ARRDC5 — 60 ClinVar variants
All ClinVar germline ARRDC5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
3 Likely benign · 57 Uncertain significance
Full ARRDC5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARRDC5 c.-15A>T Uncertain significance Single submitter
- ARRDC5 c.-24T>C Uncertain significance Single submitter
- ARRDC5 p.Ala241Val Uncertain significance Single submitter
- ARRDC5 p.Ala305Asp Uncertain significance Single submitter
- ARRDC5 p.Ala305Thr Uncertain significance Single submitter
- ARRDC5 p.Ala90Ser Uncertain significance Single submitter
- ARRDC5 p.Arg247His Uncertain significance Single submitter
- ARRDC5 p.Asn249Thr Uncertain significance Single submitter
- ARRDC5 p.Asp325Asn Uncertain significance Single submitter
- ARRDC5 p.Asp37Glu Uncertain significance Single submitter
- ARRDC5 p.Asp61Asn Uncertain significance Single submitter
- ARRDC5 p.Asp85Gly Uncertain significance Single submitter
- ARRDC5 p.Cys168Phe Uncertain significance Single submitter
- ARRDC5 p.Gln177Arg Uncertain significance Single submitter
- ARRDC5 p.Gln217Lys Uncertain significance Single submitter
- ARRDC5 p.Glu219Lys Uncertain significance Single submitter
- ARRDC5 p.Glu51Lys Uncertain significance Single submitter
- ARRDC5 p.Glu84Lys Uncertain significance Single submitter
- ARRDC5 p.Gly114Asp Uncertain significance Single submitter
- ARRDC5 p.Gly126Cys Uncertain significance Single submitter
- ARRDC5 p.Gly91Asp Uncertain significance Single submitter
- ARRDC5 p.His129Gln Uncertain significance Single submitter
- ARRDC5 p.Leu11Met Uncertain significance Single submitter
- ARRDC5 p.Lys206Arg Uncertain significance Single submitter
- ARRDC5 p.Pro223Leu Uncertain significance Single submitter
- ARRDC5 p.Ser264Ala Uncertain significance Single submitter
- ARRDC5 p.Ser304Gly Uncertain significance Single submitter
- ARRDC5 p.Thr110Ile Uncertain significance Single submitter
- ARRDC5 p.Val120Ile Uncertain significance Single submitter
- ARRDC5 p.Val245Leu Uncertain significance Single submitter
- ARRDC5 p.Val40Gly Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- ARRDC5 p.Arg135Gly Uncertain significance Single submitter
- ARRDC5 p.Arg227Trp Uncertain significance Single submitter
- ARRDC5 p.Glu43Lys Uncertain significance Single submitter
- ARRDC5 p.Glu8Gly Uncertain significance Single submitter
- ARRDC5 p.Gly220Asp Uncertain significance Single submitter
- ARRDC5 p.His93Pro Uncertain significance Single submitter
- ARRDC5 p.Ile197Met Uncertain significance Single submitter
- ARRDC5 p.Ile216Met Uncertain significance Single submitter
- ARRDC5 p.Ile274Met Uncertain significance Single submitter
- ARRDC5 p.Leu259Met Uncertain significance Single submitter
- ARRDC5 p.Lys252Glu Uncertain significance Single submitter
- ARRDC5 p.Met180Ile Uncertain significance Single submitter
- ARRDC5 p.Pro12Ala Uncertain significance Single submitter
- ARRDC5 p.Pro288Ala Uncertain significance Single submitter
- ARRDC5 p.Thr194Ile Uncertain significance Single submitter
- ARRDC5 p.Thr195Arg Uncertain significance Single submitter
- ARRDC5 p.Thr201Ile Uncertain significance Single submitter
- ARRDC5 p.Thr207Met Uncertain significance Single submitter
- ARRDC5 p.Thr222Met Uncertain significance Single submitter
- ARRDC5 p.Thr277Ala Uncertain significance Single submitter
- ARRDC5 p.Thr277Asn Uncertain significance Single submitter
- ARRDC5 p.Thr303Ile Uncertain significance Single submitter
- ARRDC5 p.Tyr74His Uncertain significance Single submitter
- ARRDC5 p.Val158Met Uncertain significance Single submitter
- ARRDC5 p.Val285Met Uncertain significance Single submitter
- ARRDC5 p.Val322Met Uncertain significance Single submitter
All ARRDC5 variants
Likely benign 3
- p.Glu13Lys Single submitter
- p.Val245Met Single submitter
- p.Val50= Single submitter
Uncertain significance 57
- c.-15A>T Single submitter ⚠
- c.-24T>C Single submitter ⚠
- p.Ala241Val Single submitter ⚠
- p.Ala305Asp Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala90Ser Single submitter ⚠
- p.Arg135Gly Single submitter ⚠
- p.Arg227Trp Single submitter ⚠
- p.Arg247His Single submitter ⚠
- p.Asn249Thr Single submitter ⚠
- p.Asp325Asn Single submitter ⚠
- p.Asp37Glu Single submitter ⚠
- p.Asp61Asn Single submitter ⚠
- p.Asp85Gly Single submitter ⚠
- p.Cys168Phe Single submitter ⚠
- p.Gln177Arg Single submitter ⚠
- p.Gln217Lys Single submitter ⚠
- p.Glu219Lys Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Glu84Lys Single submitter ⚠
- p.Glu8Gly Single submitter ⚠
- p.Gly114Asp Single submitter ⚠
- p.Gly126Cys Single submitter ⚠
- p.Gly220Asp Single submitter ⚠
- p.Gly91Asp Single submitter ⚠
- p.His129Gln Single submitter ⚠
- p.His93Pro Single submitter ⚠
- p.Ile197Met Single submitter ⚠
- p.Ile216Met Single submitter ⚠
- p.Ile274Met Single submitter ⚠
- p.Leu11Met Single submitter ⚠
- p.Leu259Met Single submitter ⚠
- p.Lys206Arg Single submitter ⚠
- p.Lys252Glu Single submitter ⚠
- p.Met180Ile Single submitter ⚠
- p.Pro12Ala Single submitter ⚠
- p.Pro223Leu Single submitter ⚠
- p.Pro288Ala Single submitter ⚠
- p.Ser264Ala Single submitter ⚠
- p.Ser304Gly Single submitter ⚠
- p.Thr110Ile Single submitter ⚠
- p.Thr194Ile Single submitter ⚠
- p.Thr195Arg Single submitter ⚠
- p.Thr201Ile Single submitter ⚠
- p.Thr207Met Single submitter ⚠
- p.Thr222Met Single submitter ⚠
- p.Thr277Ala Single submitter ⚠
- p.Thr277Asn Single submitter ⚠
- p.Thr303Ile Single submitter ⚠
- p.Tyr74His Single submitter ⚠
- p.Val120Ile Single submitter ⚠
- p.Val158Met Single submitter ⚠
- p.Val245Leu Single submitter ⚠
- p.Val285Met Single submitter ⚠
- p.Val322Met Single submitter ⚠
- p.Val40Gly Single submitter ⚠