ARMCX2 — 48 ClinVar variants
All ClinVar germline ARMCX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
4 Likely benign · 44 Uncertain significance
Full ARMCX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMCX2 p.Ala105Pro Uncertain significance Single submitter
- ARMCX2 p.Ala105Thr Uncertain significance Single submitter
- ARMCX2 p.Ala115Ser Uncertain significance Single submitter
- ARMCX2 p.Ala133Thr Uncertain significance Single submitter
- ARMCX2 p.Ala170Gly Uncertain significance Single submitter
- ARMCX2 p.Ala175Thr Uncertain significance Single submitter
- ARMCX2 p.Ala18Ser Uncertain significance Single submitter
- ARMCX2 p.Arg288Gly Uncertain significance Single submitter
- ARMCX2 p.Arg312Cys Uncertain significance Single submitter
- ARMCX2 p.Arg31Thr Uncertain significance Single submitter
- ARMCX2 p.Arg44Gln Uncertain significance Single submitter
- ARMCX2 p.Arg44Gly Uncertain significance Single submitter
- ARMCX2 p.Arg5Gln Uncertain significance Single submitter
- ARMCX2 p.Asn580Ser Uncertain significance Single submitter
- ARMCX2 p.Glu153Gly Uncertain significance Single submitter
- ARMCX2 p.Glu169Lys Uncertain significance Single submitter
- ARMCX2 p.Glu207Ala Uncertain significance Single submitter
- ARMCX2 p.Gly122Trp Uncertain significance Single submitter
- ARMCX2 p.Gly144Arg Uncertain significance Single submitter
- ARMCX2 p.Gly150Arg Uncertain significance Single submitter
- ARMCX2 p.Gly198Glu Uncertain significance Single submitter
- ARMCX2 p.Gly210Arg Uncertain significance Single submitter
- ARMCX2 p.Gly295Ser Uncertain significance Single submitter
- ARMCX2 p.Gly344Arg Uncertain significance Single submitter
- ARMCX2 p.Gly56Arg Uncertain significance Single submitter
- ARMCX2 p.Leu65Val Uncertain significance Single submitter
- ARMCX2 p.Pro143Ser Uncertain significance Single submitter
- ARMCX2 p.Pro279Thr Uncertain significance Single submitter
- ARMCX2 p.Pro72Leu Uncertain significance Single submitter
- ARMCX2 p.Pro74Gln Uncertain significance Single submitter
- ARMCX2 p.Ser354Pro Uncertain significance Single submitter
- ARMCX2 p.Ser533Leu Uncertain significance Single submitter
- ARMCX2 p.Thr225Met Uncertain significance Single submitter
- ARMCX2 p.Thr227Ala Uncertain significance Single submitter
- ARMCX2 p.Thr275Ile Uncertain significance Single submitter
- ARMCX2 p.Thr28Asn Uncertain significance Single submitter
- ARMCX2 p.Thr92Arg Uncertain significance Single submitter
- ARMCX2 p.Val10Leu Uncertain significance Single submitter
- ARMCX2 p.Val250Ile Uncertain significance Single submitter
- ARMCX2 p.Val4Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All ARMCX2 variants
Likely benign 4
- p.Ala170Val Single submitter
- p.Glu563= Single submitter
- p.Leu430= Single submitter
- p.Val98= Single submitter
Uncertain significance 44
- p.Ala105Pro Single submitter ⚠
- p.Ala105Thr Single submitter ⚠
- p.Ala115Ser Single submitter ⚠
- p.Ala133Thr Single submitter ⚠
- p.Ala170Gly Single submitter ⚠
- p.Ala175Thr Single submitter ⚠
- p.Ala18Ser Single submitter ⚠
- p.Arg288Gly Single submitter ⚠
- p.Arg312Cys Single submitter ⚠
- p.Arg31Thr Single submitter ⚠
- p.Arg44Gln Single submitter ⚠
- p.Arg44Gly Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asn580Ser Single submitter ⚠
- p.Glu153Gly Single submitter ⚠
- p.Glu169Lys Single submitter ⚠
- p.Glu207Ala Single submitter ⚠
- p.Gly122Trp Single submitter ⚠
- p.Gly144Arg Single submitter ⚠
- p.Gly150Arg Single submitter ⚠
- p.Gly198Glu Single submitter ⚠
- p.Gly210Arg Single submitter ⚠
- p.Gly295Ser Single submitter ⚠
- p.Gly344Arg Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Leu65Val Single submitter ⚠
- p.Pro143Ser Single submitter ⚠
- p.Pro279Thr Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Pro74Gln Single submitter ⚠
- p.Ser354Pro Single submitter ⚠
- p.Ser533Leu Single submitter ⚠
- p.Ser547Arg Single submitter ⚠
- p.Thr225Met Single submitter ⚠
- p.Thr227Ala Single submitter ⚠
- p.Thr275Ile Single submitter ⚠
- p.Thr28Asn Single submitter ⚠
- p.Thr92Arg Single submitter ⚠
- p.Val10Leu Single submitter ⚠
- p.Val250Ile Single submitter ⚠
- p.Val4Ile Single submitter ⚠
- p.Val562Met Single submitter ⚠
- p.Val605Glu Single submitter ⚠