ARPC4-TTLL3 — 52 ClinVar variants
All ClinVar germline ARPC4-TTLL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1 flagged for review →
52 Uncertain significance
Full ARPC4-TTLL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 1
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All ARPC4-TTLL3 variants
Uncertain significance 52
- p.Ala272Pro Single submitter
- p.Ala282Val Single submitter
- p.Ala516Thr Single submitter
- p.Ala533Thr Single submitter
- p.Arg125Trp Single submitter
- p.Arg129His Single submitter
- p.Arg207Trp Single submitter
- p.Arg387Gln Single submitter
- p.Arg416Cys Single submitter
- p.Arg416His Single submitter
- p.Arg421Cys Single submitter
- p.Arg421His Single submitter
- p.Arg453Gln Single submitter
- p.Arg557Cys Single submitter
- p.Arg566Cys Single submitter
- p.Arg566His Single submitter
- p.Arg566Pro Single submitter
- p.Asn370Lys Single submitter
- p.Asp160Gly Single submitter
- p.Asp277Asn Single submitter
- p.Asp337Gly Single submitter
- p.Asp417Asn Single submitter
- p.Cys356Arg Single submitter
- p.Cys439Arg Single submitter
- p.Cys568Ser Single submitter
- p.Gln300Arg Single submitter
- p.Glu173Asp Single submitter
- p.Glu448Gln Single submitter
- p.Gly194Arg Single submitter
- p.Gly351Arg Single submitter
- p.Gly550Ala Single submitter
- p.Gly571Ala Single submitter
- p.Ile124Thr Single submitter
- p.Ile576Val Single submitter
- p.Met363Thr Single submitter
- p.Met462Thr Single submitter
- p.Phe25Leu Single submitter ⚠
- p.Pro210Leu Single submitter
- p.Pro409Ala Single submitter
- p.Pro455Ser Single submitter
- p.Pro621Arg Single submitter
- p.Ser161Asn Single submitter
- p.Ser482Tyr Single submitter
- p.Ser534Arg Single submitter
- p.Thr195Ile Single submitter
- p.Thr424Met Single submitter
- p.Thr544Asn Single submitter
- p.Thr588Ile Single submitter
- p.Val504Met Single submitter
- p.Val519Met Single submitter
- p.Val551Met Single submitter
- p.Val581Ala Single submitter