ARMC12 — 61 ClinVar variants
All ClinVar germline ARMC12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
3 Pathogenic · 1 Likely benign · 57 Uncertain significance
Full ARMC12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
ARMC12 p.Arg211Gln
Pathogenic
No assertion criteria
spermatogenic failure 90
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC12 p.Ala27Val Uncertain significance Single submitter
- ARMC12 p.Ala37Ser Uncertain significance Single submitter
- ARMC12 p.Ala85Asp Uncertain significance Single submitter
- ARMC12 p.Arg15Pro Uncertain significance Single submitter
- ARMC12 p.Arg62Gln Uncertain significance Single submitter
- ARMC12 p.Arg65Gln Uncertain significance Single submitter
- ARMC12 p.Asn263Lys Uncertain significance Single submitter
- ARMC12 p.Asn75Ser Uncertain significance Single submitter
- ARMC12 p.Gln186Arg Uncertain significance Single submitter
- ARMC12 p.Glu340Val Uncertain significance Single submitter
- ARMC12 p.Gly116Ser Uncertain significance Single submitter
- ARMC12 p.His184Tyr Uncertain significance Single submitter
- ARMC12 p.Ile313Thr Uncertain significance Single submitter
- ARMC12 p.Leu155His Uncertain significance Single submitter
- ARMC12 p.Leu21Pro Uncertain significance Single submitter
- ARMC12 p.Met195Val Uncertain significance Single submitter
- ARMC12 p.Pro50Ser Uncertain significance Single submitter
- ARMC12 p.Pro6Ala Uncertain significance Single submitter
- ARMC12 p.Ser332Arg Uncertain significance Single submitter
- ARMC12 p.Ser332Gly Uncertain significance Single submitter
- ARMC12 p.Thr339Met Uncertain significance Single submitter
- ARMC12 p.Val18Ile Uncertain significance Single submitter
- ARMC12 p.Val269Met Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- ARMC12 p.Ala104Val Uncertain significance Single submitter
- ARMC12 p.Arg15Cys Uncertain significance Single submitter
- ARMC12 p.Arg257Trp Uncertain significance Single submitter
- ARMC12 p.Arg262Trp Uncertain significance Single submitter
- ARMC12 p.Arg293Gln Uncertain significance Single submitter
- ARMC12 p.Arg325Trp Uncertain significance Single submitter
- ARMC12 p.Arg62Trp Uncertain significance Single submitter
- ARMC12 p.Arg95His Uncertain significance Single submitter
- ARMC12 p.Asp163Glu Uncertain significance Single submitter
- ARMC12 p.Asp181Asn Uncertain significance Single submitter
- ARMC12 p.Asp181Gly Uncertain significance Single submitter
- ARMC12 p.Glu156Lys Uncertain significance Single submitter
- ARMC12 p.His280Pro Uncertain significance Single submitter
- ARMC12 p.His91Asp Uncertain significance Single submitter
- ARMC12 p.Leu295Val Uncertain significance Single submitter
- ARMC12 p.Lys153Ile Uncertain significance Single submitter
- ARMC12 p.Lys86Asn Uncertain significance Single submitter
- ARMC12 p.Met118Ile Uncertain significance Single submitter
- ARMC12 p.Met191Val Uncertain significance Single submitter
- ARMC12 p.Ser200Pro Uncertain significance Single submitter
- ARMC12 p.Ser259Asn Uncertain significance Single submitter
- ARMC12 p.Ser288Phe Uncertain significance Single submitter
- ARMC12 p.Ser327Tyr Uncertain significance Single submitter
- ARMC12 p.Thr108Ala Uncertain significance Single submitter
- ARMC12 p.Thr109Met Uncertain significance Single submitter
- ARMC12 p.Thr160Ile Uncertain significance Single submitter
- ARMC12 p.Val154Leu Uncertain significance Single submitter
-
ARMC12 p.Asp201Tyr
Uncertain significance
No assertion criteria
prostate cancer
-
ARMC12 p.Cys229Tyr
Pathogenic
No assertion criteria
spermatogenic failure 90
All ARMC12 variants
Pathogenic 3
- p.Arg211Gln No assertion criteria spermatogenic failure 90 ⚠
- p.Cys229Tyr No assertion criteria spermatogenic failure 90 ⚠
- p.Leu212Pro No assertion criteria spermatogenic failure 90
Likely benign 1
- p.Arg71= Single submitter
Uncertain significance 57
- c.163+10C>T Single submitter
- c.163+19G>C Single submitter
- c.163+38G>C Single submitter
- c.163+52C>G Single submitter
- c.163+54G>A Single submitter
- p.Ala104Val Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala37Ser Single submitter ⚠
- p.Ala85Asp Single submitter ⚠
- p.Arg15Cys Single submitter ⚠
- p.Arg15Pro Single submitter ⚠
- p.Arg257Trp Single submitter ⚠
- p.Arg262Trp Single submitter ⚠
- p.Arg293Gln Single submitter ⚠
- p.Arg325Trp Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn263Lys Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Asp163Glu Single submitter ⚠
- p.Asp181Asn Single submitter ⚠
- p.Asp181Gly Single submitter ⚠
- p.Gln186Arg Single submitter ⚠
- p.Glu156Lys Single submitter ⚠
- p.Glu340Val Single submitter ⚠
- p.Gly116Ser Single submitter ⚠
- p.His184Tyr Single submitter ⚠
- p.His280Pro Single submitter ⚠
- p.His91Asp Single submitter ⚠
- p.Ile313Thr Single submitter ⚠
- p.Leu155His Single submitter ⚠
- p.Leu21Pro Single submitter ⚠
- p.Leu295Val Single submitter ⚠
- p.Lys153Ile Single submitter ⚠
- p.Lys86Asn Single submitter ⚠
- p.Met118Ile Single submitter ⚠
- p.Met191Val Single submitter ⚠
- p.Met195Val Single submitter ⚠
- p.Pro50Ser Single submitter ⚠
- p.Pro6Ala Single submitter ⚠
- p.Ser200Pro Single submitter ⚠
- p.Ser259Asn Single submitter ⚠
- p.Ser288Phe Single submitter ⚠
- p.Ser327Tyr Single submitter ⚠
- p.Ser332Arg Single submitter ⚠
- p.Ser332Gly Single submitter ⚠
- p.Thr108Ala Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Thr160Ile Single submitter ⚠
- p.Thr339Met Single submitter ⚠
- p.Val154Leu Single submitter ⚠
- p.Val18Ile Single submitter ⚠
- p.Val269Met Single submitter ⚠
- c.163+28C>T No assertion criteria
- p.Asp201Tyr No assertion criteria prostate cancer ⚠