ARMT1 — 37 ClinVar variants
All ClinVar germline ARMT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Likely benign · 36 Uncertain significance
Full ARMT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARMT1 p.Ala344Gly Uncertain significance Single submitter
- ARMT1 p.Arg24Ile Uncertain significance Single submitter
- ARMT1 p.Asn212Ser Uncertain significance Single submitter
- ARMT1 p.Asp86Asn Uncertain significance Single submitter
- ARMT1 p.Glu341Asp Uncertain significance Single submitter
- ARMT1 p.Glu341Lys Uncertain significance Single submitter
- ARMT1 p.Gly201Glu Uncertain significance Single submitter
- ARMT1 p.Gly439Asp Uncertain significance Single submitter
- ARMT1 p.His125Asn Uncertain significance Single submitter
- ARMT1 p.His306Gln Uncertain significance Single submitter
- ARMT1 p.His386Pro Uncertain significance Single submitter
- ARMT1 p.Ile169Val Uncertain significance Single submitter
- ARMT1 p.Ile285Val Uncertain significance Single submitter
- ARMT1 p.Ile294Val Uncertain significance Single submitter
- ARMT1 p.Ile362Val Uncertain significance Single submitter
- ARMT1 p.Ile59Val Uncertain significance Single submitter
- ARMT1 p.Ile87Val Uncertain significance Single submitter
- ARMT1 p.Leu198Pro Uncertain significance Single submitter
- ARMT1 p.Lys365Arg Uncertain significance Single submitter
- ARMT1 p.Lys365Asn Uncertain significance Single submitter
- ARMT1 p.Met312Ile Uncertain significance Single submitter
- ARMT1 p.Phe140Leu Uncertain significance Single submitter
- ARMT1 p.Phe75Leu Uncertain significance Single submitter
- ARMT1 p.Pro112Leu Uncertain significance Single submitter
- ARMT1 p.Ser102Arg Uncertain significance Single submitter
- ARMT1 p.Ser272Cys Uncertain significance Single submitter
- ARMT1 p.Thr160Ala Uncertain significance Single submitter
- ARMT1 p.Thr261Ala Uncertain significance Single submitter
- ARMT1 p.Thr428Ala Uncertain significance Single submitter
- ARMT1 p.Trp113Cys Uncertain significance Single submitter
- ARMT1 p.Tyr281Cys Uncertain significance Single submitter
- ARMT1 p.Tyr330Asn Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All ARMT1 variants
Likely benign 1
- p.His161Tyr Single submitter
Uncertain significance 36
- p.Ala344Gly Single submitter ⚠
- p.Arg24Ile Single submitter ⚠
- p.Asn212Ser Single submitter ⚠
- p.Asp86Asn Single submitter ⚠
- p.Glu341Asp Single submitter ⚠
- p.Glu341Lys Single submitter ⚠
- p.Gly201Glu Single submitter ⚠
- p.Gly439Asp Single submitter ⚠
- p.His125Asn Single submitter ⚠
- p.His306Gln Single submitter ⚠
- p.His340Arg Single submitter ⚠
- p.His386Pro Single submitter ⚠
- p.Ile169Val Single submitter ⚠
- p.Ile285Val Single submitter ⚠
- p.Ile294Val Single submitter ⚠
- p.Ile362Val Single submitter ⚠
- p.Ile59Val Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu198Pro Single submitter ⚠
- p.Lys365Arg Single submitter ⚠
- p.Lys365Asn Single submitter ⚠
- p.Met312Ile Single submitter ⚠
- p.Met345Val Single submitter
- p.Phe140Leu Single submitter ⚠
- p.Phe75Leu Single submitter ⚠
- p.Pro112Leu Single submitter ⚠
- p.Ser102Arg Single submitter ⚠
- p.Ser272Cys Single submitter ⚠
- p.Thr160Ala Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr293Ala Single submitter ⚠
- p.Thr428Ala Single submitter ⚠
- p.Trp113Cys Single submitter ⚠
- p.Tyr281Cys Single submitter ⚠
- p.Tyr330Asn Single submitter ⚠
- p.Tyr353His Single submitter ⚠