ARMCX5 — 61 ClinVar variants
All ClinVar germline ARMCX5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
2 Likely benign · 59 Uncertain significance
Full ARMCX5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMCX5 p.Ala540Val Uncertain significance Single submitter
- ARMCX5 p.Ala54Thr Uncertain significance Single submitter
- ARMCX5 p.Ala58Val Uncertain significance Single submitter
- ARMCX5 p.Arg100His Uncertain significance Single submitter
- ARMCX5 p.Arg135Met Uncertain significance Single submitter
- ARMCX5 p.Arg135Ser Uncertain significance Single submitter
- ARMCX5 p.Arg9Lys Uncertain significance Single submitter
- ARMCX5 p.Asn294Asp Uncertain significance Single submitter
- ARMCX5 p.Asn490Asp Uncertain significance Single submitter
- ARMCX5 p.Asp378Glu Uncertain significance Single submitter
- ARMCX5 p.Asp538Gly Uncertain significance Single submitter
- ARMCX5 p.Glu368Gln Uncertain significance Single submitter
- ARMCX5 p.Glu37Gln Uncertain significance Single submitter
- ARMCX5 p.Glu384Lys Uncertain significance Single submitter
- ARMCX5 p.Glu390Asp Uncertain significance Single submitter
- ARMCX5 p.Glu546Lys Uncertain significance Single submitter
- ARMCX5 p.Gly159Arg Uncertain significance Single submitter
- ARMCX5 p.Gly17Ala Uncertain significance Single submitter
- ARMCX5 p.Gly237Ala Uncertain significance Single submitter
- ARMCX5 p.Gly237Arg Uncertain significance Single submitter
- ARMCX5 p.Gly238Glu Uncertain significance Single submitter
- ARMCX5 p.Gly57Arg Uncertain significance Single submitter
- ARMCX5 p.Ile134Val Uncertain significance Single submitter
- ARMCX5 p.Ile158Val Uncertain significance Single submitter
- ARMCX5 p.Ile170Met Uncertain significance Single submitter
- ARMCX5 p.Ile267Phe Uncertain significance Single submitter
- ARMCX5 p.Ile348Val Uncertain significance Single submitter
- ARMCX5 p.Ile495Val Uncertain significance Single submitter
- ARMCX5 p.Leu411Val Uncertain significance Single submitter
- ARMCX5 p.Lys107Glu Uncertain significance Single submitter
- ARMCX5 p.Lys473Arg Uncertain significance Single submitter
- ARMCX5 p.Lys530Ile Uncertain significance Single submitter
- ARMCX5 p.Pro150Ser Uncertain significance Single submitter
- ARMCX5 p.Pro207Ala Uncertain significance Single submitter
- ARMCX5 p.Pro268Ser Uncertain significance Single submitter
- ARMCX5 p.Pro295Leu Uncertain significance Single submitter
- ARMCX5 p.Pro364Leu Uncertain significance Single submitter
- ARMCX5 p.Pro386Thr Uncertain significance Single submitter
- ARMCX5 p.Pro96Ser Uncertain significance Single submitter
- ARMCX5 p.Ser114Pro Uncertain significance Single submitter
- ARMCX5 p.Ser122Cys Uncertain significance Single submitter
- ARMCX5 p.Ser162Phe Uncertain significance Single submitter
- ARMCX5 p.Ser163Arg Uncertain significance Single submitter
- ARMCX5 p.Ser225Ala Uncertain significance Single submitter
- ARMCX5 p.Ser302Pro Uncertain significance Single submitter
- ARMCX5 p.Ser471Gly Uncertain significance Single submitter
- ARMCX5 p.Ser543Gly Uncertain significance Single submitter
- ARMCX5 p.Thr210Lys Uncertain significance Single submitter
- ARMCX5 p.Thr277Ala Uncertain significance Single submitter
- ARMCX5 p.Thr332Ala Uncertain significance Single submitter
- ARMCX5 p.Thr513Ser Uncertain significance Single submitter
- ARMCX5 p.Thr84Ile Uncertain significance Single submitter
- ARMCX5 p.Val2Ala Uncertain significance Single submitter
- ARMCX5 p.Val361Ile Uncertain significance Single submitter
- ARMCX5 p.Val409Gly Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARMCX5 variants
Likely benign 2
- p.Ile422Val Single submitter
- p.Ser383= Single submitter
Uncertain significance 59
- p.Ala540Val Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Ala58Val Single submitter ⚠
- p.Arg100His Single submitter ⚠
- p.Arg135Met Single submitter ⚠
- p.Arg135Ser Single submitter ⚠
- p.Arg467Thr Single submitter ⚠
- p.Arg9Lys Single submitter ⚠
- p.Asn294Asp Single submitter ⚠
- p.Asn490Asp Single submitter ⚠
- p.Asp378Glu Single submitter ⚠
- p.Asp538Gly Single submitter ⚠
- p.Glu368Gln Single submitter ⚠
- p.Glu37Gln Single submitter ⚠
- p.Glu384Lys Single submitter ⚠
- p.Glu390Asp Single submitter ⚠
- p.Glu546Lys Single submitter ⚠
- p.Gly159Arg Single submitter ⚠
- p.Gly17Ala Single submitter ⚠
- p.Gly237Ala Single submitter ⚠
- p.Gly237Arg Single submitter ⚠
- p.Gly238Glu Single submitter ⚠
- p.Gly57Arg Single submitter ⚠
- p.His328Asp Single submitter ⚠
- p.Ile134Val Single submitter ⚠
- p.Ile158Val Single submitter ⚠
- p.Ile170Met Single submitter ⚠
- p.Ile267Phe Single submitter ⚠
- p.Ile348Val Single submitter ⚠
- p.Ile495Val Single submitter ⚠
- p.Leu411Val Single submitter ⚠
- p.Leu453Val Single submitter
- p.Lys107Glu Single submitter ⚠
- p.Lys473Arg Single submitter ⚠
- p.Lys530Ile Single submitter ⚠
- p.Phe450Leu Single submitter ⚠
- p.Pro150Ser Single submitter ⚠
- p.Pro207Ala Single submitter ⚠
- p.Pro268Ser Single submitter ⚠
- p.Pro295Leu Single submitter ⚠
- p.Pro364Leu Single submitter ⚠
- p.Pro386Thr Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Ser114Pro Single submitter ⚠
- p.Ser122Cys Single submitter ⚠
- p.Ser162Phe Single submitter ⚠
- p.Ser163Arg Single submitter ⚠
- p.Ser225Ala Single submitter ⚠
- p.Ser302Pro Single submitter ⚠
- p.Ser471Gly Single submitter ⚠
- p.Ser543Gly Single submitter ⚠
- p.Thr210Lys Single submitter ⚠
- p.Thr277Ala Single submitter ⚠
- p.Thr332Ala Single submitter ⚠
- p.Thr513Ser Single submitter ⚠
- p.Thr84Ile Single submitter ⚠
- p.Val2Ala Single submitter ⚠
- p.Val361Ile Single submitter ⚠
- p.Val409Gly Single submitter ⚠