ARPC5L — 19 ClinVar variants
All ClinVar germline ARPC5L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Likely benign · 17 Uncertain significance
Full ARPC5L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARPC5L p.Arg55Gln Uncertain significance Single submitter
- ARPC5L p.Arg55Gly Uncertain significance Single submitter
- ARPC5L p.Glu29Ala Uncertain significance Single submitter
- ARPC5L p.Gly104Ser Uncertain significance Single submitter
- ARPC5L p.His58Arg Uncertain significance Single submitter
- ARPC5L p.Pro37Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ARPC5L p.Ala35Gly Likely benign Single submitter
- ARPC5L p.Ala59Glu Uncertain significance Single submitter
- ARPC5L p.Ala72Thr Uncertain significance Single submitter
- ARPC5L p.Arg62Trp Uncertain significance Single submitter
- ARPC5L p.Glu94Gln Uncertain significance Single submitter
- ARPC5L p.Leu47Phe Uncertain significance Single submitter
- ARPC5L p.Phe18Leu Uncertain significance Single submitter
- ARPC5L p.Ser64Phe Uncertain significance Single submitter
- ARPC5L p.Ser8Trp Uncertain significance Single submitter
- ARPC5L p.Val126Ala Uncertain significance Single submitter
- ARPC5L p.Val126Leu Uncertain significance Single submitter
- ARPC5L p.Val80Met Uncertain significance Single submitter
All ARPC5L variants
Likely benign 2
- p.Ala35Gly Single submitter ⚠
- p.Val105Ile Single submitter
Uncertain significance 17
- p.Ala59Glu Single submitter ⚠
- p.Ala72Thr Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg55Gly Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Glu29Ala Single submitter ⚠
- p.Glu94Gln Single submitter ⚠
- p.Gly104Ser Single submitter ⚠
- p.His58Arg Single submitter ⚠
- p.Leu47Phe Single submitter ⚠
- p.Phe18Leu Single submitter ⚠
- p.Pro37Ala Single submitter ⚠
- p.Ser64Phe Single submitter ⚠
- p.Ser8Trp Single submitter ⚠
- p.Val126Ala Single submitter ⚠
- p.Val126Leu Single submitter ⚠
- p.Val80Met Single submitter ⚠