ARMCX6 — 24 ClinVar variants
All ClinVar germline ARMCX6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
3 Likely benign · 21 Uncertain significance
Full ARMCX6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMCX6 p.Ala115Val Uncertain significance Single submitter
- ARMCX6 p.Ala11Ser Uncertain significance Single submitter
- ARMCX6 p.Ala145Val Uncertain significance Single submitter
- ARMCX6 p.Ala177Asp Uncertain significance Single submitter
- ARMCX6 p.Arg175Gly Uncertain significance Single submitter
- ARMCX6 p.Arg5Trp Uncertain significance Single submitter
- ARMCX6 p.Asn120Ser Uncertain significance Single submitter
- ARMCX6 p.Asn154Ser Uncertain significance Single submitter
- ARMCX6 p.Asp152Tyr Uncertain significance Single submitter
- ARMCX6 p.Asp52His Uncertain significance Single submitter
- ARMCX6 p.Cys118Ser Uncertain significance Single submitter
- ARMCX6 p.Glu141Lys Uncertain significance Single submitter
- ARMCX6 p.Gly73Ala Uncertain significance Single submitter
- ARMCX6 p.Lys110Asn Uncertain significance Single submitter
- ARMCX6 p.Ser159Thr Uncertain significance Single submitter
- ARMCX6 p.Thr166Met Uncertain significance Single submitter
- ARMCX6 p.Trp113Ser Uncertain significance Single submitter
- ARMCX6 p.Trp45Gly Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARMCX6 variants
Likely benign 3
- p.Ala18Val Single submitter ⚠
- p.Ala217= Single submitter
- p.Cys118Phe Single submitter
Uncertain significance 21
- p.Ala115Val Single submitter ⚠
- p.Ala11Ser Single submitter ⚠
- p.Ala12Ser Single submitter
- p.Ala145Val Single submitter ⚠
- p.Ala177Asp Single submitter ⚠
- p.Arg175Gly Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asn120Ser Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asp152Tyr Single submitter ⚠
- p.Asp52His Single submitter ⚠
- p.Cys118Ser Single submitter ⚠
- p.Glu141Lys Single submitter ⚠
- p.Gly73Ala Single submitter ⚠
- p.Gly90Glu Single submitter ⚠
- p.Lys110Asn Single submitter ⚠
- p.Ser159Thr Single submitter ⚠
- p.Thr166Met Single submitter ⚠
- p.Trp113Ser Single submitter ⚠
- p.Trp45Gly Single submitter ⚠
- p.Trp75Cys Single submitter ⚠