ARMH4 — 10 ClinVar variants
All ClinVar germline ARMH4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
3 Likely benign · 7 Uncertain significance
Full ARMH4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMH4 p.Asp263Gly Uncertain significance Single submitter
- ARMH4 p.Glu320Asp Uncertain significance Single submitter
- ARMH4 p.Glu486Lys Uncertain significance Single submitter
- ARMH4 p.Leu485Ile Uncertain significance Single submitter
- ARMH4 p.Thr562Ala Uncertain significance Single submitter
- ARMH4 p.Val556Asp Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ARMH4 variants
Likely benign 3
- p.Gln542Glu Single submitter
- p.Phe19= Single submitter
- p.Thr376Met Single submitter ⚠
Uncertain significance 7
- p.Asp263Gly Single submitter ⚠
- p.Asp623Gly Single submitter ⚠
- p.Glu320Asp Single submitter ⚠
- p.Glu486Lys Single submitter ⚠
- p.Leu485Ile Single submitter ⚠
- p.Thr562Ala Single submitter ⚠
- p.Val556Asp Single submitter ⚠