ARRDC3 — 45 ClinVar variants
All ClinVar germline ARRDC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Benign · 1 Likely benign · 43 Uncertain significance
Full ARRDC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARRDC3 p.Ala65Thr Uncertain significance Single submitter
- ARRDC3 p.Arg135His Uncertain significance Single submitter
- ARRDC3 p.Arg414Cys Uncertain significance Single submitter
- ARRDC3 p.Arg414His Uncertain significance Single submitter
- ARRDC3 p.Arg93Ile Uncertain significance Single submitter
- ARRDC3 p.Asn361Ser Uncertain significance Single submitter
- ARRDC3 p.Asp279His Uncertain significance Single submitter
- ARRDC3 p.Asp369Glu Uncertain significance Single submitter
- ARRDC3 p.Glu77Ala Uncertain significance Single submitter
- ARRDC3 p.His103Tyr Uncertain significance Single submitter
- ARRDC3 p.Ile164Thr Uncertain significance Single submitter
- ARRDC3 p.Ile309Phe Uncertain significance Single submitter
- ARRDC3 p.Ile383Val Uncertain significance Single submitter
- ARRDC3 p.Ile397Val Uncertain significance Single submitter
- ARRDC3 p.Pro346Leu Uncertain significance Single submitter
- ARRDC3 p.Pro392Ser Uncertain significance Single submitter
- ARRDC3 p.Pro399Ser Uncertain significance Single submitter
- ARRDC3 p.Pro401Ala Uncertain significance Single submitter
- ARRDC3 p.Thr104Ile Uncertain significance Single submitter
- ARRDC3 p.Thr203Asn Uncertain significance Single submitter
- ARRDC3 p.Tyr24His Uncertain significance Single submitter
- ARRDC3 p.Val150Leu Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- ARRDC3 p.Ala227Thr Uncertain significance Single submitter
- ARRDC3 p.Arg109Gly Uncertain significance Single submitter
- ARRDC3 p.Arg284His Uncertain significance Single submitter
- ARRDC3 p.Arg43Ser Uncertain significance Single submitter
- ARRDC3 p.Asn360Lys Uncertain significance Single submitter
- ARRDC3 p.Asp294Ala Uncertain significance Single submitter
- ARRDC3 p.Asp407Tyr Uncertain significance Single submitter
- ARRDC3 p.Ile208Val Uncertain significance Single submitter
- ARRDC3 p.Leu246Phe Uncertain significance Single submitter
- ARRDC3 p.Leu246Pro Uncertain significance Single submitter
- ARRDC3 p.Phe13Leu Uncertain significance Single submitter
- ARRDC3 p.Pro145Ser Uncertain significance Single submitter
- ARRDC3 p.Ser133Asn Uncertain significance Single submitter
- ARRDC3 p.Ser194Gly Uncertain significance Single submitter
- ARRDC3 p.Ser218Cys Uncertain significance Single submitter
- ARRDC3 p.Ser257Pro Uncertain significance Single submitter
- ARRDC3 p.Thr187Ile Uncertain significance Single submitter
- ARRDC3 p.Thr260Ile Uncertain significance Single submitter
- ARRDC3 p.Val23Leu Uncertain significance Single submitter
- ARRDC3 p.Val57Ile Uncertain significance Single submitter
- ARRDC3 p.Glu341Gly Uncertain significance No assertion criteria
All ARRDC3 variants
Benign 1
- p.Lys151= Single submitter
Likely benign 1
- p.Asp279= Single submitter
Uncertain significance 43
- p.Ala227Thr Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg109Gly Single submitter ⚠
- p.Arg135His Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg414Cys Single submitter ⚠
- p.Arg414His Single submitter ⚠
- p.Arg43Ser Single submitter ⚠
- p.Arg93Ile Single submitter ⚠
- p.Asn360Lys Single submitter ⚠
- p.Asn361Ser Single submitter ⚠
- p.Asp279His Single submitter ⚠
- p.Asp294Ala Single submitter ⚠
- p.Asp369Glu Single submitter ⚠
- p.Asp407Tyr Single submitter ⚠
- p.Glu77Ala Single submitter ⚠
- p.His103Tyr Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Ile208Val Single submitter ⚠
- p.Ile309Phe Single submitter ⚠
- p.Ile383Val Single submitter ⚠
- p.Ile397Val Single submitter ⚠
- p.Leu246Phe Single submitter ⚠
- p.Leu246Pro Single submitter ⚠
- p.Phe13Leu Single submitter ⚠
- p.Pro145Ser Single submitter ⚠
- p.Pro346Leu Single submitter ⚠
- p.Pro392Ser Single submitter ⚠
- p.Pro399Ser Single submitter ⚠
- p.Pro401Ala Single submitter ⚠
- p.Ser133Asn Single submitter ⚠
- p.Ser194Gly Single submitter ⚠
- p.Ser218Cys Single submitter ⚠
- p.Ser257Pro Single submitter ⚠
- p.Thr104Ile Single submitter ⚠
- p.Thr187Ile Single submitter ⚠
- p.Thr203Asn Single submitter ⚠
- p.Thr260Ile Single submitter ⚠
- p.Tyr24His Single submitter ⚠
- p.Val150Leu Single submitter ⚠
- p.Val23Leu Single submitter ⚠
- p.Val57Ile Single submitter ⚠
- p.Glu341Gly No assertion criteria ⚠