ARMC2 — 135 ClinVar variants
All ClinVar germline ARMC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
6 Pathogenic · 2 Likely pathogenic · 1 Conflicting · 8 Benign · 14 Likely benign · 104 Uncertain significance
Full ARMC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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ARMC2 p.Ile185Val
Conflicting
No assertion criteria
ARMC2-related disorder
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC2 p.Ala123Val Uncertain significance Single submitter
- ARMC2 p.Ala143Thr Uncertain significance Single submitter
- ARMC2 p.Ala231Thr Uncertain significance Single submitter
- ARMC2 p.Ala260Pro Uncertain significance Single submitter
- ARMC2 p.Ala495Val Uncertain significance Single submitter
- ARMC2 p.Ala593Ser Uncertain significance Single submitter
- ARMC2 p.Arg107Lys Uncertain significance Single submitter
- ARMC2 p.Arg137Lys Uncertain significance Single submitter
- ARMC2 p.Arg142Gln Uncertain significance Single submitter
- ARMC2 p.Arg505Cys Uncertain significance Single submitter
- ARMC2 p.Arg537His Uncertain significance Single submitter
- ARMC2 p.Arg553His Uncertain significance Single submitter
- ARMC2 p.Arg587Gln Uncertain significance Single submitter
- ARMC2 p.Arg62Ile Uncertain significance Single submitter
- ARMC2 p.Arg91His Uncertain significance Single submitter
- ARMC2 p.Asn550Ser Uncertain significance Single submitter
- ARMC2 p.Asn688Ser Uncertain significance Single submitter
- ARMC2 p.Asn743Ser Uncertain significance Single submitter
- ARMC2 p.Asn801Ser Uncertain significance Single submitter
- ARMC2 p.Asp169Asn Uncertain significance Single submitter
- ARMC2 p.Asp169Gly Uncertain significance Single submitter
- ARMC2 p.Asp769Glu Uncertain significance Single submitter
- ARMC2 p.Gln194Arg Uncertain significance Single submitter
- ARMC2 p.Gln256Lys Uncertain significance Single submitter
- ARMC2 p.Gln586His Uncertain significance Single submitter
- ARMC2 p.Glu257Gln Uncertain significance Single submitter
- ARMC2 p.Gly212Arg Uncertain significance Single submitter
- ARMC2 p.Gly588Asp Uncertain significance Single submitter
- ARMC2 p.Gly701Arg Uncertain significance Single submitter
- ARMC2 p.Gly739Asp Uncertain significance Single submitter
- ARMC2 p.Gly739Val Uncertain significance Single submitter
- ARMC2 p.His219Arg Uncertain significance Single submitter
- ARMC2 p.His833Gln Uncertain significance Single submitter
- ARMC2 p.His856Asp Uncertain significance Single submitter
- ARMC2 p.Ile29Phe Uncertain significance Single submitter
- ARMC2 p.Ile616Val Uncertain significance Single submitter
- ARMC2 p.Leu12Val Uncertain significance Single submitter
- ARMC2 p.Leu255Pro Uncertain significance Single submitter
- ARMC2 p.Leu477Pro Uncertain significance Single submitter
- ARMC2 p.Leu643Pro Uncertain significance Single submitter
-
ARMC2 p.Lys228Arg
Uncertain significance
Single submitter
spermatogenic failure 38
- ARMC2 p.Lys282Thr Uncertain significance Single submitter
- ARMC2 p.Lys548Gln Uncertain significance Single submitter
- ARMC2 p.Lys666Glu Uncertain significance Single submitter
- ARMC2 p.Met167Leu Uncertain significance Single submitter
- ARMC2 p.Phe46Cys Uncertain significance Single submitter
- ARMC2 p.Pro146Leu Uncertain significance Single submitter
- ARMC2 p.Pro597Leu Uncertain significance Single submitter
- ARMC2 p.Pro865Ser Uncertain significance Single submitter
- ARMC2 p.Pro99Leu Uncertain significance Single submitter
- ARMC2 p.Ser111Phe Uncertain significance Single submitter
- ARMC2 p.Ser190Gly Uncertain significance Single submitter
- ARMC2 p.Ser215Ala Uncertain significance Single submitter
- ARMC2 p.Ser31Arg Uncertain significance Single submitter
- ARMC2 p.Thr180Ala Uncertain significance Single submitter
- ARMC2 p.Thr479Met Uncertain significance Single submitter
- ARMC2 p.Thr637Met Uncertain significance Single submitter
- ARMC2 p.Trp269Arg Uncertain significance Single submitter
- ARMC2 p.Tyr504Ser Uncertain significance Single submitter
- ARMC2 p.Tyr640Phe Uncertain significance Single submitter
- ARMC2 p.Val120Glu Uncertain significance Single submitter
- ARMC2 p.Val267Phe Uncertain significance Single submitter
- ARMC2 p.Val490Ile Uncertain significance Single submitter
- ARMC2 p.Arg137Gly Uncertain significance No assertion criteria
Predictors split 44
The independent predictors disagree with each other — read with care.
- ARMC2 p.Ala292Asp Uncertain significance Single submitter
- ARMC2 p.Ala625Gly Uncertain significance Single submitter
- ARMC2 p.Ala655Val Uncertain significance Single submitter
- ARMC2 p.Arg142Trp Uncertain significance Single submitter
- ARMC2 p.Arg361Gly Uncertain significance Single submitter
- ARMC2 p.Arg383Thr Uncertain significance Single submitter
- ARMC2 p.Arg609His Uncertain significance Single submitter
- ARMC2 p.Arg751Cys Uncertain significance Single submitter
- ARMC2 p.Arg751His Uncertain significance Single submitter
- ARMC2 p.Arg85Gly Uncertain significance Single submitter
- ARMC2 p.Arg91Cys Uncertain significance Single submitter
- ARMC2 p.Asn717Ser Uncertain significance Single submitter
- ARMC2 p.Cys293Gly Uncertain significance Single submitter
- ARMC2 p.Cys779Phe Uncertain significance Single submitter
- ARMC2 p.Gly418Val Uncertain significance Single submitter
- ARMC2 p.Gly692Arg Uncertain significance Single submitter
- ARMC2 p.Ile276Met Uncertain significance Single submitter
- ARMC2 p.Ile356Thr Uncertain significance Single submitter
- ARMC2 p.Ile760Thr Uncertain significance Single submitter
- ARMC2 p.Leu144Phe Uncertain significance Single submitter
- ARMC2 p.Leu349Ile Uncertain significance Single submitter
- ARMC2 p.Leu469Pro Uncertain significance Single submitter
- ARMC2 p.Leu633Arg Uncertain significance Single submitter
- ARMC2 p.Leu680Ser Uncertain significance Single submitter
- ARMC2 p.Leu811Val Uncertain significance Single submitter
- ARMC2 p.Lys641Glu Uncertain significance Single submitter
- ARMC2 p.Met722Val Uncertain significance Single submitter
- ARMC2 p.Phe72Leu Uncertain significance Single submitter
- ARMC2 p.Pro275Leu Uncertain significance Single submitter
- ARMC2 p.Pro583Ala Uncertain significance Single submitter
- ARMC2 p.Pro596Leu Likely benign Single submitter
- ARMC2 p.Pro628Leu Uncertain significance Single submitter
- ARMC2 p.Pro843His Uncertain significance Single submitter
- ARMC2 p.Ser360Gly Uncertain significance Single submitter
- ARMC2 p.Ser562Asn Uncertain significance Single submitter
- ARMC2 p.Ser796Leu Uncertain significance Single submitter
- ARMC2 p.Thr288Met Uncertain significance Single submitter
- ARMC2 p.Thr572Met Uncertain significance Single submitter
- ARMC2 p.Val420Ala Uncertain significance Single submitter
- ARMC2 p.Val420Gly Uncertain significance Single submitter
- ARMC2 p.Val451Met Likely benign Single submitter
- ARMC2 p.Val459Leu Uncertain significance Single submitter
-
ARMC2 p.Ile760Asn
Pathogenic
No assertion criteria
male infertility with teratozoospermia due to single gene mutation
-
ARMC2 p.Thr546Met
Benign
No assertion criteria
ARMC2-related disorder
All ARMC2 variants
Pathogenic 6
- p.Pro94fs Single submitter
- c.1023+1G>A No assertion criteria male infertility with teratozoospermia due to single gene mutation
- p.Gln141Ter No assertion criteria male infertility with teratozoospermia due to single gene mutation
- p.Ile760Asn No assertion criteria male infertility with teratozoospermia due to single gene mutation ⚠
- p.Leu785fs No assertion criteria male infertility with teratozoospermia due to single gene mutation
- p.Lys428fs No assertion criteria male infertility with teratozoospermia due to single gene mutation
Likely pathogenic 2
- c.2153-1G>C Single submitter spermatogenic failure 38
- p.Asn743Asp Single submitter Reduced sperm motility
Conflicting classifications of pathogenicity 1
- p.Ile185Val No assertion criteria ARMC2-related disorder ⚠
Benign 8
- c.219-4C>T No assertion criteria ARMC2-related disorder
- p.Ala184Val No assertion criteria ARMC2-related disorder
- p.Ala593= No assertion criteria ARMC2-related disorder
- p.Gly438= No assertion criteria ARMC2-related disorder
- p.Ile630Val No assertion criteria ARMC2-related disorder
- p.Met166Thr No assertion criteria ARMC2-related disorder
- p.Pro99= No assertion criteria ARMC2-related disorder
- p.Thr546Met No assertion criteria ARMC2-related disorder ⚠
Likely benign 14
- p.Arg278His Single submitter
- p.Asn130Ser Single submitter
- p.Gln52Pro Single submitter
- p.His707Arg Single submitter
- p.Leu135= Single submitter
- p.Leu849= Single submitter
- p.Met171Val Single submitter
- p.Phe136= Single submitter
- p.Pro596Leu Single submitter ⚠
- p.Ser218= Single submitter
- p.Ser71= Single submitter
- p.Val451Met Single submitter ⚠
- p.Val709Ile Single submitter
- p.Pro622= No assertion criteria ARMC2-related disorder
Uncertain significance 104
- p.Ala123Val Single submitter ⚠
- p.Ala143Thr Single submitter ⚠
- p.Ala231Thr Single submitter ⚠
- p.Ala260Pro Single submitter ⚠
- p.Ala292Asp Single submitter ⚠
- p.Ala495Val Single submitter ⚠
- p.Ala593Ser Single submitter ⚠
- p.Ala625Gly Single submitter ⚠
- p.Ala655Val Single submitter ⚠
- p.Arg107Lys Single submitter ⚠
- p.Arg137Lys Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg361Gly Single submitter ⚠
- p.Arg383Thr Single submitter ⚠
- p.Arg505Cys Single submitter ⚠
- p.Arg537His Single submitter ⚠
- p.Arg553His Single submitter ⚠
- p.Arg587Gln Single submitter ⚠
- p.Arg609His Single submitter ⚠
- p.Arg62Ile Single submitter ⚠
- p.Arg751Cys Single submitter ⚠
- p.Arg751His Single submitter ⚠
- p.Arg85Gly Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Asn550Ser Single submitter ⚠
- p.Asn688Ser Single submitter ⚠
- p.Asn717Ser Single submitter ⚠
- p.Asn743Ser Single submitter ⚠
- p.Asn801Ser Single submitter ⚠
- p.Asp169Asn Single submitter ⚠
- p.Asp169Gly Single submitter ⚠
- p.Asp769Glu Single submitter ⚠
- p.Cys293Gly Single submitter ⚠
- p.Cys779Phe Single submitter ⚠
- p.Gln194Arg Single submitter ⚠
- p.Gln256Lys Single submitter ⚠
- p.Gln586His Single submitter ⚠
- p.Glu257Gln Single submitter ⚠
- p.Gly212Arg Single submitter ⚠
- p.Gly418Val Single submitter ⚠
- p.Gly588Asp Single submitter ⚠
- p.Gly692Arg Single submitter ⚠
- p.Gly701Arg Single submitter ⚠
- p.Gly739Asp Single submitter ⚠
- p.Gly739Val Single submitter ⚠
- p.His219Arg Single submitter ⚠
- p.His833Gln Single submitter ⚠
- p.His856Asp Single submitter ⚠
- p.Ile276Met Single submitter ⚠
- p.Ile29Phe Single submitter ⚠
- p.Ile356Thr Single submitter ⚠
- p.Ile616Val Single submitter ⚠
- p.Ile760Thr Single submitter ⚠
- p.Leu12Val Single submitter ⚠
- p.Leu144Phe Single submitter ⚠
- p.Leu255Pro Single submitter ⚠
- p.Leu349Ile Single submitter ⚠
- p.Leu469Pro Single submitter ⚠
- p.Leu477Pro Single submitter ⚠
- p.Leu633Arg Single submitter ⚠
- p.Leu643Pro Single submitter ⚠
- p.Leu680Ser Single submitter ⚠
- p.Leu811Val Single submitter ⚠
- p.Lys228Arg Single submitter spermatogenic failure 38 ⚠
- p.Lys282Thr Single submitter ⚠
- p.Lys548Gln Single submitter ⚠
- p.Lys641Glu Single submitter ⚠
- p.Lys666Glu Single submitter ⚠
- p.Met167Leu Single submitter ⚠
- p.Met722Val Single submitter ⚠
- p.Phe46Cys Single submitter ⚠
- p.Phe72Leu Single submitter ⚠
- p.Pro146Leu Single submitter ⚠
- p.Pro275Leu Single submitter ⚠
- p.Pro583Ala Single submitter ⚠
- p.Pro597Leu Single submitter ⚠
- p.Pro628Leu Single submitter ⚠
- p.Pro843His Single submitter ⚠
- p.Pro865Ser Single submitter ⚠
- p.Pro99Leu Single submitter ⚠
- p.Ser111Phe Single submitter ⚠
- p.Ser190Gly Single submitter ⚠
- p.Ser215Ala Single submitter ⚠
- p.Ser31Arg Single submitter ⚠
- p.Ser360Gly Single submitter ⚠
- p.Ser562Asn Single submitter ⚠
- p.Ser796Leu Single submitter ⚠
- p.Thr180Ala Single submitter ⚠
- p.Thr288Met Single submitter ⚠
- p.Thr479Met Single submitter ⚠
- p.Thr572Met Single submitter ⚠
- p.Thr637Met Single submitter ⚠
- p.Trp269Arg Single submitter ⚠
- p.Tyr504Ser Single submitter ⚠
- p.Tyr640Phe Single submitter ⚠
- p.Val120Glu Single submitter ⚠
- p.Val267Phe Single submitter ⚠
- p.Val420Ala Single submitter ⚠
- p.Val420Gly Single submitter ⚠
- p.Val459Leu Single submitter ⚠
- p.Val490Ile Single submitter ⚠
- p.Arg137Gly No assertion criteria ⚠