ARMC7 — 35 ClinVar variants
All ClinVar germline ARMC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
4 Likely benign · 31 Uncertain significance
Full ARMC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMC7 p.Ala181Val Uncertain significance Single submitter
- ARMC7 p.Ala19Glu Uncertain significance Single submitter
- ARMC7 p.Arg155Ser Uncertain significance Single submitter
- ARMC7 p.Arg155Thr Uncertain significance Single submitter
- ARMC7 p.Arg179Gln Uncertain significance Single submitter
- ARMC7 p.Arg198His Uncertain significance Single submitter
- ARMC7 p.Arg88Lys Uncertain significance Single submitter
- ARMC7 p.Asn111Ser Uncertain significance Single submitter
- ARMC7 p.Asn42Ser Uncertain significance Single submitter
- ARMC7 p.Asn49Asp Uncertain significance Single submitter
- ARMC7 p.Phe62Leu Uncertain significance Single submitter
- ARMC7 p.Pro195Ser Uncertain significance Single submitter
- ARMC7 p.Ser108Ala Uncertain significance Single submitter
- ARMC7 p.Ser65Ala Uncertain significance Single submitter
- ARMC7 p.Thr139Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- ARMC7 p.Arg130Cys Uncertain significance Single submitter
- ARMC7 p.Arg147Cys Uncertain significance Single submitter
- ARMC7 p.Arg147His Uncertain significance Single submitter
- ARMC7 p.Arg157Trp Uncertain significance Single submitter
- ARMC7 p.Arg177Cys Uncertain significance Single submitter
- ARMC7 p.Arg177Gly Uncertain significance Single submitter
- ARMC7 p.Asp8Gly Uncertain significance Single submitter
- ARMC7 p.Cys85Gly Uncertain significance Single submitter
- ARMC7 p.Gln18Arg Uncertain significance Single submitter
- ARMC7 p.Gly12Glu Uncertain significance Single submitter
- ARMC7 p.Pro110Leu Uncertain significance Single submitter
- ARMC7 p.Pro127Leu Uncertain significance Single submitter
- ARMC7 p.Ser169Phe Uncertain significance Single submitter
- ARMC7 p.Ser178Ile Uncertain significance Single submitter
- ARMC7 p.Ser29Gly Uncertain significance Single submitter
- ARMC7 p.Thr137Ile Uncertain significance Single submitter
All ARMC7 variants
Likely benign 4
- p.Arg196Gln Single submitter
- p.Glu51Gln Single submitter
- p.Ser153Asn Single submitter
- p.Val100Ile Single submitter
Uncertain significance 31
- p.Ala181Val Single submitter ⚠
- p.Ala19Glu Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg147Cys Single submitter ⚠
- p.Arg147His Single submitter ⚠
- p.Arg155Ser Single submitter ⚠
- p.Arg155Thr Single submitter ⚠
- p.Arg157Trp Single submitter ⚠
- p.Arg177Cys Single submitter ⚠
- p.Arg177Gly Single submitter ⚠
- p.Arg179Gln Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg88Lys Single submitter ⚠
- p.Asn111Ser Single submitter ⚠
- p.Asn42Ser Single submitter ⚠
- p.Asn49Asp Single submitter ⚠
- p.Asp8Gly Single submitter ⚠
- p.Cys85Gly Single submitter ⚠
- p.Gln18Arg Single submitter ⚠
- p.Gly12Glu Single submitter ⚠
- p.Phe62Leu Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro195Ser Single submitter ⚠
- p.Ser108Ala Single submitter ⚠
- p.Ser169Phe Single submitter ⚠
- p.Ser178Ile Single submitter ⚠
- p.Ser29Gly Single submitter ⚠
- p.Ser65Ala Single submitter ⚠
- p.Thr137Ile Single submitter ⚠
- p.Thr139Met Single submitter ⚠