ARRDC2 — 71 ClinVar variants
All ClinVar germline ARRDC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Likely benign · 70 Uncertain significance
Full ARRDC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARRDC2 p.Ala232Thr Uncertain significance Single submitter
- ARRDC2 p.Ala232Val Uncertain significance Single submitter
- ARRDC2 p.Ala353Thr Uncertain significance Single submitter
- ARRDC2 p.Ala375Ser Uncertain significance Single submitter
- ARRDC2 p.Ala375Thr Uncertain significance Single submitter
- ARRDC2 p.Arg128Ser Uncertain significance Single submitter
- ARRDC2 p.Arg181His Uncertain significance Single submitter
- ARRDC2 p.Arg192Cys Uncertain significance Single submitter
- ARRDC2 p.Arg192Gly Uncertain significance Single submitter
- ARRDC2 p.Arg381His Uncertain significance Single submitter
- ARRDC2 p.Arg383Cys Uncertain significance Single submitter
- ARRDC2 p.Arg403His Uncertain significance Single submitter
- ARRDC2 p.Asp156Gly Uncertain significance Single submitter
- ARRDC2 p.Cys404Ser Uncertain significance Single submitter
- ARRDC2 p.Gln235Glu Uncertain significance Single submitter
- ARRDC2 p.Gly26Ser Uncertain significance Single submitter
- ARRDC2 p.Ile263Val Uncertain significance Single submitter
- ARRDC2 p.Lys147Arg Uncertain significance Single submitter
- ARRDC2 p.Lys234Arg Uncertain significance Single submitter
- ARRDC2 p.Met228Thr Uncertain significance Single submitter
- ARRDC2 p.Phe227Leu Uncertain significance Single submitter
- ARRDC2 p.Pro141Thr Uncertain significance Single submitter
- ARRDC2 p.Pro264His Uncertain significance Single submitter
- ARRDC2 p.Pro333Leu Uncertain significance Single submitter
- ARRDC2 p.Pro365Ala Uncertain significance Single submitter
- ARRDC2 p.Pro402Leu Uncertain significance Single submitter
- ARRDC2 p.Ser25Gly Uncertain significance Single submitter
- ARRDC2 p.Ser357Ile Uncertain significance Single submitter
- ARRDC2 p.Thr304Ile Uncertain significance Single submitter
- ARRDC2 p.Val275Ile Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- ARRDC2 p.Ala145Ser Uncertain significance Single submitter
- ARRDC2 p.Ala260Thr Uncertain significance Single submitter
- ARRDC2 p.Ala347Val Uncertain significance Single submitter
- ARRDC2 p.Ala65Gly Uncertain significance Single submitter
- ARRDC2 p.Arg144Gln Uncertain significance Single submitter
- ARRDC2 p.Arg175Gln Uncertain significance Single submitter
- ARRDC2 p.Arg218Gln Uncertain significance Single submitter
- ARRDC2 p.Arg218Trp Uncertain significance Single submitter
- ARRDC2 p.Arg259Trp Uncertain significance Single submitter
- ARRDC2 p.Arg262Gln Uncertain significance Single submitter
- ARRDC2 p.Arg262Trp Uncertain significance Single submitter
- ARRDC2 p.Arg313His Uncertain significance Single submitter
- ARRDC2 p.Arg33Gln Uncertain significance Single submitter
- ARRDC2 p.Arg381Cys Uncertain significance Single submitter
- ARRDC2 p.Arg50Gly Uncertain significance Single submitter
- ARRDC2 p.Asp191Asn Uncertain significance Single submitter
- ARRDC2 p.Asp364Asn Uncertain significance Single submitter
- ARRDC2 p.Glu206Gly Uncertain significance Single submitter
- ARRDC2 p.Glu206Lys Uncertain significance Single submitter
- ARRDC2 p.Gly66Ser Uncertain significance Single submitter
- ARRDC2 p.Leu271Val Uncertain significance Single submitter
- ARRDC2 p.Phe9Leu Uncertain significance Single submitter
- ARRDC2 p.Pro100Leu Uncertain significance Single submitter
- ARRDC2 p.Pro22Ser Uncertain significance Single submitter
- ARRDC2 p.Pro333Thr Uncertain significance Single submitter
- ARRDC2 p.Pro384Leu Uncertain significance Single submitter
- ARRDC2 p.Pro385Leu Uncertain significance Single submitter
- ARRDC2 p.Pro386Leu Uncertain significance Single submitter
- ARRDC2 p.Ser126Arg Uncertain significance Single submitter
- ARRDC2 p.Ser187Leu Uncertain significance Single submitter
- ARRDC2 p.Ser343Leu Uncertain significance Single submitter
- ARRDC2 p.Thr159Met Uncertain significance Single submitter
- ARRDC2 p.Thr226Met Uncertain significance Single submitter
- ARRDC2 p.Thr349Ile Uncertain significance Single submitter
- ARRDC2 p.Tyr75Cys Uncertain significance Single submitter
- ARRDC2 p.Val23Leu Uncertain significance Single submitter
- ARRDC2 p.Val248Leu Uncertain significance Single submitter
- ARRDC2 p.Val266Met Uncertain significance Single submitter
All ARRDC2 variants
Likely benign 1
- p.Gly398Glu Single submitter
Uncertain significance 70
- p.Ala10Pro Single submitter
- p.Ala145Ser Single submitter ⚠
- p.Ala232Thr Single submitter ⚠
- p.Ala232Val Single submitter ⚠
- p.Ala260Thr Single submitter ⚠
- p.Ala347Val Single submitter ⚠
- p.Ala353Thr Single submitter ⚠
- p.Ala375Ser Single submitter ⚠
- p.Ala375Thr Single submitter ⚠
- p.Ala65Gly Single submitter ⚠
- p.Arg128Ser Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg181His Single submitter ⚠
- p.Arg192Cys Single submitter ⚠
- p.Arg192Gly Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg218Trp Single submitter ⚠
- p.Arg259Trp Single submitter ⚠
- p.Arg262Gln Single submitter ⚠
- p.Arg262Trp Single submitter ⚠
- p.Arg2His Single submitter
- p.Arg313His Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg381Cys Single submitter ⚠
- p.Arg381His Single submitter ⚠
- p.Arg383Cys Single submitter ⚠
- p.Arg403His Single submitter ⚠
- p.Arg50Gly Single submitter ⚠
- p.Asp156Gly Single submitter ⚠
- p.Asp191Asn Single submitter ⚠
- p.Asp364Asn Single submitter ⚠
- p.Cys404Ser Single submitter ⚠
- p.Gln235Glu Single submitter ⚠
- p.Glu206Gly Single submitter ⚠
- p.Glu206Lys Single submitter ⚠
- p.Gly26Ser Single submitter ⚠
- p.Gly66Ser Single submitter ⚠
- p.Ile263Val Single submitter ⚠
- p.Leu271Val Single submitter ⚠
- p.Lys147Arg Single submitter ⚠
- p.Lys234Arg Single submitter ⚠
- p.Met228Thr Single submitter ⚠
- p.Phe227Leu Single submitter ⚠
- p.Phe9Leu Single submitter ⚠
- p.Pro100Leu Single submitter ⚠
- p.Pro141Thr Single submitter ⚠
- p.Pro22Ser Single submitter ⚠
- p.Pro264His Single submitter ⚠
- p.Pro333Leu Single submitter ⚠
- p.Pro333Thr Single submitter ⚠
- p.Pro365Ala Single submitter ⚠
- p.Pro384Leu Single submitter ⚠
- p.Pro385Leu Single submitter ⚠
- p.Pro386Leu Single submitter ⚠
- p.Pro402Leu Single submitter ⚠
- p.Ser126Arg Single submitter ⚠
- p.Ser187Leu Single submitter ⚠
- p.Ser25Gly Single submitter ⚠
- p.Ser343Leu Single submitter ⚠
- p.Ser357Ile Single submitter ⚠
- p.Thr159Met Single submitter ⚠
- p.Thr226Met Single submitter ⚠
- p.Thr304Ile Single submitter ⚠
- p.Thr349Ile Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val23Leu Single submitter ⚠
- p.Val248Leu Single submitter ⚠
- p.Val266Met Single submitter ⚠
- p.Val275Ile Single submitter ⚠