ARMCX1 — 33 ClinVar variants
All ClinVar germline ARMCX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Benign · 3 Likely benign · 29 Uncertain significance
Full ARMCX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMCX1 p.Ala127Val Uncertain significance Single submitter
- ARMCX1 p.Ala165Thr Uncertain significance Single submitter
- ARMCX1 p.Ala64Thr Uncertain significance Single submitter
- ARMCX1 p.Ala7Val Uncertain significance Single submitter
- ARMCX1 p.Arg216Gln Uncertain significance Single submitter
- ARMCX1 p.Arg299Gly Uncertain significance Single submitter
- ARMCX1 p.Arg31Lys Uncertain significance Single submitter
- ARMCX1 p.Asp32Glu Uncertain significance Single submitter
- ARMCX1 p.Glu33Gly Uncertain significance Single submitter
- ARMCX1 p.Gly103Asp Uncertain significance Single submitter
- ARMCX1 p.Gly162Arg Uncertain significance Single submitter
- ARMCX1 p.Gly247Cys Uncertain significance Single submitter
- ARMCX1 p.His153Tyr Uncertain significance Single submitter
- ARMCX1 p.Leu82Ser Uncertain significance Single submitter
- ARMCX1 p.Lys109Glu Uncertain significance Single submitter
- ARMCX1 p.Lys36Glu Uncertain significance Single submitter
- ARMCX1 p.Lys91Glu Uncertain significance Single submitter
- ARMCX1 p.Pro140Thr Uncertain significance Single submitter
- ARMCX1 p.Ser275Thr Uncertain significance Single submitter
- ARMCX1 p.Thr4Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ARMCX1 p.Arg299Cys Uncertain significance Single submitter
- ARMCX1 p.Gly2Cys Uncertain significance Single submitter
- ARMCX1 p.His323Arg Uncertain significance Single submitter
- ARMCX1 p.Leu324Met Uncertain significance Single submitter
- ARMCX1 p.Lys197Thr Uncertain significance Single submitter
- ARMCX1 p.Ser157Asn Uncertain significance Single submitter
- ARMCX1 p.Ser169Tyr Uncertain significance Single submitter
- ARMCX1 p.Ser44Phe Uncertain significance Single submitter
- ARMCX1 p.Val129Met Uncertain significance Single submitter
All ARMCX1 variants
Benign 1
- p.Arg5= Single submitter
Likely benign 3
- p.Ala433= Single submitter
- p.Asn34= Single submitter
- p.Thr267Ala Single submitter
Uncertain significance 29
- p.Ala127Val Single submitter ⚠
- p.Ala165Thr Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg299Cys Single submitter ⚠
- p.Arg299Gly Single submitter ⚠
- p.Arg31Lys Single submitter ⚠
- p.Asp32Glu Single submitter ⚠
- p.Glu33Gly Single submitter ⚠
- p.Gly103Asp Single submitter ⚠
- p.Gly162Arg Single submitter ⚠
- p.Gly247Cys Single submitter ⚠
- p.Gly2Cys Single submitter ⚠
- p.His153Tyr Single submitter ⚠
- p.His323Arg Single submitter ⚠
- p.Leu324Met Single submitter ⚠
- p.Leu82Ser Single submitter ⚠
- p.Lys109Glu Single submitter ⚠
- p.Lys197Thr Single submitter ⚠
- p.Lys36Glu Single submitter ⚠
- p.Lys91Glu Single submitter ⚠
- p.Pro140Thr Single submitter ⚠
- p.Ser157Asn Single submitter ⚠
- p.Ser169Tyr Single submitter ⚠
- p.Ser275Thr Single submitter ⚠
- p.Ser44Phe Single submitter ⚠
- p.Thr4Ile Single submitter ⚠
- p.Val129Met Single submitter ⚠