ARMC3 — 125 ClinVar variants
All ClinVar germline ARMC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 120 flagged for review →
5 Likely benign · 120 Uncertain significance
Full ARMC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 120
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC3 p.Ala118Thr Uncertain significance Single submitter
- ARMC3 p.Ala138Ser Uncertain significance Single submitter
- ARMC3 p.Ala416Thr Uncertain significance Single submitter
- ARMC3 p.Arg373Gln Uncertain significance Single submitter
- ARMC3 p.Arg411Gln Uncertain significance Single submitter
- ARMC3 p.Arg432Leu Uncertain significance Single submitter
- ARMC3 p.Arg535Gln Uncertain significance Single submitter
- ARMC3 p.Arg599Gln Uncertain significance Single submitter
- ARMC3 p.Arg862Lys Uncertain significance Single submitter
- ARMC3 p.Asn259Lys Uncertain significance Single submitter
- ARMC3 p.Asn259Ser Uncertain significance Single submitter
- ARMC3 p.Asn369Ser Uncertain significance Single submitter
- ARMC3 p.Asp351Val Uncertain significance Single submitter
- ARMC3 p.Asp618Asn Uncertain significance Single submitter
- ARMC3 p.Asp80Asn Uncertain significance Single submitter
- ARMC3 p.Asp832His Uncertain significance Single submitter
- ARMC3 p.Cys260Ser Uncertain significance Single submitter
- ARMC3 p.Cys716Arg Uncertain significance Single submitter
- ARMC3 p.Gln356Leu Uncertain significance Single submitter
- ARMC3 p.Gln360Glu Uncertain significance Single submitter
- ARMC3 p.Glu10Val Uncertain significance Single submitter
- ARMC3 p.Glu511Lys Uncertain significance Single submitter
- ARMC3 p.Gly2Asp Uncertain significance Single submitter
- ARMC3 p.Gly560Asp Uncertain significance Single submitter
- ARMC3 p.Gly812Cys Uncertain significance Single submitter
- ARMC3 p.Gly818Arg Uncertain significance Single submitter
- ARMC3 p.Gly821Ser Uncertain significance Single submitter
- ARMC3 p.Ile238Val Uncertain significance Single submitter
- ARMC3 p.Ile251Val Uncertain significance Single submitter
- ARMC3 p.Ile440Leu Uncertain significance Single submitter
- ARMC3 p.Ile445Val Uncertain significance Single submitter
- ARMC3 p.Ile567Thr Uncertain significance Single submitter
- ARMC3 p.Ile773Lys Uncertain significance Single submitter
- ARMC3 p.Ile811Thr Uncertain significance Single submitter
- ARMC3 p.Ile82Thr Uncertain significance Single submitter
- ARMC3 p.Ile872Thr Uncertain significance Single submitter
- ARMC3 p.Leu152Ile Uncertain significance Single submitter
- ARMC3 p.Leu187Pro Uncertain significance Single submitter
- ARMC3 p.Leu249Pro Uncertain significance Single submitter
- ARMC3 p.Leu63Val Uncertain significance Single submitter
- ARMC3 p.Leu829Pro Uncertain significance Single submitter
- ARMC3 p.Lys301Arg Uncertain significance Single submitter
- ARMC3 p.Met227Val Uncertain significance Single submitter
- ARMC3 p.Met427Ile Uncertain significance Single submitter
- ARMC3 p.Met427Thr Uncertain significance Single submitter
- ARMC3 p.Met725Thr Uncertain significance Single submitter
- ARMC3 p.Pro164Leu Uncertain significance Single submitter
- ARMC3 p.Pro612Gln Uncertain significance Single submitter
- ARMC3 p.Ser540Arg Uncertain significance Single submitter
- ARMC3 p.Thr474Asn Uncertain significance Single submitter
- ARMC3 p.Thr559Ser Uncertain significance Single submitter
- ARMC3 p.Trp681Leu Uncertain significance Single submitter
- ARMC3 p.Trp769Arg Uncertain significance Single submitter
- ARMC3 p.Tyr175Phe Uncertain significance Single submitter
- ARMC3 p.Tyr561Cys Uncertain significance Single submitter
- ARMC3 p.Tyr647Asn Uncertain significance Single submitter
- ARMC3 p.Val124Leu Uncertain significance Single submitter
- ARMC3 p.Val322Leu Uncertain significance Single submitter
- ARMC3 p.Val470Ala Uncertain significance Single submitter
- ARMC3 p.Val470Asp Uncertain significance Single submitter
- ARMC3 p.Val470Ile Uncertain significance Single submitter
- ARMC3 p.Val531Ile Uncertain significance Single submitter
- ARMC3 p.Val610Ile Uncertain significance Single submitter
- ARMC3 p.Val610Phe Uncertain significance Single submitter
Predictors split 56
The independent predictors disagree with each other — read with care.
- ARMC3 p.Met441Ile Uncertain significance Multiple submitters
- ARMC3 p.Ala115Asp Uncertain significance Single submitter
- ARMC3 p.Ala192Ser Uncertain significance Single submitter
- ARMC3 p.Ala211Val Uncertain significance Single submitter
- ARMC3 p.Ala335Thr Uncertain significance Single submitter
- ARMC3 p.Ala394Ser Uncertain significance Single submitter
- ARMC3 p.Ala426Val Uncertain significance Single submitter
- ARMC3 p.Arg309Ile Uncertain significance Single submitter
- ARMC3 p.Arg373Trp Likely benign Single submitter
- ARMC3 p.Arg473Gln Uncertain significance Single submitter
- ARMC3 p.Arg599Trp Uncertain significance Single submitter
- ARMC3 p.Arg667Gln Uncertain significance Single submitter
- ARMC3 p.Arg834Trp Uncertain significance Single submitter
- ARMC3 p.Asn231Ser Uncertain significance Single submitter
- ARMC3 p.Asn545Thr Uncertain significance Single submitter
- ARMC3 p.Asn551Ser Uncertain significance Single submitter
- ARMC3 p.Asp570Asn Uncertain significance Single submitter
- ARMC3 p.Gln292Arg Uncertain significance Single submitter
- ARMC3 p.Glu122Val Uncertain significance Single submitter
- ARMC3 p.Glu589Lys Uncertain significance Single submitter
- ARMC3 p.Glu70Gly Uncertain significance Single submitter
- ARMC3 p.Glu753Gly Uncertain significance Single submitter
- ARMC3 p.Glu770Gln Uncertain significance Single submitter
- ARMC3 p.Gly560Cys Uncertain significance Single submitter
- ARMC3 p.Gly571Val Uncertain significance Single submitter
- ARMC3 p.Gly581Ser Uncertain significance Single submitter
- ARMC3 p.Gly821Val Uncertain significance Single submitter
- ARMC3 p.Ile578Thr Uncertain significance Single submitter
- ARMC3 p.Leu197Val Uncertain significance Single submitter
- ARMC3 p.Leu254Phe Uncertain significance Single submitter
- ARMC3 p.Leu448Met Uncertain significance Single submitter
- ARMC3 p.Lys7Thr Uncertain significance Single submitter
- ARMC3 p.Met33Ile Uncertain significance Single submitter
- ARMC3 p.Met425Val Uncertain significance Single submitter
- ARMC3 p.Met828Ile Uncertain significance Single submitter
- ARMC3 p.Met89Val Uncertain significance Single submitter
- ARMC3 p.Phe778Ser Uncertain significance Single submitter
- ARMC3 p.Pro164Gln Uncertain significance Single submitter
- ARMC3 p.Pro205Ala Uncertain significance Single submitter
- ARMC3 p.Pro402Thr Uncertain significance Single submitter
- ARMC3 p.Pro430Leu Uncertain significance Single submitter
- ARMC3 p.Pro595Gln Uncertain significance Single submitter
- ARMC3 p.Pro718Leu Uncertain significance Single submitter
- ARMC3 p.Ser170Phe Uncertain significance Single submitter
- ARMC3 p.Ser327Phe Uncertain significance Single submitter
- ARMC3 p.Ser479Tyr Uncertain significance Single submitter
- ARMC3 p.Ser564Leu Uncertain significance Single submitter
- ARMC3 p.Ser650Arg Uncertain significance Single submitter
- ARMC3 p.Thr29Asn Uncertain significance Single submitter
- ARMC3 p.Thr29Ser Uncertain significance Single submitter
- ARMC3 p.Thr676Ile Uncertain significance Single submitter
- ARMC3 p.Thr88Ile Uncertain significance Single submitter
- ARMC3 p.Tyr573His Uncertain significance Single submitter
- ARMC3 p.Tyr573Phe Uncertain significance Single submitter
- ARMC3 p.Tyr750Cys Uncertain significance Single submitter
- ARMC3 p.Val421Ile Uncertain significance Single submitter
All ARMC3 variants
Likely benign 5
- p.Arg373Trp Single submitter ⚠
- p.Asn392= Single submitter
- p.Gly521= Single submitter
- p.Pro760Thr Single submitter
- p.Asn98= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 120
- p.Met441Ile Multiple submitters ⚠
- c.916+1G>A Single submitter ARMC3-related disorder
- p.Ala115Asp Single submitter ⚠
- p.Ala118Thr Single submitter ⚠
- p.Ala138Ser Single submitter ⚠
- p.Ala192Ser Single submitter ⚠
- p.Ala211Val Single submitter ⚠
- p.Ala335Thr Single submitter ⚠
- p.Ala394Ser Single submitter ⚠
- p.Ala416Thr Single submitter ⚠
- p.Ala426Val Single submitter ⚠
- p.Arg309Ile Single submitter ⚠
- p.Arg373Gln Single submitter ⚠
- p.Arg411Gln Single submitter ⚠
- p.Arg432Leu Single submitter ⚠
- p.Arg473Gln Single submitter ⚠
- p.Arg535Gln Single submitter ⚠
- p.Arg599Gln Single submitter ⚠
- p.Arg599Trp Single submitter ⚠
- p.Arg667Gln Single submitter ⚠
- p.Arg834Trp Single submitter ⚠
- p.Arg862Lys Single submitter ⚠
- p.Asn231Ser Single submitter ⚠
- p.Asn259Lys Single submitter ⚠
- p.Asn259Ser Single submitter ⚠
- p.Asn369Ser Single submitter ⚠
- p.Asn545Thr Single submitter ⚠
- p.Asn551Ser Single submitter ⚠
- p.Asp351Val Single submitter ⚠
- p.Asp570Asn Single submitter ⚠
- p.Asp618Asn Single submitter ⚠
- p.Asp80Asn Single submitter ⚠
- p.Asp832His Single submitter ⚠
- p.Cys260Ser Single submitter ⚠
- p.Cys716Arg Single submitter ⚠
- p.Gln292Arg Single submitter ⚠
- p.Gln356Leu Single submitter ⚠
- p.Gln360Glu Single submitter ⚠
- p.Glu10Val Single submitter ⚠
- p.Glu122Val Single submitter ⚠
- p.Glu511Lys Single submitter ⚠
- p.Glu589Lys Single submitter ⚠
- p.Glu70Gly Single submitter ⚠
- p.Glu753Gly Single submitter ⚠
- p.Glu770Gln Single submitter ⚠
- p.Gly2Asp Single submitter ⚠
- p.Gly560Asp Single submitter ⚠
- p.Gly560Cys Single submitter ⚠
- p.Gly571Val Single submitter ⚠
- p.Gly581Ser Single submitter ⚠
- p.Gly812Cys Single submitter ⚠
- p.Gly818Arg Single submitter ⚠
- p.Gly821Ser Single submitter ⚠
- p.Gly821Val Single submitter ⚠
- p.Ile238Val Single submitter ⚠
- p.Ile251Val Single submitter ⚠
- p.Ile440Leu Single submitter ⚠
- p.Ile445Val Single submitter ⚠
- p.Ile567Thr Single submitter ⚠
- p.Ile578Thr Single submitter ⚠
- p.Ile773Lys Single submitter ⚠
- p.Ile811Thr Single submitter ⚠
- p.Ile82Thr Single submitter ⚠
- p.Ile872Thr Single submitter ⚠
- p.Leu152Ile Single submitter ⚠
- p.Leu187Pro Single submitter ⚠
- p.Leu197Val Single submitter ⚠
- p.Leu249Pro Single submitter ⚠
- p.Leu254Phe Single submitter ⚠
- p.Leu448Met Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Leu829Pro Single submitter ⚠
- p.Lys301Arg Single submitter ⚠
- p.Lys7Thr Single submitter ⚠
- p.Met227Val Single submitter ⚠
- p.Met33Ile Single submitter ⚠
- p.Met425Val Single submitter ⚠
- p.Met427Ile Single submitter ⚠
- p.Met427Thr Single submitter ⚠
- p.Met725Thr Single submitter ⚠
- p.Met828Ile Single submitter ⚠
- p.Met89Val Single submitter ⚠
- p.Phe778Ser Single submitter ⚠
- p.Pro164Gln Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Pro205Ala Single submitter ⚠
- p.Pro402Thr Single submitter ⚠
- p.Pro430Leu Single submitter ⚠
- p.Pro595Gln Single submitter ⚠
- p.Pro612Gln Single submitter ⚠
- p.Pro718Leu Single submitter ⚠
- p.Ser170Phe Single submitter ⚠
- p.Ser327Phe Single submitter ⚠
- p.Ser479Tyr Single submitter ⚠
- p.Ser540Arg Single submitter ⚠
- p.Ser564Leu Single submitter ⚠
- p.Ser650Arg Single submitter ⚠
- p.Thr29Asn Single submitter ⚠
- p.Thr29Ser Single submitter ⚠
- p.Thr474Asn Single submitter ⚠
- p.Thr559Ser Single submitter ⚠
- p.Thr676Ile Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Trp681Leu Single submitter ⚠
- p.Trp769Arg Single submitter ⚠
- p.Tyr175Phe Single submitter ⚠
- p.Tyr561Cys Single submitter ⚠
- p.Tyr573His Single submitter ⚠
- p.Tyr573Phe Single submitter ⚠
- p.Tyr647Asn Single submitter ⚠
- p.Tyr750Cys Single submitter ⚠
- p.Val124Leu Single submitter ⚠
- p.Val322Leu Single submitter ⚠
- p.Val421Ile Single submitter ⚠
- p.Val470Ala Single submitter ⚠
- p.Val470Asp Single submitter ⚠
- p.Val470Ile Single submitter ⚠
- p.Val531Ile Single submitter ⚠
- p.Val610Ile Single submitter ⚠
- p.Val610Phe Single submitter ⚠