ARMC6 — 83 ClinVar variants
All ClinVar germline ARMC6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
7 Likely benign · 76 Uncertain significance
Full ARMC6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC6 p.Ala132Val Uncertain significance Single submitter
- ARMC6 p.Ala447Val Uncertain significance Single submitter
- ARMC6 p.Arg213Trp Uncertain significance Single submitter
- ARMC6 p.Arg352Pro Uncertain significance Single submitter
- ARMC6 p.Asn160Ser Uncertain significance Single submitter
- ARMC6 p.Gln85Arg Uncertain significance Single submitter
- ARMC6 p.Gly16Ser Uncertain significance Single submitter
- ARMC6 p.Gly339Asp Uncertain significance Single submitter
- ARMC6 p.Gly413Arg Uncertain significance Single submitter
- ARMC6 p.His235Arg Uncertain significance Single submitter
- ARMC6 p.His263Asn Uncertain significance Single submitter
- ARMC6 p.His332Asp Uncertain significance Single submitter
- ARMC6 p.Ile140Val Uncertain significance Single submitter
- ARMC6 p.Ile408Asn Uncertain significance Single submitter
- ARMC6 p.Leu155Val Uncertain significance Single submitter
- ARMC6 p.Leu316Val Uncertain significance Single submitter
- ARMC6 p.Leu453Val Uncertain significance Single submitter
- ARMC6 p.Leu479Pro Uncertain significance Single submitter
- ARMC6 p.Lys125Glu Uncertain significance Single submitter
- ARMC6 p.Lys274Glu Uncertain significance Single submitter
- ARMC6 p.Met462Ile Uncertain significance Single submitter
- ARMC6 p.Ser320Asn Uncertain significance Single submitter
- ARMC6 p.Ser64Leu Uncertain significance Single submitter
- ARMC6 p.Thr230Ile Uncertain significance Single submitter
- ARMC6 p.Val340Ile Uncertain significance Single submitter
- ARMC6 p.Val79Leu Uncertain significance Single submitter
Predictors split 53
The independent predictors disagree with each other — read with care.
- ARMC6 p.Ala131Thr Uncertain significance Single submitter
- ARMC6 p.Ala131Val Uncertain significance Single submitter
- ARMC6 p.Ala161Val Uncertain significance Single submitter
- ARMC6 p.Ala32Gly Uncertain significance Single submitter
- ARMC6 p.Ala355Thr Uncertain significance Single submitter
- ARMC6 p.Ala392Thr Uncertain significance Single submitter
- ARMC6 p.Ala457Thr Uncertain significance Single submitter
- ARMC6 p.Ala459Val Uncertain significance Single submitter
- ARMC6 p.Ala477Ser Uncertain significance Single submitter
- ARMC6 p.Arg116Cys Uncertain significance Single submitter
- ARMC6 p.Arg128Cys Uncertain significance Single submitter
- ARMC6 p.Arg30His Uncertain significance Single submitter
- ARMC6 p.Arg400His Uncertain significance Single submitter
- ARMC6 p.Arg406Cys Uncertain significance Single submitter
- ARMC6 p.Arg406His Uncertain significance Single submitter
- ARMC6 p.Arg41Cys Uncertain significance Single submitter
- ARMC6 p.Arg41His Uncertain significance Single submitter
- ARMC6 p.Arg465Gln Uncertain significance Single submitter
- ARMC6 p.Arg469His Uncertain significance Single submitter
- ARMC6 p.Arg480Gln Uncertain significance Single submitter
- ARMC6 p.Asp252Asn Uncertain significance Single submitter
- ARMC6 p.Asp358Asn Uncertain significance Single submitter
- ARMC6 p.Asp359Asn Uncertain significance Single submitter
- ARMC6 p.Asp97Tyr Uncertain significance Single submitter
- ARMC6 p.Gln346Lys Uncertain significance Single submitter
- ARMC6 p.Glu272Gln Uncertain significance Single submitter
- ARMC6 p.Glu281Lys Uncertain significance Single submitter
- ARMC6 p.Glu42Lys Uncertain significance Single submitter
- ARMC6 p.Glu45Lys Uncertain significance Single submitter
- ARMC6 p.Glu487Ala Uncertain significance Single submitter
- ARMC6 p.Glu487Lys Uncertain significance Single submitter
- ARMC6 p.Gly220Ser Uncertain significance Single submitter
- ARMC6 p.His232Arg Uncertain significance Single submitter
- ARMC6 p.Leu159Phe Uncertain significance Single submitter
- ARMC6 p.Leu325Val Uncertain significance Single submitter
- ARMC6 p.Leu326Val Uncertain significance Single submitter
- ARMC6 p.Leu343Phe Uncertain significance Single submitter
- ARMC6 p.Leu441Val Uncertain significance Single submitter
- ARMC6 p.Met26Thr Uncertain significance Single submitter
- ARMC6 p.Met421Val Uncertain significance Single submitter
- ARMC6 p.Met436Val Uncertain significance Single submitter
- ARMC6 p.Phe117Leu Uncertain significance Single submitter
- ARMC6 p.Pro290Thr Uncertain significance Single submitter
- ARMC6 p.Pro425Leu Uncertain significance Single submitter
- ARMC6 p.Ser163Leu Uncertain significance Single submitter
- ARMC6 p.Ser2Asn Likely benign Single submitter
- ARMC6 p.Ser449Trp Uncertain significance Single submitter
- ARMC6 p.Ser96Gly Uncertain significance Single submitter
- ARMC6 p.Thr184Met Uncertain significance Single submitter
- ARMC6 p.Thr18Met Likely benign Single submitter
- ARMC6 p.Thr370Met Uncertain significance Single submitter
- ARMC6 p.Thr75Met Likely benign Single submitter
- ARMC6 p.Val374Met Uncertain significance Single submitter
All ARMC6 variants
Likely benign 7
- p.Arg366His Single submitter
- p.Arg489Gln Single submitter
- p.Asn330Ser Single submitter
- p.Gly339Ser Single submitter
- p.Ser2Asn Single submitter ⚠
- p.Thr18Met Single submitter ⚠
- p.Thr75Met Single submitter ⚠
Uncertain significance 76
- p.Ala131Thr Single submitter ⚠
- p.Ala131Val Single submitter ⚠
- p.Ala132Val Single submitter ⚠
- p.Ala161Val Single submitter ⚠
- p.Ala32Gly Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Ala392Thr Single submitter ⚠
- p.Ala447Val Single submitter ⚠
- p.Ala457Thr Single submitter ⚠
- p.Ala459Val Single submitter ⚠
- p.Ala477Ser Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg128Cys Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Arg352Pro Single submitter ⚠
- p.Arg400His Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg41Cys Single submitter ⚠
- p.Arg41His Single submitter ⚠
- p.Arg465Gln Single submitter ⚠
- p.Arg469His Single submitter ⚠
- p.Arg480Gln Single submitter ⚠
- p.Asn160Ser Single submitter ⚠
- p.Asp252Asn Single submitter ⚠
- p.Asp358Asn Single submitter ⚠
- p.Asp359Asn Single submitter ⚠
- p.Asp97Tyr Single submitter ⚠
- p.Gln346Lys Single submitter ⚠
- p.Gln85Arg Single submitter ⚠
- p.Glu272Gln Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Glu487Ala Single submitter ⚠
- p.Glu487Lys Single submitter ⚠
- p.Gly16Ser Single submitter ⚠
- p.Gly220Ser Single submitter ⚠
- p.Gly339Asp Single submitter ⚠
- p.Gly413Arg Single submitter ⚠
- p.His232Arg Single submitter ⚠
- p.His235Arg Single submitter ⚠
- p.His263Asn Single submitter ⚠
- p.His332Asp Single submitter ⚠
- p.Ile140Val Single submitter ⚠
- p.Ile408Asn Single submitter ⚠
- p.Leu155Val Single submitter ⚠
- p.Leu159Phe Single submitter ⚠
- p.Leu316Val Single submitter ⚠
- p.Leu325Val Single submitter ⚠
- p.Leu326Val Single submitter ⚠
- p.Leu343Phe Single submitter ⚠
- p.Leu441Val Single submitter ⚠
- p.Leu453Val Single submitter ⚠
- p.Leu479Pro Single submitter ⚠
- p.Lys125Glu Single submitter ⚠
- p.Lys274Glu Single submitter ⚠
- p.Met26Thr Single submitter ⚠
- p.Met421Val Single submitter ⚠
- p.Met436Val Single submitter ⚠
- p.Met462Ile Single submitter ⚠
- p.Phe117Leu Single submitter ⚠
- p.Pro290Thr Single submitter ⚠
- p.Pro425Leu Single submitter ⚠
- p.Ser163Leu Single submitter ⚠
- p.Ser320Asn Single submitter ⚠
- p.Ser449Trp Single submitter ⚠
- p.Ser64Leu Single submitter ⚠
- p.Ser96Gly Single submitter ⚠
- p.Thr184Met Single submitter ⚠
- p.Thr230Ile Single submitter ⚠
- p.Thr370Met Single submitter ⚠
- p.Val340Ile Single submitter ⚠
- p.Val374Met Single submitter ⚠
- p.Val79Leu Single submitter ⚠