ARMH1 — 8 ClinVar variants
All ClinVar germline ARMH1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
2 Benign · 1 Likely benign · 5 Uncertain significance
Full ARMH1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All ARMH1 variants
Benign 2
- p.His177= Multiple submitters
- p.Val250Ile Multiple submitters
Likely benign 1
- p.Gly189Arg Single submitter ⚠
Uncertain significance 5
- p.Ala192Thr Single submitter ⚠
- p.Asp253His Single submitter ⚠
- p.Ile386Thr Single submitter ⚠
- p.Lys304Asn Single submitter ⚠
- p.Ser65Leu Single submitter ⚠