ARPIN — 56 ClinVar variants
All ClinVar germline ARPIN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Likely benign · 55 Uncertain significance
Full ARPIN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARPIN p.Ala115Val Uncertain significance Single submitter
- ARPIN p.Ala23Val Uncertain significance Single submitter
- ARPIN p.Ala27Thr Uncertain significance Single submitter
- ARPIN p.Ala87Thr Uncertain significance Single submitter
- ARPIN p.Arg159Gln Uncertain significance Single submitter
- ARPIN p.Arg213Gln Uncertain significance Single submitter
- ARPIN p.Arg55Lys Uncertain significance Single submitter
- ARPIN p.Asn92His Uncertain significance Single submitter
- ARPIN p.Asp107Ala Uncertain significance Single submitter
- ARPIN p.Asp107Gly Uncertain significance Single submitter
- ARPIN p.Asp165Asn Uncertain significance Single submitter
- ARPIN p.Asp170Gly Uncertain significance Single submitter
- ARPIN p.Asp188Gly Uncertain significance Single submitter
- ARPIN p.Asp217Asn Uncertain significance Single submitter
- ARPIN p.Cys183Tyr Uncertain significance Single submitter
- ARPIN p.Gln215Arg Uncertain significance Single submitter
- ARPIN p.Glu114Lys Uncertain significance Single submitter
- ARPIN p.Glu211Asp Uncertain significance Single submitter
- ARPIN p.Glu82Lys Uncertain significance Single submitter
- ARPIN p.Gly34Cys Uncertain significance Single submitter
- ARPIN p.His68Asp Uncertain significance Single submitter
- ARPIN p.Ile42Met Uncertain significance Single submitter
- ARPIN p.Lys182Thr Uncertain significance Single submitter
- ARPIN p.Lys206Asn Uncertain significance Single submitter
- ARPIN p.Lys77Arg Uncertain significance Single submitter
- ARPIN p.Met97Leu Uncertain significance Single submitter
- ARPIN p.Pro26Ser Uncertain significance Single submitter
- ARPIN p.Ser99Pro Uncertain significance Single submitter
- ARPIN p.Thr108Asn Uncertain significance Single submitter
- ARPIN p.Thr112Pro Uncertain significance Single submitter
- ARPIN p.Thr186Ile Uncertain significance Single submitter
- ARPIN p.Thr88Pro Uncertain significance Single submitter
- ARPIN p.Thr93Met Uncertain significance Single submitter
- ARPIN p.Val35Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- ARPIN p.Ala115Pro Uncertain significance Single submitter
- ARPIN p.Ala139Thr Uncertain significance Single submitter
- ARPIN p.Ala139Val Uncertain significance Single submitter
- ARPIN p.Ala76Val Uncertain significance Single submitter
- ARPIN p.Arg159Trp Uncertain significance Single submitter
- ARPIN p.Arg46Trp Uncertain significance Single submitter
- ARPIN p.Arg71Cys Uncertain significance Single submitter
- ARPIN p.Arg71His Uncertain significance Single submitter
- ARPIN p.Asp165Val Uncertain significance Single submitter
- ARPIN p.Glu222Lys Uncertain significance Single submitter
- ARPIN p.Gly187Val Uncertain significance Single submitter
- ARPIN p.Gly207Trp Uncertain significance Single submitter
- ARPIN p.Gly34Ser Uncertain significance Single submitter
- ARPIN p.Leu62Val Uncertain significance Single submitter
- ARPIN p.Met97Ile Uncertain significance Single submitter
- ARPIN p.Phe185Leu Uncertain significance Single submitter
- ARPIN p.Pro123Leu Uncertain significance Single submitter
- ARPIN p.Ser131Ile Uncertain significance Single submitter
- ARPIN p.Ser98Leu Uncertain significance Single submitter
- ARPIN p.Val35Ala Uncertain significance Single submitter
All ARPIN variants
Likely benign 1
- p.Thr52Ala Single submitter
Uncertain significance 55
- c.169-963_177del Single submitter
- p.Ala115Pro Single submitter ⚠
- p.Ala115Val Single submitter ⚠
- p.Ala139Thr Single submitter ⚠
- p.Ala139Val Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Ala87Thr Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg159Trp Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg55Lys Single submitter ⚠
- p.Arg71Cys Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Asn92His Single submitter ⚠
- p.Asp107Ala Single submitter ⚠
- p.Asp107Gly Single submitter ⚠
- p.Asp165Asn Single submitter ⚠
- p.Asp165Val Single submitter ⚠
- p.Asp170Gly Single submitter ⚠
- p.Asp188Gly Single submitter ⚠
- p.Asp217Asn Single submitter ⚠
- p.Cys183Tyr Single submitter ⚠
- p.Gln215Arg Single submitter ⚠
- p.Glu114Lys Single submitter ⚠
- p.Glu211Asp Single submitter ⚠
- p.Glu222Lys Single submitter ⚠
- p.Glu82Lys Single submitter ⚠
- p.Gly187Val Single submitter ⚠
- p.Gly207Trp Single submitter ⚠
- p.Gly34Cys Single submitter ⚠
- p.Gly34Ser Single submitter ⚠
- p.His68Asp Single submitter ⚠
- p.Ile42Met Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Lys182Thr Single submitter ⚠
- p.Lys206Asn Single submitter ⚠
- p.Lys77Arg Single submitter ⚠
- p.Met97Ile Single submitter ⚠
- p.Met97Leu Single submitter ⚠
- p.Phe185Leu Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Pro26Ser Single submitter ⚠
- p.Ser131Ile Single submitter ⚠
- p.Ser98Leu Single submitter ⚠
- p.Ser99Pro Single submitter ⚠
- p.Thr108Asn Single submitter ⚠
- p.Thr112Pro Single submitter ⚠
- p.Thr186Ile Single submitter ⚠
- p.Thr88Pro Single submitter ⚠
- p.Thr93Met Single submitter ⚠
- p.Val35Ala Single submitter ⚠
- p.Val35Ile Single submitter ⚠