ARPP19 — 8 ClinVar variants
All ClinVar germline ARPP19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full ARPP19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARPP19 p.Ala34Ser Uncertain significance Single submitter
- ARPP19 p.Ala3Val Uncertain significance Single submitter
- ARPP19 p.Ala9Thr Uncertain significance Single submitter
- ARPP19 p.Asp47His Uncertain significance Single submitter
- ARPP19 p.Gln14Glu Uncertain significance Single submitter
- ARPP19 p.Glu18Lys Uncertain significance Single submitter
- ARPP19 p.Pro6Leu Uncertain significance Single submitter
- ARPP19 p.Pro95Leu Uncertain significance Single submitter
All ARPP19 variants
Uncertain significance 8
- p.Ala34Ser Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Asp47His Single submitter ⚠
- p.Gln14Glu Single submitter ⚠
- p.Glu18Lys Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Pro95Leu Single submitter ⚠