ARL8B — 7 ClinVar variants
All ClinVar germline ARL8B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
7 Uncertain significance
Full ARL8B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All ARL8B variants
Uncertain significance 7
- p.Ala137Thr Single submitter
- p.Arg184Ile Single submitter ⚠
- p.Asn109Ser Single submitter ⚠
- p.Ile92Val Single submitter ⚠
- p.Leu25Ile Single submitter ⚠
- p.Met49Thr Single submitter
- p.Ser46Asn Single submitter ⚠