ARPC2 — 20 ClinVar variants
All ClinVar germline ARPC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Benign · 18 Uncertain significance
Full ARPC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARPC2 p.Arg237Gln Uncertain significance Single submitter
- ARPC2 p.Arg267Trp Uncertain significance Single submitter
- ARPC2 p.Arg281Cys Uncertain significance Single submitter
- ARPC2 p.Arg281His Uncertain significance Single submitter
- ARPC2 p.Asn219Asp Uncertain significance Single submitter
- ARPC2 p.Gly81Arg Uncertain significance Single submitter
- ARPC2 p.Leu199Val Uncertain significance Single submitter
- ARPC2 p.Lys136Arg Uncertain significance Single submitter
- ARPC2 p.Met182Val Uncertain significance Single submitter
- ARPC2 p.Phe169Leu Uncertain significance Single submitter
- ARPC2 p.Thr264Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ARPC2 p.Ala69Val Uncertain significance Single submitter
- ARPC2 p.Arg300His Uncertain significance Single submitter
- ARPC2 p.Asn21Ser Uncertain significance Single submitter
- ARPC2 p.Asp51Asn Uncertain significance Single submitter
- ARPC2 p.Met115Val Uncertain significance Single submitter
- ARPC2 p.Phe19Leu Uncertain significance Single submitter
- ARPC2 p.Val31Ile Uncertain significance Single submitter
All ARPC2 variants
Benign 2
- c.677-3C>T Multiple submitters
- p.Leu3= Multiple submitters
Uncertain significance 18
- p.Ala69Val Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg281Cys Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg300His Single submitter ⚠
- p.Asn219Asp Single submitter ⚠
- p.Asn21Ser Single submitter ⚠
- p.Asp51Asn Single submitter ⚠
- p.Gly81Arg Single submitter ⚠
- p.Leu199Val Single submitter ⚠
- p.Lys136Arg Single submitter ⚠
- p.Met115Val Single submitter ⚠
- p.Met182Val Single submitter ⚠
- p.Phe169Leu Single submitter ⚠
- p.Phe19Leu Single submitter ⚠
- p.Thr264Ile Single submitter ⚠
- p.Val31Ile Single submitter ⚠