ARRB2 — 47 ClinVar variants
All ClinVar germline ARRB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Benign · 2 Likely benign · 43 Uncertain significance
Full ARRB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARRB2 p.Ala362Thr Uncertain significance Single submitter
- ARRB2 p.Arg189Cys Uncertain significance Single submitter
- ARRB2 p.Arg196Gln Uncertain significance Single submitter
- ARRB2 p.Arg26Gln Uncertain significance Single submitter
- ARRB2 p.Arg283Trp Uncertain significance Single submitter
- ARRB2 p.Arg52His Uncertain significance Single submitter
- ARRB2 p.Arg63His Uncertain significance Single submitter
- ARRB2 p.Arg96Gln Uncertain significance Single submitter
- ARRB2 p.Asp39Gly Uncertain significance Single submitter
- ARRB2 p.Cys151Tyr Uncertain significance Single submitter
- ARRB2 p.Cys60Ser Uncertain significance Single submitter
- ARRB2 p.Gln102Glu Uncertain significance Single submitter
- ARRB2 p.His114Tyr Uncertain significance Single submitter
- ARRB2 p.Ile374Thr Uncertain significance Single submitter
- ARRB2 p.Leu316Pro Uncertain significance Single submitter
- ARRB2 p.Leu319Pro Uncertain significance Single submitter
- ARRB2 p.Lys230Glu Uncertain significance Single submitter
- ARRB2 p.Pro95Ser Uncertain significance Single submitter
- ARRB2 p.Ser331Phe Uncertain significance Single submitter
- ARRB2 p.Val172Ala Uncertain significance Single submitter
- ARRB2 p.Val367Ile Uncertain significance Single submitter
- ARRB2 p.Val54Ala Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- ARRB2 p.Arg100Cys Uncertain significance Single submitter
- ARRB2 p.Arg148Gln Uncertain significance Single submitter
- ARRB2 p.Asn163Ser Uncertain significance Single submitter
- ARRB2 p.Asn300Ser Uncertain significance Single submitter
- ARRB2 p.Asp33Asn Uncertain significance Single submitter
- ARRB2 p.Asp406Asn Uncertain significance Single submitter
- ARRB2 p.Gln249His Uncertain significance Single submitter
- ARRB2 p.Glu309Gln Uncertain significance Single submitter
- ARRB2 p.His114Asn Uncertain significance Single submitter
- ARRB2 p.His160Arg Uncertain significance Single submitter
- ARRB2 p.His346Gln Uncertain significance Single submitter
- ARRB2 p.Leu355Phe Uncertain significance Single submitter
- ARRB2 p.Leu49Val Uncertain significance Single submitter
- ARRB2 p.Lys206Arg Uncertain significance Single submitter
- ARRB2 p.Lys293Gln Uncertain significance Single submitter
- ARRB2 p.Phe269Leu Uncertain significance Single submitter
- ARRB2 p.Pro15Ser Uncertain significance Single submitter
- ARRB2 p.Pro354Leu Uncertain significance Single submitter
- ARRB2 p.Pro90Leu Uncertain significance Single submitter
- ARRB2 p.Ser13Leu Uncertain significance Single submitter
- ARRB2 p.Thr382Ile Uncertain significance Single submitter
All ARRB2 variants
Likely benign 2
- p.Asn216Ser Single submitter
- p.Ile306= Single submitter
Uncertain significance 43
- p.Ala362Thr Single submitter ⚠
- p.Arg100Cys Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg189Cys Single submitter ⚠
- p.Arg196Gln Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg283Trp Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Asn163Ser Single submitter ⚠
- p.Asn300Ser Single submitter ⚠
- p.Asp33Asn Single submitter ⚠
- p.Asp39Gly Single submitter ⚠
- p.Asp406Asn Single submitter ⚠
- p.Cys151Tyr Single submitter ⚠
- p.Cys60Ser Single submitter ⚠
- p.Gln102Glu Single submitter ⚠
- p.Gln249His Single submitter ⚠
- p.Glu309Gln Single submitter ⚠
- p.His114Asn Single submitter ⚠
- p.His114Tyr Single submitter ⚠
- p.His160Arg Single submitter ⚠
- p.His346Gln Single submitter ⚠
- p.Ile374Thr Single submitter ⚠
- p.Leu316Pro Single submitter ⚠
- p.Leu319Pro Single submitter ⚠
- p.Leu355Phe Single submitter ⚠
- p.Leu49Val Single submitter ⚠
- p.Lys206Arg Single submitter ⚠
- p.Lys230Glu Single submitter ⚠
- p.Lys293Gln Single submitter ⚠
- p.Phe269Leu Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro354Leu Single submitter ⚠
- p.Pro90Leu Single submitter ⚠
- p.Pro95Ser Single submitter ⚠
- p.Ser13Leu Single submitter ⚠
- p.Ser331Phe Single submitter ⚠
- p.Thr382Ile Single submitter ⚠
- p.Val172Ala Single submitter ⚠
- p.Val367Ile Single submitter ⚠
- p.Val54Ala Single submitter ⚠