ART4 — 37 ClinVar variants
All ClinVar germline ART4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
3 Benign · 1 Likely benign · 33 Uncertain significance
Full ART4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ART4 p.Ala103Val Uncertain significance Single submitter
- ART4 p.Ala20Ser Uncertain significance Single submitter
- ART4 p.Ala50Thr Uncertain significance Single submitter
- ART4 p.Arg171Lys Uncertain significance Single submitter
- ART4 p.Arg263Gly Uncertain significance Single submitter
- ART4 p.Asn257Ser Uncertain significance Single submitter
- ART4 p.Asp293His Uncertain significance Single submitter
- ART4 p.Asp56Asn Uncertain significance Single submitter
- ART4 p.His160Arg Uncertain significance Single submitter
- ART4 p.Ile228Lys Uncertain significance Single submitter
- ART4 p.Ile291Leu Uncertain significance Single submitter
- ART4 p.Ile307Val Uncertain significance Single submitter
- ART4 p.Ile87Val Uncertain significance Single submitter
- ART4 p.Leu225Val Uncertain significance Single submitter
- ART4 p.Lys288Asn Uncertain significance Single submitter
- ART4 p.Met96Ile Uncertain significance Single submitter
- ART4 p.Thr118Ala Uncertain significance Single submitter
- ART4 p.Thr84Ile Uncertain significance Single submitter
- ART4 p.Trp25Arg Uncertain significance Single submitter
- ART4 p.Val236Ile Uncertain significance Single submitter
- ART4 p.Val49Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ART4 p.Ala58Thr Uncertain significance Single submitter
- ART4 p.Arg171Thr Uncertain significance Single submitter
- ART4 p.Asp54Asn Uncertain significance Single submitter
- ART4 p.Gln65Arg Uncertain significance Single submitter
- ART4 p.Ile247Phe Uncertain significance Single submitter
- ART4 p.Leu34Pro Uncertain significance Single submitter
- ART4 p.Phe55Leu Uncertain significance Single submitter
- ART4 p.Phe55Ser Uncertain significance Single submitter
- ART4 p.Phe83Ser Uncertain significance Single submitter
- ART4 p.Ser305Asn Uncertain significance Single submitter
- ART4 p.Thr210Ala Uncertain significance Single submitter
- ART4 p.Tyr126Cys Uncertain significance Single submitter
All ART4 variants
Benign 3
- p.Leu208= No assertion criteria ART4-related disorder
- p.Leu300Val No assertion criteria ART4-related disorder
- p.Tyr126= No assertion criteria ART4-related disorder
Likely benign 1
- p.Thr272Ala Single submitter
Uncertain significance 33
- p.Ala103Val Single submitter ⚠
- p.Ala20Ser Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Ala58Thr Single submitter ⚠
- p.Arg171Lys Single submitter ⚠
- p.Arg171Thr Single submitter ⚠
- p.Arg263Gly Single submitter ⚠
- p.Asn257Ser Single submitter ⚠
- p.Asp293His Single submitter ⚠
- p.Asp54Asn Single submitter ⚠
- p.Asp56Asn Single submitter ⚠
- p.Gln65Arg Single submitter ⚠
- p.His160Arg Single submitter ⚠
- p.Ile228Lys Single submitter ⚠
- p.Ile247Phe Single submitter ⚠
- p.Ile291Leu Single submitter ⚠
- p.Ile307Val Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu225Val Single submitter ⚠
- p.Leu34Pro Single submitter ⚠
- p.Lys288Asn Single submitter ⚠
- p.Met96Ile Single submitter ⚠
- p.Phe55Leu Single submitter ⚠
- p.Phe55Ser Single submitter ⚠
- p.Phe83Ser Single submitter ⚠
- p.Ser305Asn Single submitter ⚠
- p.Thr118Ala Single submitter ⚠
- p.Thr210Ala Single submitter ⚠
- p.Thr84Ile Single submitter ⚠
- p.Trp25Arg Single submitter ⚠
- p.Tyr126Cys Single submitter ⚠
- p.Val236Ile Single submitter ⚠
- p.Val49Ile Single submitter ⚠