ARL6IP5 — 30 ClinVar variants
All ClinVar germline ARL6IP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
2 Likely benign · 28 Uncertain significance
Full ARL6IP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARL6IP5 p.Ala84Thr Uncertain significance Single submitter
- ARL6IP5 p.Arg91His Uncertain significance Single submitter
- ARL6IP5 p.Arg92Trp Uncertain significance Single submitter
- ARL6IP5 p.Arg96Cys Uncertain significance Single submitter
- ARL6IP5 p.Asn146Lys Uncertain significance Single submitter
- ARL6IP5 p.Asn86Ser Uncertain significance Single submitter
- ARL6IP5 p.Gly125Asp Uncertain significance Single submitter
- ARL6IP5 p.Gly69Glu Uncertain significance Single submitter
- ARL6IP5 p.Gly79Ala Uncertain significance Single submitter
- ARL6IP5 p.Ile176Met Uncertain significance Single submitter
- ARL6IP5 p.Ile71Leu Uncertain significance Single submitter
- ARL6IP5 p.Lys95Arg Uncertain significance Single submitter
- ARL6IP5 p.Pro7Gln Uncertain significance Single submitter
- ARL6IP5 p.Ser138Trp Uncertain significance Single submitter
- ARL6IP5 p.Ser184Gly Uncertain significance Single submitter
- ARL6IP5 p.Thr99Met Uncertain significance Single submitter
- ARL6IP5 p.Tyr182Cys Uncertain significance Single submitter
- ARL6IP5 p.Val102Ile Uncertain significance Single submitter
- ARL6IP5 p.Val104Met Uncertain significance Single submitter
- ARL6IP5 p.Val186Met Uncertain significance Single submitter
- ARL6IP5 p.Val3Ile Uncertain significance Single submitter
- ARL6IP5 p.Val76Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ARL6IP5 p.Asn143Asp Uncertain significance Single submitter
- ARL6IP5 p.Ile155Lys Uncertain significance Single submitter
- ARL6IP5 p.Leu169Gln Uncertain significance Single submitter
- ARL6IP5 p.Lys145Thr Uncertain significance Single submitter
- ARL6IP5 p.Met120Ile Uncertain significance Single submitter
- ARL6IP5 p.Phe134Ser Uncertain significance Single submitter
All ARL6IP5 variants
Likely benign 2
- p.Asn177Ser Single submitter
- p.Val89Ile Single submitter
Uncertain significance 28
- p.Ala84Thr Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Asn143Asp Single submitter ⚠
- p.Asn146Lys Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Gly125Asp Single submitter ⚠
- p.Gly69Glu Single submitter ⚠
- p.Gly79Ala Single submitter ⚠
- p.Ile155Lys Single submitter ⚠
- p.Ile176Met Single submitter ⚠
- p.Ile71Leu Single submitter ⚠
- p.Leu169Gln Single submitter ⚠
- p.Lys145Thr Single submitter ⚠
- p.Lys95Arg Single submitter ⚠
- p.Met120Ile Single submitter ⚠
- p.Phe134Ser Single submitter ⚠
- p.Pro7Gln Single submitter ⚠
- p.Ser138Trp Single submitter ⚠
- p.Ser184Gly Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Tyr182Cys Single submitter ⚠
- p.Val102Ile Single submitter ⚠
- p.Val104Met Single submitter ⚠
- p.Val186Met Single submitter ⚠
- p.Val3Ile Single submitter ⚠
- p.Val76Met Single submitter ⚠