4 c.287C>T Uncertain significance Single submitter
- ARL6IP4 c.292G>C Uncertain significance Single submitter
- ARL6IP4 c.41G>A Uncertain significance Single submitter
- ARL6IP4 c.56T>C Uncertain significance Single submitter
- ARL6IP4 c.58C>T Uncertain significance Single submitter
- ARL6IP4 c.80T>C Uncertain significance Single submitter
- ARL6IP4 c.92G>T Uncertain significance Single submitter
- ARL6IP4 c.-20G>A Uncertain significance Single submitter
- ARL6IP4 c.-32C>G Uncertain significance Single submitter
- ARL6IP4 c.-35T>C Uncertain significance Single submitter
- ARL6IP4 c.-39G>A Uncertain significance Single submitter
- ARL6IP4 c.-39G>C Uncertain significance Single submitter
- ARL6IP4 c.-3G>A Uncertain significance Single submitter
- ARL6IP4 c.-41G>A Uncertain significance Single submitter
- ARL6IP4 c.-44G>A Uncertain significance Single submitter
- ARL6IP4 c.-54G>A Uncertain significance Single submitter
- ARL6IP4 c.-75T>G Uncertain significance Single submitter
- ARL6IP4 p.Ala228Gly Uncertain significance Single submitter
- ARL6IP4 p.Ala228Val Uncertain significance Single submitter
- ARL6IP4 p.Ala38Thr Uncertain significance Single submitter
- ARL6IP4 p.Ala46Gly Uncertain significance Single submitter
- ARL6IP4 p.Ala49Val Uncertain significance Single submitter
- ARL6IP4 p.Ala68Thr Uncertain significance Single submitter
- ARL6IP4 p.Arg101Trp Uncertain significance Single submitter
- ARL6IP4 p.Arg147Gln Uncertain significance Single submitter
- ARL6IP4 p.Arg147Gly Uncertain significance Single submitter
- ARL6IP4 p.Arg185Cys Uncertain significance Single submitter
- ARL6IP4 p.Arg194His Uncertain significance Single submitter
- ARL6IP4 p.Arg19Gln Uncertain significance Single submitter
- ARL6IP4 p.Arg34Lys Uncertain significance Single submitter
- ARL6IP4 p.Arg69Gln Uncertain significance Single submitter
- ARL6IP4 p.Asp31Asn Uncertain significance Single submitter
- ARL6IP4 p.Gly125Ala Uncertain significance Single submitter
- ARL6IP4 p.Gly125Ser Uncertain significance Single submitter
- ARL6IP4 p.Leu121Met Uncertain significance Single submitter
- ARL6IP4 p.Lys27Arg Uncertain significance Single submitter
- ARL6IP4 p.Pro56Leu Uncertain significance Single submitter
- ARL6IP4 p.Pro58Arg Uncertain significance Single submitter
- ARL6IP4 p.Ser21Thr Uncertain significance Single submitter
- ARL6IP4 p.Ser41Tyr Uncertain significance Single submitter
- ARL6IP4 p.Ser91Leu Uncertain significance Single submitter
- ARL6IP4 p.Ser92Phe Uncertain significance Single submitter
- ARL6IP4 p.Thr72Arg Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ARL6IP4 p.Gln167His Uncertain significance Single submitter
- ARL6IP4 p.Glu22Ala Uncertain significance Single submitter
- ARL6IP4 p.Glu22Val Uncertain significance Single submitter
- ARL6IP4 p.Gly18Arg Uncertain significance Single submitter
- ARL6IP4 p.His146Asp Uncertain significance Single submitter
- ARL6IP4 p.Leu142Pro Uncertain significance Single submitter
- ARL6IP4 p.Thr210Ile Uncertain significance Single submitter
- ARL6IP4 p.Val4Phe Uncertain significance Single submitter
All ARL6IP4 variants
Likely benign 4
- c.-74C>T Single submitter
- p.Ile183Val Single submitter
- p.Lys113Arg Single submitter
- p.Pro50Ser Single submitter
Uncertain significance 85
- c.103G>T Single submitter ⚠
- c.136A>G Single submitter ⚠
- c.164G>A Single submitter ⚠
- c.167C>G Single submitter ⚠
- c.191G>C Single submitter ⚠
- c.203C>G Single submitter ⚠
- c.205C>G Single submitter ⚠
- c.210C>G Single submitter
- c.220G>A Single submitter
- c.260G>A Single submitter ⚠
- c.265G>A Single submitter ⚠
- c.284G>A Single submitter
- c.287C>T Single submitter ⚠
- c.292G>C Single submitter ⚠
- c.41G>A Single submitter ⚠
- c.56T>C Single submitter ⚠
- c.58C>T Single submitter ⚠
- c.74C>T Single submitter
- c.80T>C Single submitter ⚠
- c.92G>T Single submitter ⚠
- c.-20G>A Single submitter ⚠
- c.-30_-29del Single submitter
- c.-32C>G Single submitter ⚠
- c.-35T>C Single submitter ⚠
- c.-39G>A Single submitter ⚠
- c.-39G>C Single submitter ⚠
- c.-3G>A Single submitter ⚠
- c.-41G>A Single submitter ⚠
- c.-44G>A Single submitter ⚠
- c.-54G>A Single submitter ⚠
- c.-75T>G Single submitter ⚠
- p.Ala179Thr Single submitter
- p.Ala228Gly Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala38Thr Single submitter ⚠
- p.Ala46Gly Single submitter ⚠
- p.Ala49Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Arg101Trp Single submitter ⚠
- p.Arg147Gln Single submitter ⚠
- p.Arg147Gly Single submitter ⚠
- p.Arg165Gln Single submitter
- p.Arg180Gln Single submitter
- p.Arg180Trp Single submitter
- p.Arg185Cys Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg19Gln Single submitter ⚠
- p.Arg213Gly Single submitter
- p.Arg223Gly Single submitter
- p.Arg34Lys Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Asp160Tyr Single submitter
- p.Asp31Asn Single submitter ⚠
- p.Gln167His Single submitter ⚠
- p.Glu191Ala Single submitter
- p.Glu216Asp Single submitter
- p.Glu22Ala Single submitter ⚠
- p.Glu22Val Single submitter ⚠
- p.Gly125Ala Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.His146Asp Single submitter ⚠
- p.His214Gln Single submitter
- p.Ile217Leu Single submitter
- p.Leu121Met Single submitter ⚠
- p.Leu142Pro Single submitter ⚠
- p.Lys108Thr Single submitter
- p.Lys128Asn Single submitter
- p.Lys27Arg Single submitter ⚠
- p.Met172Thr Single submitter
- p.Pro56Leu Single submitter ⚠
- p.Pro58Arg Single submitter ⚠
- p.Ser10Leu Single submitter
- p.Ser21Thr Single submitter ⚠
- p.Ser41Tyr Single submitter ⚠
- p.Ser84Phe Single submitter
- p.Ser88Phe Single submitter
- p.Ser90Phe Single submitter
- p.Ser91Leu Single submitter ⚠
- p.Ser92Phe Single submitter ⚠
- p.Thr195Ala Single submitter
- p.Thr210Ile Single submitter ⚠
- p.Thr72Arg Single submitter ⚠
- p.Val209Ile Single submitter
- p.Val4Phe Single submitter ⚠