ARMCX3 — 19 ClinVar variants
All ClinVar germline ARMCX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
1 Likely benign · 18 Uncertain significance
Full ARMCX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMCX3 p.Ala4Val Uncertain significance Single submitter
- ARMCX3 p.Arg100Leu Uncertain significance Single submitter
- ARMCX3 p.Arg102Cys Uncertain significance Single submitter
- ARMCX3 p.Asn315His Uncertain significance Single submitter
- ARMCX3 p.Asp247Glu Uncertain significance Single submitter
- ARMCX3 p.Asp45Val Uncertain significance Single submitter
- ARMCX3 p.Glu319Gly Uncertain significance Single submitter
- ARMCX3 p.Glu36Ala Uncertain significance Single submitter
- ARMCX3 p.Gly329Asp Uncertain significance Single submitter
- ARMCX3 p.Lys170Asn Uncertain significance Single submitter
- ARMCX3 p.Met366Val Uncertain significance Single submitter
- ARMCX3 p.Phe336Val Uncertain significance Single submitter
- ARMCX3 p.Pro120His Uncertain significance Single submitter
- ARMCX3 p.Val10Leu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All ARMCX3 variants
Likely benign 1
- p.Leu261Phe Single submitter
Uncertain significance 18
- p.Ala12Thr Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Arg100Leu Single submitter ⚠
- p.Arg102Cys Single submitter ⚠
- p.Asn315His Single submitter ⚠
- p.Asp247Glu Single submitter ⚠
- p.Asp45Val Single submitter ⚠
- p.Glu319Gly Single submitter ⚠
- p.Glu36Ala Single submitter ⚠
- p.Gly329Asp Single submitter ⚠
- p.Leu303His Single submitter ⚠
- p.Lys170Asn Single submitter ⚠
- p.Met276Ile Single submitter ⚠
- p.Met366Val Single submitter ⚠
- p.Phe336Val Single submitter ⚠
- p.Pro120His Single submitter ⚠
- p.Val10Leu Single submitter ⚠