ART1 — 77 ClinVar variants
All ClinVar germline ART1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Benign · 2 Likely benign · 73 Uncertain significance
Full ART1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ART1 p.Ala120Pro Uncertain significance Single submitter
- ART1 p.Ala227Thr Uncertain significance Single submitter
- ART1 p.Ala254Thr Uncertain significance Single submitter
- ART1 p.Ala262Thr Uncertain significance Single submitter
- ART1 p.Ala51Pro Uncertain significance Single submitter
- ART1 p.Ala55Gly Uncertain significance Single submitter
- ART1 p.Ala56Thr Uncertain significance Single submitter
- ART1 p.Arg263His Uncertain significance Single submitter
- ART1 p.Arg92Ser Uncertain significance Single submitter
- ART1 p.Asp282Glu Uncertain significance Single submitter
- ART1 p.Asp293Asn Uncertain significance Single submitter
- ART1 p.Asp31His Uncertain significance Single submitter
- ART1 p.Asp48Asn Uncertain significance Single submitter
- ART1 p.Cys224Trp Uncertain significance Single submitter
- ART1 p.Cys53Tyr Uncertain significance Single submitter
- ART1 p.Gln250Arg Uncertain significance Single submitter
- ART1 p.Glu160Lys Uncertain significance Single submitter
- ART1 p.Glu240Lys Uncertain significance Single submitter
- ART1 p.Gly166Arg Uncertain significance Single submitter
- ART1 p.Gly199Ser Uncertain significance Single submitter
- ART1 p.Gly220Val Uncertain significance Single submitter
- ART1 p.Ile27Thr Uncertain significance Single submitter
- ART1 p.Ile280Val Uncertain significance Single submitter
- ART1 p.Leu184Val Uncertain significance Single submitter
- ART1 p.Lys206Asn Uncertain significance Single submitter
- ART1 p.Lys283Asn Uncertain significance Single submitter
- ART1 p.Met6Val Uncertain significance Single submitter
- ART1 p.Phe219Val Uncertain significance Single submitter
- ART1 p.Pro244Thr Uncertain significance Single submitter
- ART1 p.Pro245Ser Uncertain significance Single submitter
- ART1 p.Pro324Leu Uncertain significance Single submitter
- ART1 p.Ser204Phe Uncertain significance Single submitter
- ART1 p.Ser300Arg Uncertain significance Single submitter
- ART1 p.Trp313Cys Uncertain significance Single submitter
- ART1 p.Trp86Arg Uncertain significance Single submitter
- ART1 p.Val305Ile Uncertain significance Single submitter
- ART1 p.Val316Met Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- ART1 p.Ala133Val Uncertain significance Single submitter
- ART1 p.Ala138Val Uncertain significance Single submitter
- ART1 p.Ala161Ser Uncertain significance Single submitter
- ART1 p.Ala227Gly Uncertain significance Single submitter
- ART1 p.Ala227Ser Uncertain significance Single submitter
- ART1 p.Arg102Cys Uncertain significance Single submitter
- ART1 p.Arg136Cys Uncertain significance Single submitter
- ART1 p.Arg140Cys Uncertain significance Single submitter
- ART1 p.Arg142Gln Uncertain significance Single submitter
- ART1 p.Arg142Trp Uncertain significance Single submitter
- ART1 p.Arg170Cys Uncertain significance Single submitter
- ART1 p.Arg170Pro Uncertain significance Single submitter
- ART1 p.Arg263Cys Uncertain significance Single submitter
- ART1 p.Arg29Gln Uncertain significance Single submitter
- ART1 p.Arg29Gly Uncertain significance Single submitter
- ART1 p.Arg89His Uncertain significance Single submitter
- ART1 p.Glu113Lys Uncertain significance Single submitter
- ART1 p.Gly166Asp Uncertain significance Single submitter
- ART1 p.Gly231Cys Uncertain significance Single submitter
- ART1 p.His144Arg Uncertain significance Single submitter
- ART1 p.Leu10Ile Uncertain significance Single submitter
- ART1 p.Leu205Val Uncertain significance Single submitter
- ART1 p.Leu302His Uncertain significance Single submitter
- ART1 p.Leu312Phe Uncertain significance Single submitter
- ART1 p.Pro191Ser Uncertain significance Single submitter
- ART1 p.Pro228Ser Uncertain significance Single submitter
- ART1 p.Pro245Ala Uncertain significance Single submitter
- ART1 p.Pro62Leu Uncertain significance Single submitter
- ART1 p.Ser125Arg Uncertain significance Single submitter
- ART1 p.Ser125Gly Uncertain significance Single submitter
- ART1 p.Ser150Phe Uncertain significance Single submitter
- ART1 p.Thr101Ile Uncertain significance Single submitter
- ART1 p.Thr217Ala Uncertain significance Single submitter
- ART1 p.Thr67Arg Uncertain significance Single submitter
- ART1 p.Thr67Met Uncertain significance Single submitter
- ART1 p.Tyr75Cys Uncertain significance Single submitter
All ART1 variants
Likely benign 2
- p.Arg173Gln Single submitter
- p.Arg185His Single submitter
Uncertain significance 73
- p.Ala120Pro Single submitter ⚠
- p.Ala133Val Single submitter ⚠
- p.Ala138Val Single submitter ⚠
- p.Ala161Ser Single submitter ⚠
- p.Ala227Gly Single submitter ⚠
- p.Ala227Ser Single submitter ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala254Thr Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala51Pro Single submitter ⚠
- p.Ala55Gly Single submitter ⚠
- p.Ala56Thr Single submitter ⚠
- p.Arg102Cys Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg140Cys Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg170Pro Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg263His Single submitter ⚠
- p.Arg29Gln Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg89His Single submitter ⚠
- p.Arg92Ser Single submitter ⚠
- p.Asp282Glu Single submitter ⚠
- p.Asp293Asn Single submitter ⚠
- p.Asp31His Single submitter ⚠
- p.Asp48Asn Single submitter ⚠
- p.Cys224Trp Single submitter ⚠
- p.Cys53Tyr Single submitter ⚠
- p.Gln250Arg Single submitter ⚠
- p.Glu113Lys Single submitter ⚠
- p.Glu160Lys Single submitter ⚠
- p.Glu240Lys Single submitter ⚠
- p.Gly166Arg Single submitter ⚠
- p.Gly166Asp Single submitter ⚠
- p.Gly199Ser Single submitter ⚠
- p.Gly220Val Single submitter ⚠
- p.Gly231Cys Single submitter ⚠
- p.His144Arg Single submitter ⚠
- p.Ile27Thr Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Leu10Ile Single submitter ⚠
- p.Leu184Val Single submitter ⚠
- p.Leu205Val Single submitter ⚠
- p.Leu302His Single submitter ⚠
- p.Leu312Phe Single submitter ⚠
- p.Lys206Asn Single submitter ⚠
- p.Lys283Asn Single submitter ⚠
- p.Met6Val Single submitter ⚠
- p.Phe219Val Single submitter ⚠
- p.Pro191Ser Single submitter ⚠
- p.Pro228Ser Single submitter ⚠
- p.Pro244Thr Single submitter ⚠
- p.Pro245Ala Single submitter ⚠
- p.Pro245Ser Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Pro62Leu Single submitter ⚠
- p.Ser125Arg Single submitter ⚠
- p.Ser125Gly Single submitter ⚠
- p.Ser150Phe Single submitter ⚠
- p.Ser204Phe Single submitter ⚠
- p.Ser300Arg Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr217Ala Single submitter ⚠
- p.Thr67Arg Single submitter ⚠
- p.Thr67Met Single submitter ⚠
- p.Trp313Cys Single submitter ⚠
- p.Trp86Arg Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val305Ile Single submitter ⚠
- p.Val316Met Single submitter ⚠