ARMS2 — 36 ClinVar variants
All ClinVar germline ARMS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
4 Benign · 5 Benign/Likely benign · 6 Likely benign · 21 Uncertain significance
Full ARMS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMS2 p.Ala79Asp Uncertain significance Single submitter
- ARMS2 p.Arg56Lys Uncertain significance Single submitter
- ARMS2 p.Cys76Arg Uncertain significance Single submitter
- ARMS2 p.Gln91Leu Uncertain significance Single submitter
- ARMS2 p.Glu20Gln Uncertain significance Single submitter
- ARMS2 p.Ile102Phe Uncertain significance Single submitter
- ARMS2 p.Ile102Thr Uncertain significance Single submitter
- ARMS2 p.Ile34Phe Uncertain significance Single submitter
- ARMS2 p.Leu97Val Uncertain significance Single submitter
- ARMS2 p.Met65Val Uncertain significance Single submitter
- ARMS2 p.Pro78Ala Uncertain significance Single submitter
- ARMS2 p.Ser57Asn Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARMS2 variants
Benign 4
- p.Ala69Ser Multiple submitters age related macular degeneration 8
- p.Arg38Ter Multiple submitters age related macular degeneration 8
- p.Arg3His Multiple submitters age related macular degeneration 8
- c.*374G>T Single submitter age related macular degeneration 8
Benign/Likely benign 5
- c.298-13A>G Multiple submitters age related macular degeneration 8
- c.298-13A>T Multiple submitters age related macular degeneration 8
- c.*373T>G Multiple submitters age related macular degeneration 8
- c.*376T>C Multiple submitters age related macular degeneration 8
- c.*385A>C Multiple submitters age related macular degeneration 8
Likely benign 6
- c.*107T>G Multiple submitters age related macular degeneration 8
- c.*45T>G Multiple submitters age related macular degeneration 8
- p.Pro83fs Multiple submitters
- c.-9G>A Single submitter age related macular degeneration 8
- c.*161C>T Single submitter age related macular degeneration 8
- c.*204C>A Single submitter age related macular degeneration 8
Uncertain significance 21
- p.Pro8Leu Multiple submitters age related macular degeneration 8 ⚠
- c.-60G>T Single submitter age related macular degeneration 8
- c.*15A>G Single submitter age related macular degeneration 8
- c.*251T>C Single submitter age related macular degeneration 8
- c.*313G>C Single submitter age related macular degeneration 8
- c.*399A>G Single submitter age related macular degeneration 8
- p.Ala13= Single submitter age related macular degeneration 8
- p.Ala79Asp Single submitter ⚠
- p.Arg56Lys Single submitter ⚠
- p.Cys76Arg Single submitter ⚠
- p.Gln91Leu Single submitter ⚠
- p.Glu20Gln Single submitter ⚠
- p.Ile102Phe Single submitter ⚠
- p.Ile102Thr Single submitter ⚠
- p.Ile34Phe Single submitter ⚠
- p.Leu97Val Single submitter ⚠
- p.Met65Val Single submitter ⚠
- p.Phe80Leu Single submitter ⚠
- p.Pro78Ala Single submitter ⚠
- p.Ser57Asn Single submitter ⚠
- p.Ser82Phe Single submitter ⚠