ARMC1 — 33 ClinVar variants
All ClinVar germline ARMC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Likely benign · 32 Uncertain significance
Full ARMC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC1 p.Ala25Val Uncertain significance Single submitter
- ARMC1 p.Ala266Pro Uncertain significance Single submitter
- ARMC1 p.Ala273Thr Uncertain significance Single submitter
- ARMC1 p.Arg127His Uncertain significance Single submitter
- ARMC1 p.Arg22Trp Uncertain significance Single submitter
- ARMC1 p.Arg257Gln Uncertain significance Single submitter
- ARMC1 p.Arg70Cys Uncertain significance Single submitter
- ARMC1 p.Gln132Glu Uncertain significance Single submitter
- ARMC1 p.Glu123Lys Uncertain significance Single submitter
- ARMC1 p.Ile45Val Uncertain significance Single submitter
- ARMC1 p.Ile90Thr Uncertain significance Single submitter
- ARMC1 p.Met115Thr Uncertain significance Single submitter
- ARMC1 p.Met124Arg Uncertain significance Single submitter
- ARMC1 p.Met124Ile Uncertain significance Single submitter
- ARMC1 p.Met76Leu Uncertain significance Single submitter
- ARMC1 p.Met8Ile Uncertain significance Single submitter
- ARMC1 p.Ser16Leu Uncertain significance Single submitter
- ARMC1 p.Ser4Phe Uncertain significance Single submitter
- ARMC1 p.Ser9Gly Uncertain significance Single submitter
- ARMC1 p.Thr155Met Uncertain significance Single submitter
- ARMC1 p.Tyr107His Uncertain significance Single submitter
- ARMC1 p.Val229Met Uncertain significance Single submitter
- ARMC1 p.Val258Leu Uncertain significance Single submitter
- ARMC1 p.Val56Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ARMC1 p.Ala26Val Uncertain significance Single submitter
- ARMC1 p.Arg127Cys Uncertain significance Single submitter
- ARMC1 p.Arg141Ser Uncertain significance Single submitter
- ARMC1 p.Asp27Glu Uncertain significance Single submitter
- ARMC1 p.Glu105Val Uncertain significance Single submitter
- ARMC1 p.Gly259Asp Uncertain significance Single submitter
- ARMC1 p.Val35Gly Uncertain significance Single submitter
- ARMC1 p.Val35Ile Uncertain significance Single submitter
All ARMC1 variants
Likely benign 1
- p.Ser4= Single submitter
Uncertain significance 32
- p.Ala25Val Single submitter ⚠
- p.Ala266Pro Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Arg127Cys Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg141Ser Single submitter ⚠
- p.Arg22Trp Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg70Cys Single submitter ⚠
- p.Asp27Glu Single submitter ⚠
- p.Gln132Glu Single submitter ⚠
- p.Glu105Val Single submitter ⚠
- p.Glu123Lys Single submitter ⚠
- p.Gly259Asp Single submitter ⚠
- p.Ile45Val Single submitter ⚠
- p.Ile90Thr Single submitter ⚠
- p.Met115Thr Single submitter ⚠
- p.Met124Arg Single submitter ⚠
- p.Met124Ile Single submitter ⚠
- p.Met76Leu Single submitter ⚠
- p.Met8Ile Single submitter ⚠
- p.Ser16Leu Single submitter ⚠
- p.Ser4Phe Single submitter ⚠
- p.Ser9Gly Single submitter ⚠
- p.Thr155Met Single submitter ⚠
- p.Tyr107His Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val258Leu Single submitter ⚠
- p.Val35Gly Single submitter ⚠
- p.Val35Ile Single submitter ⚠
- p.Val56Ile Single submitter ⚠